Search results
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Title
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Data Mining the Serous Ovarian Tumor Transcriptome
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Author
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Tickle, Timothy
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Date Created
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2011
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Subjects--Topical
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Bioinformatics, Genetics
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Description
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Ovarian cancer is the most lethal gynecologic cancer in the United States. If caught in early stages, patient survival rate is 94%, late stage survival rates drop to 28%. It is because most cases are caught in late stages that high mortality is se...
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Title
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Elucidation of miRNAs in Avena sativa
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Author
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Sheridan, Jaime
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Date Created
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2014
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Subjects--Topical
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Bioinformatics, Agriculture
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Description
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Micro RNAs (miRNAs) are a class of small non-coding RNAs with post-transcriptional gene regulation responsibilities. In plants, miRNAs regulate development of leaves, roots, shoots, and flowers through targeting families of transcription factors a...
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Title
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Evolution and dynamics of transcriptional regulation in bacteria
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Author
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Li, Shan
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Date Created
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2013
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Subjects--Topical
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Computer science, Statistics, Bioinformatics
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Description
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Although transcription is one of the most important biological functions of cells, our understanding of its regulation is still limited. In this dissertation, we have studied the transcriptional regulation in prokaryotes in three aspects. First, w...
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Title
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Genomic Dissection of Complex Trait Variation in Wild Soybean, Glycine soja
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Author
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Kofsky, Janice
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Date Created
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2019
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Subjects--Topical
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Biology, Bioinformatics, Plant diseases
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Description
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There is a considerable demand for crop improvement, especially considering the growing population, continuing climatic fluctuations, and rapidly evolving plant pests and pathogens. Crop wild relatives hold great potential in providing beneficial ...
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Title
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IMPROVING DATA EXTRACTION METHODS FOR LARGE MOLECULAR BIOLOGY DATASETS
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Author
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Reid, Robert
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Date Created
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2010
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Subjects--Topical
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Bioinformatics
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Description
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ROBERT WILLIAM REID. Improving data extraction methods for large molecular biology datasets. (Under direction of DR. ANTHONY A. FODOR)In the past, an experiment involving a pair wise comparison normally involved one or a few dependent variables. N...
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Title
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THE EFFECT OF TARGET SECONDARY STRUCTURE ON MICROARRAY DATA QUALITY
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Author
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Ratushna, Vladyslava
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Date Created
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2010
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Subjects--Topical
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Bioinformatics, Biophysics
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Description
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DNA microarrays have become an invaluable high throughput biotechnology method, which allows a parallel investigation of thousands of cellular events in a single experiment. The principle behind the technology is very simple: fluorescently labeled...
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Title
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The evolution of flavonoid pathway in legumes
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Author
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Safari, Sajedeh
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Date Created
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2016
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Subjects--Topical
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Bioinformatics
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Description
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Considering the ever growing world population as well as climate change, it has become essential to improve crops in order to reach higher yields, more tolerance to pests and droughts, and better adaptation to different environments. The advanceme...
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Title
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Toward understanding protein-DNA interactions
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Author
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Lin, Maoxuan
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Date Created
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2020
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Subjects--Topical
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Biology, Bioinformatics, Biochemistry
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Description
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Knowledge of protein-DNA interactions has important implications in understandingbiological activities and developing therapeutic drugs. Two types of protein-DNAinteractions exist: (1) interactions between double-stranded DNA-binding proteins(DSBs...
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Title
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UNDERSTANDING BIAS IN NEXT-GENERATION SEQUENCING TECHNOLOGIES AND ANALYSES
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Author
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Price, Adam
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Date Created
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2017
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Subjects--Topical
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Biology, Bioinformatics, Biophysics
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Description
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The problem of bias resulting from biological and technological sources is one that must be consistently reexamined alongside the development of new technologies and methods of analysis. This dissertation addresses the complexities of bias identif...
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Title
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Understanding gene transcriptional regulation at single cell resolution
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Author
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Xu, Chen
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Date Created
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2015
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Subjects--Topical
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Bioinformatics
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Description
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The recent advance of single-cell technologies has provided an unprecedented opportunity to bring new insights into many complex biological phenomena, such as the regulation of cell differentiation in a multi-cellular organism and cell-to-cell var...