Search results
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Title
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Characterization of Dynamic and Functional Nucleic Acid Based Systems
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Author
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Beasock, Damian
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Date Created
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2023
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Subjects--Topical
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Nanoscience
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Description
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Nucleic acids are highly integrated into molecular biology and exhibit very interesting character. They have immense engineering potential to improve human health and influence molecular systems. Consequently, these biopolymers are the quintessent...
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Title
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Chemical Tools for Biology
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Author
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Fessler, Adam
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Date Created
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2017
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Subjects--Topical
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Chemistry
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Description
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Reagents for biotinylation that are innately water-soluble and can be tracked by both UV-vis spectroscopy and fluorescence (330nm/420nm) have been developed. These reagents are based on the isatoic anhydride platform, which gives rise to their val...
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Title
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Development of Silica Based Nanoparticles for Multimodal Therapeutic Delivery
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Author
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Vadarevu, Hemapriyadarshini
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Date Created
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2022
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Subjects--Topical
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Nanoscience
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Description
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Chronic diseases like cancer are characterized by complex interactions between multiple pathways leading to treatment resistance and invasiveness. Repeated cycles of cytotoxic monotherapies are susceptible to drug resistance induced by the upregul...
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Title
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ELUCIDATING FUNCTIONAL MECHANISMS IN PROTEINS USING THE DISTANCE CONSTRAINT MODEL
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Author
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Singer, Christopher
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Date Created
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2019
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Subjects--Topical
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Bioinformatics, Biophysics, Physics
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Description
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Protein thermodynamics has been shown to be insightful and illuminating to the functional mechanisms behind biological function. By characterizing proteins and protein families according to their enthalpy and entropy we can make inferences to the ...
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Title
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Exceptional New Reagents for Bioconjugation
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Author
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Garmon, Corey
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Date Created
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2016
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Subjects--Topical
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Chemistry, Biochemistry
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Description
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At about the turn of this century the term "click" chemistry came into the common vernacular amongst chemists. "Click" is used to describe reactions that are "spring-loaded" and proceed well in a predictable manner, with no offensive byproduct and...
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Title
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Green Synthesis of Cellulose Graft Copolymers for Anion Exchange Water Purification
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Author
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Schmal, Stephen
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Date Created
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2022
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Subjects--Topical
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Chemistry
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Description
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This thesis describes the synthesis and characterization of novel cellulose graft copolymers that are used for the purification of drinking water. These nanomaterials function as bottle-brush anion-exchange resins with repeating quaternary ammoniu...
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Title
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LOADED AND ELABORATED POLYESTER NANOMATERIALS FOR THE TREATMENT AND DIAGNOSIS OF DISEASE
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Author
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Fowler, Anthony
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Date Created
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2017
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Subjects--Topical
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Chemistry, Nanotechnology
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Description
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Cancer is not one disease but many. In fact, cancer is a collection of more than 100 different diseases. Cancer is the second leading cause of death in the United States with an estimated 1.7 million new cases expected in 2017 and approximately 60...
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Title
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MACROPHAGES EXPRESSING NEUROPILIN-1 AND BREAST TUMOR PROGRESSION
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Author
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Helms, Rachel
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Date Created
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2015
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Subjects--Topical
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Biology
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Description
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Human breast carcinoma is the most commonly diagnosed cancer in women in the United States with patient mortality primarily resulting from metastasis of breast cancer cells to distant organs. Immune cells, including macrophages, are involved in ca...
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Title
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NUCLEIC ACID-DRIVEN QUANTUM DOT-BASED LATTICE FORMATIONS FOR BIOMEDICAL APPLICATIONS
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Author
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Roark, Brandon
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Date Created
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2017
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Subjects--Topical
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Nanoscience, Nanotechnology, Biochemistry
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Description
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We present a versatile biosensing strategy that uses nucleic acids programmed to undergo an isothermal toehold mediated strand displacement in the presence of analyte. This rearrangement results in a double biotinylated duplex formation that induc...
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Title
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REGULATION OF ACTOMYOSIN ATPASE
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Author
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Ge, Jinghua
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Date Created
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2016
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Subjects--Topical
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Optics, Physics, Biophysics
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Description
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Myosin is a molecular motor that converts chemical energy to mechanical energy, thus generating force and movement in muscles and cells. Myosin interacts with two ligands, ATP (fuel) and actin filaments (motor’s tracks). Actomyosin interaction is ...