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Polymer Mediated Delivery of Oligonucleotide and Trans Genes Toward More Efficient and Specific Therapies for Dystrophinopathies and Dystroglycanopathies
Title
Polymer Mediated Delivery of Oligonucleotide and Trans Genes Toward More Efficient and Specific Therapies for Dystrophinopathies and Dystroglycanopathies
Author
Tucker, Jason
Date Created
2014
Subjects--Topical
Molecular biology, Biology, Neurosciences
Description
Muscular dystrophies are genetic disorders caused by mutations in more than 30 genes, with no cure or effective treatment. Duchenne muscular dystrophy (DMD) is caused by frame-shift mutations in the dystrophin gene with little or no functional dys...
Role of the DNA Sensors cGAS and ZBP1 in DNA Damage and Viral Infection
Title
Role of the DNA Sensors cGAS and ZBP1 in DNA Damage and Viral Infection
Author
Suptela, Alexander
Date Created
2023
Subjects--Topical
Immunology, Molecular biology, Neurosciences
Description
Genomic instability is a key driving force for the development and progression of many neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of DNA damage responses (DDRs) is a critical step in maintaining genomic int...