Search results
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Title
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A NOVEL ANTIBODY FOR THE DETECTION AND TREATMENT OF PANCREATIC DUCTAL ADENOCARCINOMA
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Author
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Wu, Shuta
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Date Created
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2017
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Subjects--Topical
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Biology, Oncology
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Description
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Pancreatic ductal adenocarcinoma (PDA) remains the most aggressive cancer with a 5-year survival rate below 10%. Two of the major contributors to this dismal prognosis are late-stage diagnosis and limited treatment options. Common symptoms of PDA ...
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Title
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CO-CHAPERONE REGULATION OF THE RIBONUCLOETIDE REDUCTASE COMPLEX
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Author
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Knighton, Laura
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Date Created
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2020
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Subjects--Topical
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Biology, Biochemistry
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Description
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The molecular chaperone Hsp70 folds a significant proportion of the proteome and is responsible for the activity and stability of many disease-related proteins, including those in cancer. Substantial effort has been devoted to developing a range o...
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Title
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Characterizing a New Regulator of the ATR Signaling Pathway
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Author
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Biller, Megan
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Date Created
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2022
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Subjects--Topical
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Molecular biology, Biology
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Description
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Cellular responses to DNA damage and replication stress are coordinated by an intricate network of repair pathways known as the DNA damage response (DDR). Central to the DDR is the essential kinase ataxia telangiectasia mutated and Rad3-related (A...
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Title
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Evolution and dynamics of transcriptional regulation in bacteria
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Author
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Li, Shan
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Date Created
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2013
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Subjects--Topical
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Computer science, Statistics, Bioinformatics
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Description
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Although transcription is one of the most important biological functions of cells, our understanding of its regulation is still limited. In this dissertation, we have studied the transcriptional regulation in prokaryotes in three aspects. First, w...
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Title
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Insights Into Plasmodium Genetic Changes Related To Malaria Interventions
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Author
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Dieng, Cheikh
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Date Created
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2023
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Subjects--Topical
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Biology, Parasitology, Genetics
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Description
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Over 80% of all malaria deaths occur in children under 5 years of age. Malaria controlstrategies have been progressively shifted to specific populations and/or areas to maximize effectiveness. Malaria is a significant public health problem in Ghan...
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Title
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PRESERVING DIFFERENTIAL PRIVACY IN COMPLEX DATA ANALYSIS
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Author
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Wang, Yue
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Date Created
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2015
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Subjects--Topical
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Computer science, Data sets
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Description
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Omnipresent databases from various resources, such as social networks, electronic commercial websites, and health related wearable devices, have provided researchers with unprecedented opportunities to analyze complex social phenomena. While socie...
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Title
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Role of the DNA Sensors cGAS and ZBP1 in DNA Damage and Viral Infection
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Author
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Suptela, Alexander
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Date Created
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2023
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Subjects--Topical
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Immunology, Molecular biology, Neurosciences
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Description
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Genomic instability is a key driving force for the development and progression of many neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of DNA damage responses (DDRs) is a critical step in maintaining genomic int...
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Title
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Understanding Chaperone interactions in disease
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Author
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Nitika
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Date Created
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2021
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Subjects--Topical
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Molecular biology, Biochemistry, Cytology
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Description
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The correct folding of proteins after synthesis and stress-promoted denaturation is critical for cell viability in all organisms. The Hsp70 molecular chaperone is a key player in proteostasis, deciding which proteins are foldable and which are too...