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BIOFLAVONOIDS GENISTEIN AND QUERCETIN TRIGGER ALTERNATIVE END JOINING PATHWAY OF DNA REPAIR
Title
BIOFLAVONOIDS GENISTEIN AND QUERCETIN TRIGGER ALTERNATIVE END JOINING PATHWAY OF DNA REPAIR
Author
GHOSH, ANINDITA
Date Created
2019
Subjects--Topical
Biology
Description
Faithful repair of chromosomal double-strand breaks (DSBs) is crucial to genome stability and normal cell survival and proliferation. During normal metabolic processes and especially following exposure to DNA damaging agents including irradiation,...
Cell Type-Specific Double Strand Break Repair: An Inter-Chromosomal Homologous Recombination Study Using the Rainbow Mouse Model
Title
Cell Type-Specific Double Strand Break Repair: An Inter-Chromosomal Homologous Recombination Study Using the Rainbow Mouse Model
Author
Lalwani, Kiran
Date Created
2023
Subjects--Topical
Molecular biology, Cytology, Developmental biology
Description
Faithful repair of DNA lesions is central to maintaining genomic integrity. Illegitimate repair of chromosomal DNA damage, especially double-strand breaks (DSBs), can lead to mutations and genome rearrangements. Homologous recombination (HR) is a ...
Common Dietary and Environmental Compounds Promote a Leukemic Translocation in Hematopoietic Stem Cells and Differentiated Cells
Title
Common Dietary and Environmental Compounds Promote a Leukemic Translocation in Hematopoietic Stem Cells and Differentiated Cells
Author
Vestal, Carol
Date Created
2016
Subjects--Topical
Molecular biology, Biology, Genetics
Description
Maternal exposure to topoisomerase II (topoII) inhibitors that are biochemically similar to the chemotherapeutic drug etoposide may promote infant acute leukemia. Several studies have shown that common dietary bioflavonoids as well as benzene meta...
EVALUATING BIOFLAVONOID INDUCED DNA DOUBLE-STRAND BREAKS AND CHROMOSOMAL TRANSLOCATIONS
Title
EVALUATING BIOFLAVONOID INDUCED DNA DOUBLE-STRAND BREAKS AND CHROMOSOMAL TRANSLOCATIONS
Author
Goodenow, Donna
Date Created
2020
Subjects--Topical
Biology
Description
Dietary bioflavonoids are a class of chemical compounds found in soy, fruits, vegetables, tea, coffee, wine, and dietary supplements. They are separated into 12 different sub-classes based upon their structure, however only six are dietarily relev...
IDENTIFICATION OF EPITHELIAL OVARIAN TUMOR SPECIFIC APTAMERS THAT BIND AND INTERNALIZE INTO TARGET CELLS
Title
IDENTIFICATION OF EPITHELIAL OVARIAN TUMOR SPECIFIC APTAMERS THAT BIND AND INTERNALIZE INTO TARGET CELLS
Author
Benedetto, Gregory
Date Created
2015
Subjects--Topical
Chemistry, Biology
Description
New clinical tools that aid in the early diagnosis of ovarian malignancies will significantly help reduce mortality and improve current long-term survival rates. The objective of the work presented here was to identify ovarian tumor specific singl...
RECIPROCAL REGULATION OF MYC AND MICRORNA MIR-308 DURING DROSOPHILA EMBRYOGENESIS
Title
RECIPROCAL REGULATION OF MYC AND MICRORNA MIR-308 DURING DROSOPHILA EMBRYOGENESIS
Author
Daneshvar, Kaveh
Date Created
2012
Subjects--Topical
Molecular biology, Biology, Genetics
Description
Myc is a conserved transcription factor with a role in the regulation of genes that are involved in growth and development. The abundance of Myc protein in the cells must be exquisitely controlled to avoid growth abnormalities caused by too much o...
Topoisomerase II Inhibitors Induce an Illegitimate Genome Rearrangement Common in Infant Leukemia
Title
Topoisomerase II Inhibitors Induce an Illegitimate Genome Rearrangement Common in Infant Leukemia
Author
Bariar, Bhawana
Date Created
2013
Subjects--Topical
Molecular biology
Description
Infant acute leukemias account for ~30% of all malignancy seen in childhood across the Western world. They are aggressive and characterized by rapid onset shortly after birth. The majority of these have rearrangements involving the MLL (mixed line...