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Detrimental brain inflammation and the role of the interleukin 10 family members
Title
Detrimental brain inflammation and the role of the interleukin 10 family members
Author
Burmeister, Amanda
Date Created
2019
Subjects--Topical
Biology
Description
Resident brain cells recognize pathogens and can initiate and/or regulate inflammation. Indeed, we have shown that stimulated glial cells rapidly produce inflammatory mediators, followed by the late production of anti-inflammatory cytokines such a...
Exploring the Immune System using Hybrid Cube Nanoparticles
Title
Exploring the Immune System using Hybrid Cube Nanoparticles
Author
McMillan, Jessica
Date Created
2021
Subjects--Topical
Biochemistry, Nanotechnology, Biology
Description
Nano-sized cubes made from nucleic acid material (NANPs) are ideal scaffolds for therapeutic nucleic acids (TNAs). Both utilize sequence specificity through base-pairing, providing controlled strand interaction, stability, and targeted targeting d...
INVESTIGATING THE ROLE OF NEWLY DESCRIBED CYTOSOLIC PATTERN RECOGNITION RECEPTORS IN PROTECTIVE HOST RESPONSES TO NEUROTROPIC VIRUSES
Title
INVESTIGATING THE ROLE OF NEWLY DESCRIBED CYTOSOLIC PATTERN RECOGNITION RECEPTORS IN PROTECTIVE HOST RESPONSES TO NEUROTROPIC VIRUSES
Author
Crill, Emma
Date Created
2014
Subjects--Topical
Immunology, Virology
Description
The importance of the effector functions performed by glial cells, the resident cells of the CNS possessing immune functions, in abrogating potentially fatal neurotropic viral infections have only recently begun to gain appreciation. These effecto...
Intracellular pattern recognition receptors underlie inflammatory responses of glial cells to central nervous system pathogens
Title
Intracellular pattern recognition receptors underlie inflammatory responses of glial cells to central nervous system pathogens
Author
Sterka, David
Date Created
2009
Subjects--Topical
Cytology
Description
There is growing appreciation that the resident glial cells of the CNS, in particular microglia and astrocytes, are important participants in the generation of inflammation during brain infection. However, the mechanisms by which these cell types ...
Newly described cytosolic pattern recognition receptors mediate inflammatory glial responses to neurotropic viruses
Title
Newly described cytosolic pattern recognition receptors mediate inflammatory glial responses to neurotropic viruses
Author
Furr, Samantha
Date Created
2012
Subjects--Topical
Immunology, Biology
Description
The rapid onset of potentially lethal neuroinflammation is a defining feature of viral encephalitis. Glial cells are ideally positioned to respond to invading pathogens of the central nervous system (CNS) and produce key inflammatory mediators fol...
ROLE OF THE NOVEL DNA SENSORS cGAS, IFI16, AND ZBP1, DURING VIRAL INFECTIONS IN GLIA
Title
ROLE OF THE NOVEL DNA SENSORS cGAS, IFI16, AND ZBP1, DURING VIRAL INFECTIONS IN GLIA
Author
Jeffries, Austin
Date Created
2020
Subjects--Topical
Immunology, Virology, Neurosciences
Description
Viral central nervous system (CNS) infections can lead to life threatening encephalitis and long-term neurological deficits in survivors. Resident CNS cell types, such as astrocytes and microglia, are known to produce key inflammatory and antivira...
Role of the DNA Sensors cGAS and ZBP1 in DNA Damage and Viral Infection
Title
Role of the DNA Sensors cGAS and ZBP1 in DNA Damage and Viral Infection
Author
Suptela, Alexander
Date Created
2023
Subjects--Topical
Immunology, Molecular biology, Neurosciences
Description
Genomic instability is a key driving force for the development and progression of many neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of DNA damage responses (DDRs) is a critical step in maintaining genomic int...
Sexual Dimorphism in Sepsis Susceptibility: Effects of Reproductive Hormones on Pattern Recognition Receptor Expression
Title
Sexual Dimorphism in Sepsis Susceptibility: Effects of Reproductive Hormones on Pattern Recognition Receptor Expression
Author
Rettew, Jennifer
Date Created
2010
Subjects--Topical
Cytology
Description
Sex-based differences in innate immune responses to bacterial infection are evident in human patients and animal models of disease. Females are less susceptible to the development of bacterial infections and subsequent bacteremia and/or sepsis whi...
The induction of type-I interferon responses in primary osteoblasts following staphylococcus aureus infection
Title
The induction of type-I interferon responses in primary osteoblasts following staphylococcus aureus infection
Author
Furr, Kelli
Date Created
2022
Subjects--Topical
Biology
Description
Osteomyelitis is a serious bacterial infection of bone that is associated with progressive inflammatory tissue damage. This condition commonly affects the long bones of children along with the vertebrae and pelvis of adults. Staphylococcus aureus,...