Search results | J. Murrey Atkins Library

Title: RECIPROCAL REGULATION OF MYC AND MICRORNA MIR-308 DURING DROSOPHILA EMBRYOGENESIS
Author: Daneshvar, Kaveh
Date Created: 2012
Subjects--Topical: Molecular biology, Biology, Genetics
Description: Myc is a conserved transcription factor with a role in the regulation of genes that are involved in growth and development. The abundance of Myc protein in the cells must be exquisitely controlled to avoid growth abnormalities caused by too much o...

Title: BIOFLAVONOIDS GENISTEIN AND QUERCETIN TRIGGER ALTERNATIVE END JOINING PATHWAY OF DNA REPAIR
Author: GHOSH, ANINDITA
Date Created: 2019
Subjects--Topical: Biology
Description: Faithful repair of chromosomal double-strand breaks (DSBs) is crucial to genome stability and normal cell survival and proliferation. During normal metabolic processes and especially following exposure to DNA damaging agents including irradiation,...

Title: IDENTIFICATION OF EPITHELIAL OVARIAN TUMOR SPECIFIC APTAMERS THAT BIND AND INTERNALIZE INTO TARGET CELLS
Author: Benedetto, Gregory
Date Created: 2015
Subjects--Topical: Chemistry, Biology
Description: New clinical tools that aid in the early diagnosis of ovarian malignancies will significantly help reduce mortality and improve current long-term survival rates. The objective of the work presented here was to identify ovarian tumor specific singl...

Title: EVALUATING BIOFLAVONOID INDUCED DNA DOUBLE-STRAND BREAKS AND CHROMOSOMAL TRANSLOCATIONS
Author: Goodenow, Donna
Date Created: 2020
Subjects--Topical: Biology
Description: Dietary bioflavonoids are a class of chemical compounds found in soy, fruits, vegetables, tea, coffee, wine, and dietary supplements. They are separated into 12 different sub-classes based upon their structure, however only six are dietarily relev...

Title: Common Dietary and Environmental Compounds Promote a Leukemic Translocation in Hematopoietic Stem Cells and Differentiated Cells
Author: Vestal, Carol
Date Created: 2016
Subjects--Topical: Molecular biology, Biology, Genetics
Description: Maternal exposure to topoisomerase II (topoII) inhibitors that are biochemically similar to the chemotherapeutic drug etoposide may promote infant acute leukemia. Several studies have shown that common dietary bioflavonoids as well as benzene meta...

Title: Topoisomerase II Inhibitors Induce an Illegitimate Genome Rearrangement Common in Infant Leukemia
Author: Bariar, Bhawana
Date Created: 2013
Subjects--Topical: Molecular biology
Description: Infant acute leukemias account for ~30% of all malignancy seen in childhood across the Western world. They are aggressive and characterized by rapid onset shortly after birth. The majority of these have rearrangements involving the MLL (mixed line...

Title: Cell Type-Specific Double Strand Break Repair: An Inter-Chromosomal Homologous Recombination Study Using the Rainbow Mouse Model
Author: Lalwani, Kiran
Date Created: 2023
Subjects--Topical: Molecular biology, Cytology, Developmental biology
Description: Faithful repair of DNA lesions is central to maintaining genomic integrity. Illegitimate repair of chromosomal DNA damage, especially double-strand breaks (DSBs), can lead to mutations and genome rearrangements. Homologous recombination (HR) is a ...

Title: The Potential for Genistein, a Topoisomerase II Inhibitor, to Induce Inter-Chromosomal Homologous Recombination.
Author: French, Caroline
Date Created: 2023
Subjects--Topical: Molecular biology
Description: Maintenance of genome integrity is important for preventing mutagenic events and preserving overall cell functionality. DNA damaging agents induce DNA double strand breaks (DSBs) that are repaired through repair pathways non-homologous end-joining...