Search results
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Title
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ALGORITHMS FOR STRUCTURE BASED-PREDICTION OF TRANSCRIPTION FACTOR BINDING SITES
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Author
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Farrel, Alvin
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Date Created
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2016
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Subjects--Topical
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Computer science, Biology, Bioinformatics
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Description
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Transcription factors (TFs) regulate gene expression through binding to specific target DNA sites. Accurate annotation of transcription factor binding sites (TFBSs) at genome scale represents an essential step toward our understanding of gene regu...
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Title
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Mechanisms of acclimation and adaptation in the sea urchin Echinometra sp. EZ
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Author
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Ketchum, Remi
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Date Created
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2017
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Subjects--Topical
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Biology
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Description
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Climate change has resulted in warming of coastal aquatic habitats around the world at almost every latitude, threatening ecosystems with a significant loss in biodiversity and occurring at a rate that may exceed species’ ability to adapt. Underst...
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Title
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Toward understanding protein-DNA interactions
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Author
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Lin, Maoxuan
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Date Created
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2020
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Subjects--Topical
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Biology, Bioinformatics, Biochemistry
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Description
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Knowledge of protein-DNA interactions has important implications in understandingbiological activities and developing therapeutic drugs. Two types of protein-DNAinteractions exist: (1) interactions between double-stranded DNA-binding proteins(DSBs...
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Title
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DE NOVO PREDICTION OF CIS-REGULATORY MODULES IN EUKARYOTIC ORGANISMS
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Author
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Niu, Meng
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Date Created
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2014
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Subjects--Topical
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Bioinformatics
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Description
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Gene regulation networks (GRNs) are the bases for virtually all biological processes. To gain a global understanding of GRNs encoded in a genome, we first need to identify in all the cis-regulatory elements (CREs) recognized by transcription facto...
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Title
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INVESTIGATING THE GENETIC BASIS OF GENE EXPRESSION USING EQTL TECHNIQUES
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Author
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Quitadamo, Andrew
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Date Created
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2018
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Subjects--Topical
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Bioinformatics
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Description
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With advances in genome sequencing technology, datasets with large sample sizes can be generated relatively quickly and cheaply, especially compared to the past decade or so. We can utilize this data to analyze the associations between genetic var...
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Title
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The evolution of flavonoid pathway in legumes
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Author
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Safari, Sajedeh
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Date Created
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2016
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Subjects--Topical
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Bioinformatics
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Description
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Considering the ever growing world population as well as climate change, it has become essential to improve crops in order to reach higher yields, more tolerance to pests and droughts, and better adaptation to different environments. The advanceme...
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Title
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UNDERSTANDING GENOME-WIDE GENE REGULATION IN PROKARYOTES USING OMICS DATA
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Author
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Seyedi Tabari, Seyed Ehsan
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Date Created
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2016
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Subjects--Topical
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Bioinformatics, Information science, Biometry
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Description
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Gene annotation is a critical step for understanding functions of genomes and host organisms. However, accurately annotating thousands of sequenced genomes can be a challenging task. Further, although gene transcriptional regulation is crucial for...
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Title
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Understanding gene transcriptional regulation at single cell resolution
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Author
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Xu, Chen
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Date Created
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2015
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Subjects--Topical
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Bioinformatics
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Description
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The recent advance of single-cell technologies has provided an unprecedented opportunity to bring new insights into many complex biological phenomena, such as the regulation of cell differentiation in a multi-cellular organism and cell-to-cell var...
