Search results
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Title
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REGULATION OF ACTOMYOSIN ATPASE
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Author
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Ge, Jinghua
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Date Created
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2016
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Subjects--Topical
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Optics, Physics, Biophysics
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Description
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Myosin is a molecular motor that converts chemical energy to mechanical energy, thus generating force and movement in muscles and cells. Myosin interacts with two ligands, ATP (fuel) and actin filaments (motor’s tracks). Actomyosin interaction is ...
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Title
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ELUCIDATING FUNCTIONAL MECHANISMS IN PROTEINS USING THE DISTANCE CONSTRAINT MODEL
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Author
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Singer, Christopher
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Date Created
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2019
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Subjects--Topical
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Bioinformatics, Biophysics, Physics
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Description
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Protein thermodynamics has been shown to be insightful and illuminating to the functional mechanisms behind biological function. By characterizing proteins and protein families according to their enthalpy and entropy we can make inferences to the ...
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Title
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MACROPHAGES EXPRESSING NEUROPILIN-1 AND BREAST TUMOR PROGRESSION
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Author
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Helms, Rachel
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Date Created
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2015
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Subjects--Topical
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Biology
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Description
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Human breast carcinoma is the most commonly diagnosed cancer in women in the United States with patient mortality primarily resulting from metastasis of breast cancer cells to distant organs. Immune cells, including macrophages, are involved in ca...
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Title
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Development of Silica Based Nanoparticles for Multimodal Therapeutic Delivery
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Author
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Vadarevu, Hemapriyadarshini
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Date Created
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2022
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Subjects--Topical
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Nanoscience
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Description
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Chronic diseases like cancer are characterized by complex interactions between multiple pathways leading to treatment resistance and invasiveness. Repeated cycles of cytotoxic monotherapies are susceptible to drug resistance induced by the upregul...
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Title
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Exceptional New Reagents for Bioconjugation
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Author
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Garmon, Corey
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Date Created
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2016
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Subjects--Topical
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Chemistry, Biochemistry
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Description
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At about the turn of this century the term "click" chemistry came into the common vernacular amongst chemists. "Click" is used to describe reactions that are "spring-loaded" and proceed well in a predictable manner, with no offensive byproduct and...
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Title
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Green Synthesis of Cellulose Graft Copolymers for Anion Exchange Water Purification
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Author
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Schmal, Stephen
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Date Created
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2022
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Subjects--Topical
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Chemistry
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Description
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This thesis describes the synthesis and characterization of novel cellulose graft copolymers that are used for the purification of drinking water. These nanomaterials function as bottle-brush anion-exchange resins with repeating quaternary ammoniu...
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Title
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Chemical Tools for Biology
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Author
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Fessler, Adam
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Date Created
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2017
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Subjects--Topical
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Chemistry
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Description
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Reagents for biotinylation that are innately water-soluble and can be tracked by both UV-vis spectroscopy and fluorescence (330nm/420nm) have been developed. These reagents are based on the isatoic anhydride platform, which gives rise to their val...
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Title
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NUCLEIC ACID-DRIVEN QUANTUM DOT-BASED LATTICE FORMATIONS FOR BIOMEDICAL APPLICATIONS
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Author
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Roark, Brandon
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Date Created
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2017
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Subjects--Topical
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Nanoscience, Nanotechnology, Biochemistry
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Description
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We present a versatile biosensing strategy that uses nucleic acids programmed to undergo an isothermal toehold mediated strand displacement in the presence of analyte. This rearrangement results in a double biotinylated duplex formation that induc...
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Title
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THE ROLE OF OXYGEN ON THE IN VITRO AND IN SITU ECOPHYSIOLOGY OF MARINE VIBRIO SPECIES
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Author
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Phippen, Britney
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Date Created
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2018
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Subjects--Topical
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Microbiology
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Description
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Hypoxia is an emerging concern in coastal ecosystems worldwide, and the number of areas experiencing hypoxia has increased exponentially in recent years. It is most prevalent in summer months when elevated temperatures lead to increased oxygen con...
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Title
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Synthesis, Characterization and Functionalization of Anti-Bisarene Scaffolds
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Author
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Franklin, Joseph
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Date Created
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2017
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Subjects--Topical
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Chemistry
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Description
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Since the advent of rational organic synthesis, practitioners in the field have been refining their craft to target compounds of immense complexity. Synthetic methodologies discovered through these pursuits have provided a fertile ground to expand...