Search results | J. Murrey Atkins Library

Title: Abrogating the oncogenic signaling associated with tumor MUC1 in Pancreatic Ductal Adenocarcinoma
Author: Bose, Mukulika
Date Created: 2022
Subjects--Topical: Molecular biology, Biochemistry, Oncology
Description: Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human cancers. The incidence rate of PDA nearly matches its mortality rate and the best treatment till date is surgical resection for which only 25\% are eligible. Tumor recurrence a...

Title: Characterizing a New Regulator of the ATR Signaling Pathway
Author: Biller, Megan
Date Created: 2022
Subjects--Topical: Molecular biology, Biology
Description: Cellular responses to DNA damage and replication stress are coordinated by an intricate network of repair pathways known as the DNA damage response (DDR). Central to the DDR is the essential kinase ataxia telangiectasia mutated and Rad3-related (A...

Title: Hydrogen bond energy-based comparative analysis of protein-ligand interactions and similarity assessment of protein-DNA complex models
Author: Malik, Fareeha
Date Created: 2022
Subjects--Topical: Bioinformatics, Computer science
Description: Hydrogen bonds play a vital role in protein-DNA interactions. In particular, side chain-base hydrogen bonds are crucial to the binding specificity between protein and DNA. Mutations effecting interface hydrogen bonds in protein-DNA complexes have ...