- Weller, Jennifer (x)
- Tickle, Timothy (x)
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Search results
- Title
- Elucidation of miRNAs in Avena sativa
- Author
- Sheridan, Jaime
- Date Created
- 2014
- Subjects--Topical
- Bioinformatics, Agriculture
- Description
- Micro RNAs (miRNAs) are a class of small non-coding RNAs with post-transcriptional gene regulation responsibilities. In plants, miRNAs regulate development of leaves, roots, shoots, and flowers through targeting families of transcription factors a...
- Title
- Evolution and dynamics of transcriptional regulation in bacteria
- Author
- Li, Shan
- Date Created
- 2013
- Subjects--Topical
- Computer science, Statistics, Bioinformatics
- Description
- Although transcription is one of the most important biological functions of cells, our understanding of its regulation is still limited. In this dissertation, we have studied the transcriptional regulation in prokaryotes in three aspects. First, w...
- Title
- Genomic Dissection of Complex Trait Variation in Wild Soybean, Glycine soja
- Author
- Kofsky, Janice
- Date Created
- 2019
- Subjects--Topical
- Biology, Bioinformatics, Plant diseases
- Description
- There is a considerable demand for crop improvement, especially considering the growing population, continuing climatic fluctuations, and rapidly evolving plant pests and pathogens. Crop wild relatives hold great potential in providing beneficial ...
- Title
- Hydrogen bond energy-based comparative analysis of protein-ligand interactions and similarity assessment of protein-DNA complex models
- Author
- Malik, Fareeha
- Date Created
- 2022
- Subjects--Topical
- Bioinformatics, Computer science
- Description
- Hydrogen bonds play a vital role in protein-DNA interactions. In particular, side chain-base hydrogen bonds are crucial to the binding specificity between protein and DNA. Mutations effecting interface hydrogen bonds in protein-DNA complexes have ...
- Title
- IMPROVING DATA EXTRACTION METHODS FOR LARGE MOLECULAR BIOLOGY DATASETS
- Author
- Reid, Robert
- Date Created
- 2010
- Subjects--Topical
- Bioinformatics
- Description
- ROBERT WILLIAM REID. Improving data extraction methods for large molecular biology datasets. (Under direction of DR. ANTHONY A. FODOR)In the past, an experiment involving a pair wise comparison normally involved one or a few dependent variables. N...
- Title
- MOLECULAR MECHANISMS OF RESISTANCE OF PANCREATIC DUCTAL ADENOCARCINOMA CELLS TO ONCOLYTIC VESICULAR STOMATITIS VIRUS
- Author
- Felt, Sebastien
- Date Created
- 2017
- Subjects--Topical
- Molecular biology, Virology, Cytology
- Description
- Oncolytic virus (OV) therapy is an anticancer therapy using replication-competent viruses selectively infecting, replicating in and killing cancer cells. Human pancreatic ductal adenocarcinoma (PDAC) cell lines are highly heterogeneous in their pe...
- Title
- Structural analysis of protein-DNA binding specificity and its application to protein-DNA docking assessment
- Author
- Corona de la Fuente, Rosario
- Date Created
- 2016
- Subjects--Topical
- Bioinformatics
- Description
- DNA-binding proteins are involved in essential biological processes including gene expression, DNA packaging and DNA repair. They bind to DNA target sequences with different degrees of binding specificity, ranging from highly specific to non-speci...
- Title
- Studies on the relationships between oligonucleotide probe properties and hybridization signal intensities
- Author
- Gharaibeh, Raad
- Date Created
- 2009
- Subjects--Topical
- Computer science, Statistics, Bioinformatics
- Description
- Microarray technology is a commonly used tool in biomedical research for assessing global gene expression, surveying DNA sequence variations, and studying alternative gene splicing. Given the wide range of applications of this technology, comprehe...
- Title
- THE EFFECT OF TARGET SECONDARY STRUCTURE ON MICROARRAY DATA QUALITY
- Author
- Ratushna, Vladyslava
- Date Created
- 2010
- Subjects--Topical
- Bioinformatics, Biophysics
- Description
- DNA microarrays have become an invaluable high throughput biotechnology method, which allows a parallel investigation of thousands of cellular events in a single experiment. The principle behind the technology is very simple: fluorescently labeled...
- Title
- TRANSCRIPTIONAL REGULATION OF GENES ASSOCIATED WITH DRUG RESISTANCE AND GROWTH OF PANCREATIC CANCER CELLS BY MUCIN 1
- Author
- Nath, Sritama
- Date Created
- 2013
- Subjects--Topical
- Molecular biology, Cytology, Oncology
- Description
- Pancreatic ductal adenocarcinoma (PDA) is the 4th leading cause of cancer-related deaths in the US. An understanding of the molecular pathogenesis of PDA is of utmost importance to be able to improve the current or design new targeted therapies fo...
- Title
- The Semantics of Diet and Health: Knowledge Based Discovery Through Data Integration, Text Mining, and Network Analysis
- Author
- Linchangco, Richard
- Date Created
- 2018
- Subjects--Topical
- Bioinformatics
- Description
- Consumption of fruits and vegetables has been linked to a reduced risk of cancer and other chronic diseases, but the molecular mechanisms supporting these connections remain largely unknown. A wealth of association data linking components of a pla...
- Title
- The evolution of flavonoid pathway in legumes
- Author
- Safari, Sajedeh
- Date Created
- 2016
- Subjects--Topical
- Bioinformatics
- Description
- Considering the ever growing world population as well as climate change, it has become essential to improve crops in order to reach higher yields, more tolerance to pests and droughts, and better adaptation to different environments. The advanceme...
- Title
- Toward understanding protein-DNA interactions
- Author
- Lin, Maoxuan
- Date Created
- 2020
- Subjects--Topical
- Biology, Bioinformatics, Biochemistry
- Description
- Knowledge of protein-DNA interactions has important implications in understandingbiological activities and developing therapeutic drugs. Two types of protein-DNAinteractions exist: (1) interactions between double-stranded DNA-binding proteins(DSBs...
- Title
- UNDERSTANDING BIAS IN NEXT-GENERATION SEQUENCING TECHNOLOGIES AND ANALYSES
- Author
- Price, Adam
- Date Created
- 2017
- Subjects--Topical
- Biology, Bioinformatics, Biophysics
- Description
- The problem of bias resulting from biological and technological sources is one that must be consistently reexamined alongside the development of new technologies and methods of analysis. This dissertation addresses the complexities of bias identif...
- Title
- Understanding The Role of Pancreatic Ductal Adenocarcinoma Chemoresistance and Intertumoral Heterogeneity on Vesicular Stomatitis Virus-based Oncolytic Therapy
- Author
- Goad, Dakota
- Date Created
- 2023
- Subjects--Topical
- Biology, Virology, Biomedical engineering
- Description
- Viruses are obligate intracellular parasites that are now being increasingly harnessed as therapeutics for human diseases. Investigating different cellular factors and processes that affect viral infection allows us to improve the efficacy of viru...
- Title
- Understanding and overcoming limitations of vesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinoma
- Author
- Hastie, Eric
- Date Created
- 2014
- Subjects--Topical
- Virology, Biology
- Description
- Vesicular stomatitis virus (VSV) is a prototypic nonsegmented negative-strand RNA virus. Lack of preexisting immunity against VSV, inherent oncotropism, and genetic malleability make VSV a widely used platform for vaccine, oncolytic, and gene ther...
- Title
- Understanding gene transcriptional regulation at single cell resolution
- Author
- Xu, Chen
- Date Created
- 2015
- Subjects--Topical
- Bioinformatics
- Description
- The recent advance of single-cell technologies has provided an unprecedented opportunity to bring new insights into many complex biological phenomena, such as the regulation of cell differentiation in a multi-cellular organism and cell-to-cell var...
- Title
- VIBRIO VULNIFICUS VIRULENCE AND SURVIVAL MECHANISMS REVEALED THROUGH COMPARATIVE MICROBIAL GENOMIC ANALYSIS
- Author
- Morrison, Shatavia
- Date Created
- 2013
- Subjects--Topical
- Bioinformatics
- Description
- A sound genome assembly and robust annotations are essential to the differential analysis of bacterial genomes. Using a case study data set of newly sequenced Vibrio vulnificus genomes, both the biology of these bacteria, and the bioinformatics pr...