Search results | J. Murrey Atkins Library

Title: Characterization of Dynamic and Functional Nucleic Acid Based Systems
Author: Beasock, Damian
Date Created: 2023
Subjects--Topical: Nanoscience
Description: Nucleic acids are highly integrated into molecular biology and exhibit very interesting character. They have immense engineering potential to improve human health and influence molecular systems. Consequently, these biopolymers are the quintessent...

Title: Design and Modulation of Novel Chemical Probes for RNA SHAPE Analysis: Water Soluble Isatoic Anhydrides and Nicotinic Acid Imidazolides
Author: Fessler, Adam
Date Created: 2021
Subjects--Topical: Chemistry, Biology
Description: The growing interest in RNA biology, along with an expansion in computational capabilities, throughput, and sensitivity has provided researchers new tools to probe RNA. RNA selective 2′-hydroxy acylation analyzed by primer extension (SHAPE) utiliz...

Title: Chemical Tools for Biology
Author: Fessler, Adam
Date Created: 2017
Subjects--Topical: Chemistry
Description: Reagents for biotinylation that are innately water-soluble and can be tracked by both UV-vis spectroscopy and fluorescence (330nm/420nm) have been developed. These reagents are based on the isatoic anhydride platform, which gives rise to their val...

Title: Mass Spectrometric Protein Footprinting of Conformational Changes Induced by Chromatographic Surfaces
Author: Focke, Kimberly
Date Created: 2022
Subjects--Topical: Analytical chemistry, Biochemistry
Description: Reversed-phase liquid chromatography (RPLC) of intact proteins induces conformational changes due to the denaturing effects of both the hydrophobic stationary phase and the high-organic mobile phase, which can lead to poor recovery and badly disto...

Title: LOADED AND ELABORATED POLYESTER NANOMATERIALS FOR THE TREATMENT AND DIAGNOSIS OF DISEASE
Author: Fowler, Anthony
Date Created: 2017
Subjects--Topical: Chemistry, Nanotechnology
Description: Cancer is not one disease but many. In fact, cancer is a collection of more than 100 different diseases. Cancer is the second leading cause of death in the United States with an estimated 1.7 million new cases expected in 2017 and approximately 60...

Title: Synthesis, Characterization and Functionalization of Anti-Bisarene Scaffolds
Author: Franklin, Joseph
Date Created: 2017
Subjects--Topical: Chemistry
Description: Since the advent of rational organic synthesis, practitioners in the field have been refining their craft to target compounds of immense complexity. Synthetic methodologies discovered through these pursuits have provided a fertile ground to expand...

Title: Role of Intramolecular Electrostatic Interactions on the Kinetics of Human Cardiac Myosin β-Isoform
Author: Gargey, Akhil
Date Created: 2021
Subjects--Topical: Molecular biology, Biochemistry, Biophysics
Description: Human cardiac myosin has two isoforms, α and β, sharing significant sequence similarity, but different in kinetics. Small differences in the sequence are responsible for distinct local inter-residue interactions within α and β isoforms, leading to...

Title: Exceptional New Reagents for Bioconjugation
Author: Garmon, Corey
Date Created: 2016
Subjects--Topical: Chemistry, Biochemistry
Description: At about the turn of this century the term "click" chemistry came into the common vernacular amongst chemists. "Click" is used to describe reactions that are "spring-loaded" and proceed well in a predictable manner, with no offensive byproduct and...

Title: REGULATION OF ACTOMYOSIN ATPASE
Author: Ge, Jinghua
Date Created: 2016
Subjects--Topical: Optics, Physics, Biophysics
Description: Myosin is a molecular motor that converts chemical energy to mechanical energy, thus generating force and movement in muscles and cells. Myosin interacts with two ligands, ATP (fuel) and actin filaments (motor’s tracks). Actomyosin interaction is ...

Title: MACROPHAGES EXPRESSING NEUROPILIN-1 AND BREAST TUMOR PROGRESSION
Author: Helms, Rachel
Date Created: 2015
Subjects--Topical: Biology
Description: Human breast carcinoma is the most commonly diagnosed cancer in women in the United States with patient mortality primarily resulting from metastasis of breast cancer cells to distant organs. Immune cells, including macrophages, are involved in ca...

Title: THE SYNTHESIS OF PHOTOSENSITIZERS FOR THE PHOTODYNAMIC INACTIVATION OF ESCHERICHIA COLI
Author: Hurst, Alexandra
Date Created: 2017
Subjects--Topical: Chemistry
Description: The development of antibiotic resistance is a natural phenomenon that occurs when bacteria cells exchange resistant traits amongst each other or when mutations occur during replication. This causes bacteria to be able to withstand attack by antibi...

Title: Influence of Functional Groups on the Photodynamic Therapy and Internalization of Porphyrin Modified Polyhedral Oligomeric Silsesquioxane (POSS) Molecules in Mammalian Cells
Author: Johnston, Alexis
Date Created: 2020
Subjects--Topical: Chemistry, Chemistry, Inorganic, Chemistry, Organic
Description: Polyhedral Oligomeric Silsesquioxane (POSS) molecules are highly ordered organic- inorganic hybrid materials with a cage like core of alternating silicon and oxygen atoms surrounded by eight pedant organic residues. These compounds are well-define...

Title: Synthesis of Asymmetric Thiazolo[5,4-d] Thiazole Derivatives for Molecular Sensing Applications
Author: Meadows, Jared
Date Created: 2021
Subjects--Topical: Chemistry, Biochemistry, Materials science
Description: This thesis outlines the synthesis and characterization of new asymmetrically substituted thiazolo[5,4-d]thiazole (TTz) compounds. This class of compounds contains a central bicyclic heteroaromatic system that is electron-deficient, and when subst...

Title: Dissecting The Salivary Gland: Epithelial-Centered Dysfunction in Primary Sjögren’s Syndrome
Author: Noll, Braxton
Date Created: 2022
Subjects--Topical: Molecular biology
Description: Primary Sjögren’s syndrome (pSS) is an autoimmune disease of exocrine tissues causing dry mouth and eyes, mainly affecting women. A culmination of etiologic events leads to the loss of epithelial homeostasis resulting in the MMP9-mediated destruct...

Title: CHARACTERIZING NEXT-GENERATION SEQUENCING (NGS) PLATFORMS FOR MULTIPLEXED BIOSENSING AND APTAMER DISCOVERY: G-QUADRUPLEX APTAMERS AS A CASE STUDY
Author: Patil, Sushant
Date Created: 2016
Subjects--Topical: Molecular biology, Bioinformatics, Biochemistry
Description: Aptamers are single-stranded DNA or RNA molecules forming unique three dimensional structures that can bind to their targets (generally proteins or metabolites or other nucleic acids) with high specificity and affinity. Screening for aptamers requ...

Title: THE ROLE OF OXYGEN ON THE IN VITRO AND IN SITU ECOPHYSIOLOGY OF MARINE VIBRIO SPECIES
Author: Phippen, Britney
Date Created: 2018
Subjects--Topical: Microbiology
Description: Hypoxia is an emerging concern in coastal ecosystems worldwide, and the number of areas experiencing hypoxia has increased exponentially in recent years. It is most prevalent in summer months when elevated temperatures lead to increased oxygen con...

Title: FACTORS SHED BY BREAST TUMOR CELLS, TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME ACTIVITIES, AND THE GENERATION OF PRO-TUMOR MACROPHAGES
Author: Rego, Stephen
Date Created: 2013
Subjects--Topical: Biology
Description: The role of the tumor microenvironment, especially of tumor associated macrophages (TAMs), in the progression and metastatic spread of breast cancer is well established. TAMs are activated in the breast tumor microenvironment to express primarily ...

Title: NUCLEIC ACID-DRIVEN QUANTUM DOT-BASED LATTICE FORMATIONS FOR BIOMEDICAL APPLICATIONS
Author: Roark, Brandon
Date Created: 2017
Subjects--Topical: Nanoscience, Nanotechnology, Biochemistry
Description: We present a versatile biosensing strategy that uses nucleic acids programmed to undergo an isothermal toehold mediated strand displacement in the presence of analyte. This rearrangement results in a double biotinylated duplex formation that induc...

Title: Assessing the Biological Activities of DNA-Templated Silver Nanoclusters and Furthering the Characterization of Nucleic Acid Nanoparticles
Author: Rolband, Lewis
Date Created: 2023
Subjects--Topical: Biochemistry
Description: DNA and RNA are structurally and functionally diverse biopolymers that haveshown promise in recent years as a powerful biomedical tool, in the form of nucleic acid nanotechnologies. The applications of these technologies include biosensing, diagno...

Title: Synthesis, photophysical characterization, and application of asymmetric thiazolothiazoles as molecular sensors
Author: Sayresmith, Nickolas
Date Created: 2021
Subjects--Topical: Nanoscience, Chemistry
Description: Small molecule fluorophores are critical for fluorescence spectroscopy, and enable the measurement of a wide array of biological processes and dynamics. For many biological sensing applications, the overall efficacy of the fluorophore is closely c...