Search results | J. Murrey Atkins Library

Title: Analysis and Development of Targeting Strategies for Bacterial Sugars
Author: Erickson, Katelyn
Date Created: 2018
Subjects--Topical: Chemistry, Biochemistry
Description: Bacterial cell surface exopolysaccharides aid in protecting microbes from the defense mechanisms of the host, and differ substantially in structure between species. Exploiting these structural differences would be advantageous to target certain ty...

Title: Bacterial Glycan Immobilization for Interacting Partner Analysis
Author: Murray, Alexis
Date Created: 2023
Subjects--Topical: Chemistry
Description: Bacterial cell surface glycans mediate pathogenic and symbiotic interactions with hosts and other organisms. The implications of bacterial glycans in human health have made them attractive targets in drug design for antibiotics, antibacterial vacc...

Title: CHARACTERIZATION OF THE BIOSYNTHETIC PATHWAY OF CAPSULAR POLYSACCHARIDE A IN BACTEROIDES FRAGILIS
Author: Sharma, Sunita
Date Created: 2019
Subjects--Topical: Molecular biology, Biology
Description: Capsular Polysaccharide A (CPSA) is a polymer of a tetrasaccharide unit found on the surface of the symbiotic gut bacteria Bacteroides fragilis. It has been suggested that CPSA is vital for maintaining a normal balance between the levels of Th1 an...

Title: Characterization of the Colanic Acid Biosynthesis Pathway with a Fluorescent Bactoprenyl Monophosphate Analogue
Author: Scott, Phillip
Date Created: 2015
Subjects--Topical: Biochemistry
Description: When introduced to harsh conditions such as low pH, pathogenic Escherichia coli can secrete colanic acid, an exopolysaccharide that completely engulfs the organism, to establish a protective barrier between the organism and the acidic environment....

Title: Chemoenzymatic Preparation of Probes for in vitro and Cellular Elucidation of Complex Bacteria Polysaccharides
Author: Reid, Amanda
Date Created: 2021
Subjects--Topical: Microbiology, Biochemistry, Analytical chemistry
Description: Bacteria play a major role in our health and wellbeing. The microbe-host interaction is often mediated by sugar polymers at the cell surface. An incredibly diverse amount of glycan variation exists throughout these structures, which makes identifi...

Title: Complex Glycan Synthesis in Bacteria
Author: Wallen, Timothy
Date Created: 2019
Subjects--Topical: Chemistry
Description: Glycans, which are assembled through a process known as glycosylation, are critical for creating biological structures important for the function and vitality of bacterial cells. In order to study the synthesis of glycans, enzymes and intermediate...

Title: ELUCIDATING THE MOLECULAR BASIS OF INHIBITION OF ENZYMES ESSENTIAL FOR BATERIALVIRULENCE: THE ACTIVITY OF THREE GLYCOSYLTRANSFERASES AND A POTENTIAL DRUG TARGET, UNDECAPRENYL PYROPHOSPHATE SYNTHASE
Author: Okwei, Elleansar
Date Created: 2016
Subjects--Topical: Chemistry, Biology, Biochemistry
Description: The fight against bacterial infection is one of the most important branches of modern medicine. Due to the emergence of strains of antibiotic-resistant bacteria, researchers have been presented with complex challenges in an effort to combat these ...

Title: Early Detection of Malaria Parasitic RNA Through an Amplification-Free Surface-Enhanced Raman Spectroscopy Biosensor
Author: Blackwell, Ashley
Date Created: 2022
Subjects--Topical: Chemistry
Description: Malaria retains its position as one of the most highly transferable diseases throughout the world today, with current efforts focused on controlling its spread. A sensitive, asymptomatic-stage detection method is needed to diagnose malaria before ...

Title: Halogenated Tags for the Investigation of Enzyme Specificity
Author: Houde, Hailey
Date Created: 2023
Subjects--Topical: Biochemistry, Chemistry
Description: The bacterial enzyme undecaprenyl pyrophosphate synthase (UppS) is present in most prokaryotes and is needed for bacterial survival. UppS produces the essential lipid carrier, bactoprenyl monophosphate (BP). BP is critical for the structural integ...

Title: INCORPORATION OF FLUORESCENT ANALOGUES IN ISOPRENOID PATHWAYS IN ESCHERICHIA COLI
Author: George, Chelsea
Date Created: 2018
Subjects--Topical: Biochemistry
Description: Bacterial glycans and glycoconjugates have wide diversity compared to their eukaryotic counterparts. While methods have been developed to monitor and track glycans in eukaryotic systems with some success, there are limited methods with which to do...

Title: Study of Enzymes Required for the Synthesis of the Enterobacterial Common Antigen in Vitro
Author: Oliverio, Cassidy
Date Created: 2021
Subjects--Topical: Biology
Description: In recent years, the Center for Disease Control (CDC) has highlighted many bacteria as being either serious or urgent threats in terms of antibiotic resistance such as Salmonella enterica, Klebsiella, and Shigella. These bacteria are all members o...

Title: Utilizing fluorescently tagged undecaprenyl phosphate as a means to study lipid A modification in Bordetella pertussis.
Author: Black, Theresa
Date Created: 2022
Subjects--Topical: Chemistry
Description: Bordetella pertussis is a gram-negative bacterium that is the causative agent of whooping cough, a highly contagious disease that can be fatal in very young children. The outer membrane of the bacteria consists mainly of lipolysaccharide (LPS), an...