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Development of Silica Based Nanoparticles for Multimodal Therapeutic Delivery
Title
Development of Silica Based Nanoparticles for Multimodal Therapeutic Delivery
Author
Vadarevu, Hemapriyadarshini
Date Created
2022
Subjects--Topical
Nanoscience
Description
Chronic diseases like cancer are characterized by complex interactions between multiple pathways leading to treatment resistance and invasiveness. Repeated cycles of cytotoxic monotherapies are susceptible to drug resistance induced by the upregul...
Quantifying the Binding Affinities of the PAI-H19Y Mutant of Sleeping Beauty Transposase to DNA
Title
Quantifying the Binding Affinities of the PAI-H19Y Mutant of Sleeping Beauty Transposase to DNA
Author
Arango, Maria
Date Created
2022
Subjects--Topical
Physics
Description
The Sleeping Beauty (SB) transposon system is the leading and only DNA transposon-based gene-delivery vehicle that has been adapted for human gene therapy. The SB system consists of a transposon DNA flanked by inverted terminal repeats (ITRs) and ...