- Troutman, Jerry (x)
- Nanoscience (x)
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- Title
- Assessing the Biological Activities of DNA-Templated Silver Nanoclusters and Furthering the Characterization of Nucleic Acid Nanoparticles
- Author
- Rolband, Lewis
- Date Created
- 2023
- Subjects--Topical
- Biochemistry
- Description
- DNA and RNA are structurally and functionally diverse biopolymers that haveshown promise in recent years as a powerful biomedical tool, in the form of nucleic acid nanotechnologies. The applications of these technologies include biosensing, diagno...
- Title
- CHARACTERIZING NEXT-GENERATION SEQUENCING (NGS) PLATFORMS FOR MULTIPLEXED BIOSENSING AND APTAMER DISCOVERY: G-QUADRUPLEX APTAMERS AS A CASE STUDY
- Author
- Patil, Sushant
- Date Created
- 2016
- Subjects--Topical
- Molecular biology, Bioinformatics, Biochemistry
- Description
- Aptamers are single-stranded DNA or RNA molecules forming unique three dimensional structures that can bind to their targets (generally proteins or metabolites or other nucleic acids) with high specificity and affinity. Screening for aptamers requ...
- Title
- Chemical Tools for Biology
- Author
- Fessler, Adam
- Date Created
- 2017
- Subjects--Topical
- Chemistry
- Description
- Reagents for biotinylation that are innately water-soluble and can be tracked by both UV-vis spectroscopy and fluorescence (330nm/420nm) have been developed. These reagents are based on the isatoic anhydride platform, which gives rise to their val...
- Title
- Design and Modulation of Novel Chemical Probes for RNA SHAPE Analysis: Water Soluble Isatoic Anhydrides and Nicotinic Acid Imidazolides
- Author
- Fessler, Adam
- Date Created
- 2021
- Subjects--Topical
- Chemistry, Biology
- Description
- The growing interest in RNA biology, along with an expansion in computational capabilities, throughput, and sensitivity has provided researchers new tools to probe RNA. RNA selective 2′-hydroxy acylation analyzed by primer extension (SHAPE) utiliz...
- Title
- Dissecting The Salivary Gland: Epithelial-Centered Dysfunction in Primary Sjögren’s Syndrome
- Author
- Noll, Braxton
- Date Created
- 2022
- Subjects--Topical
- Molecular biology
- Description
- Primary Sjögren’s syndrome (pSS) is an autoimmune disease of exocrine tissues causing dry mouth and eyes, mainly affecting women. A culmination of etiologic events leads to the loss of epithelial homeostasis resulting in the MMP9-mediated destruct...
- Title
- ELUCIDATING FUNCTIONAL MECHANISMS IN PROTEINS USING THE DISTANCE CONSTRAINT MODEL
- Author
- Singer, Christopher
- Date Created
- 2019
- Subjects--Topical
- Bioinformatics, Biophysics, Physics
- Description
- Protein thermodynamics has been shown to be insightful and illuminating to the functional mechanisms behind biological function. By characterizing proteins and protein families according to their enthalpy and entropy we can make inferences to the ...
- Title
- Exceptional New Reagents for Bioconjugation
- Author
- Garmon, Corey
- Date Created
- 2016
- Subjects--Topical
- Chemistry, Biochemistry
- Description
- At about the turn of this century the term "click" chemistry came into the common vernacular amongst chemists. "Click" is used to describe reactions that are "spring-loaded" and proceed well in a predictable manner, with no offensive byproduct and...
- Title
- FACTORS SHED BY BREAST TUMOR CELLS, TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME ACTIVITIES, AND THE GENERATION OF PRO-TUMOR MACROPHAGES
- Author
- Rego, Stephen
- Date Created
- 2013
- Subjects--Topical
- Biology
- Description
- The role of the tumor microenvironment, especially of tumor associated macrophages (TAMs), in the progression and metastatic spread of breast cancer is well established. TAMs are activated in the breast tumor microenvironment to express primarily ...
- Title
- Green Synthesis of Cellulose Graft Copolymers for Anion Exchange Water Purification
- Author
- Schmal, Stephen
- Date Created
- 2022
- Subjects--Topical
- Chemistry
- Description
- This thesis describes the synthesis and characterization of novel cellulose graft copolymers that are used for the purification of drinking water. These nanomaterials function as bottle-brush anion-exchange resins with repeating quaternary ammoniu...
- Title
- INVESTIGATING THE ECOLOGICAL, PATHOGENIC, AND DORMANT LIFESTYLES OF THE ESTUARINE BACTERIUM, VIBRIO VULNIFICUS
- Author
- Williams, Tiffany
- Date Created
- 2015
- Subjects--Topical
- Microbiology, Bioinformatics
- Description
- Vibrio vulnificus is ubiquitous in estuarine and coastal waters worldwide and associates naturally with a variety of aquatic organisms. Notably, it is a highly invasive human pathogen capable of causing septicemia and multi-organ failure in person...
- Title
- Influence of Functional Groups on the Photodynamic Therapy and Internalization of Porphyrin Modified Polyhedral Oligomeric Silsesquioxane (POSS) Molecules in Mammalian Cells
- Author
- Johnston, Alexis
- Date Created
- 2020
- Subjects--Topical
- Chemistry, Chemistry, Inorganic, Chemistry, Organic
- Description
- Polyhedral Oligomeric Silsesquioxane (POSS) molecules are highly ordered organic- inorganic hybrid materials with a cage like core of alternating silicon and oxygen atoms surrounded by eight pedant organic residues. These compounds are well-define...
- Title
- LOADED AND ELABORATED POLYESTER NANOMATERIALS FOR THE TREATMENT AND DIAGNOSIS OF DISEASE
- Author
- Fowler, Anthony
- Date Created
- 2017
- Subjects--Topical
- Chemistry, Nanotechnology
- Description
- Cancer is not one disease but many. In fact, cancer is a collection of more than 100 different diseases. Cancer is the second leading cause of death in the United States with an estimated 1.7 million new cases expected in 2017 and approximately 60...
- Title
- MACROPHAGES EXPRESSING NEUROPILIN-1 AND BREAST TUMOR PROGRESSION
- Author
- Helms, Rachel
- Date Created
- 2015
- Subjects--Topical
- Biology
- Description
- Human breast carcinoma is the most commonly diagnosed cancer in women in the United States with patient mortality primarily resulting from metastasis of breast cancer cells to distant organs. Immune cells, including macrophages, are involved in ca...
- Title
- Mass Spectrometric Protein Footprinting of Conformational Changes Induced by Chromatographic Surfaces
- Author
- Focke, Kimberly
- Date Created
- 2022
- Subjects--Topical
- Analytical chemistry, Biochemistry
- Description
- Reversed-phase liquid chromatography (RPLC) of intact proteins induces conformational changes due to the denaturing effects of both the hydrophobic stationary phase and the high-organic mobile phase, which can lead to poor recovery and badly disto...
- Title
- REGULATION OF ACTOMYOSIN ATPASE
- Author
- Ge, Jinghua
- Date Created
- 2016
- Subjects--Topical
- Optics, Physics, Biophysics
- Description
- Myosin is a molecular motor that converts chemical energy to mechanical energy, thus generating force and movement in muscles and cells. Myosin interacts with two ligands, ATP (fuel) and actin filaments (motor’s tracks). Actomyosin interaction is ...
- Title
- Role of Intramolecular Electrostatic Interactions on the Kinetics of Human Cardiac Myosin β-Isoform
- Author
- Gargey, Akhil
- Date Created
- 2021
- Subjects--Topical
- Molecular biology, Biochemistry, Biophysics
- Description
- Human cardiac myosin has two isoforms, α and β, sharing significant sequence similarity, but different in kinetics. Small differences in the sequence are responsible for distinct local inter-residue interactions within α and β isoforms, leading to...
- Title
- Synthesis of Asymmetric Thiazolo[5,4-d] Thiazole Derivatives for Molecular Sensing Applications
- Author
- Meadows, Jared
- Date Created
- 2021
- Subjects--Topical
- Chemistry, Biochemistry, Materials science
- Description
- This thesis outlines the synthesis and characterization of new asymmetrically substituted thiazolo[5,4-d]thiazole (TTz) compounds. This class of compounds contains a central bicyclic heteroaromatic system that is electron-deficient, and when subst...
- Title
- Synthesis, Characterization and Functionalization of Anti-Bisarene Scaffolds
- Author
- Franklin, Joseph
- Date Created
- 2017
- Subjects--Topical
- Chemistry
- Description
- Since the advent of rational organic synthesis, practitioners in the field have been refining their craft to target compounds of immense complexity. Synthetic methodologies discovered through these pursuits have provided a fertile ground to expand...
- Title
- THE ROLE OF OXYGEN ON THE IN VITRO AND IN SITU ECOPHYSIOLOGY OF MARINE VIBRIO SPECIES
- Author
- Phippen, Britney
- Date Created
- 2018
- Subjects--Topical
- Microbiology
- Description
- Hypoxia is an emerging concern in coastal ecosystems worldwide, and the number of areas experiencing hypoxia has increased exponentially in recent years. It is most prevalent in summer months when elevated temperatures lead to increased oxygen con...
- Title
- THE SYNTHESIS OF PHOTOSENSITIZERS FOR THE PHOTODYNAMIC INACTIVATION OF ESCHERICHIA COLI
- Author
- Hurst, Alexandra
- Date Created
- 2017
- Subjects--Topical
- Chemistry
- Description
- The development of antibiotic resistance is a natural phenomenon that occurs when bacteria cells exchange resistant traits amongst each other or when mutations occur during replication. This causes bacteria to be able to withstand attack by antibi...