Search results | J. Murrey Atkins Library

Title: EFFECTS OF SILIBININ ON ETHANOL-MEDIATED HEPATOCELLULAR CARCINOMA PROGRESSION IN MALE AND FEMALE MICE
Author: Warner, Elizabeth
Date Created: 2011
Subjects--Topical: Biology
Description: Ethanol is a significant risk for the development of hepatic cirrhosis and progression to hepatocellular carcinoma (HCC). While females are more susceptible to the deleterious effects of ethanol, the incidence of cirrhosis and HCC is significantly...

Title: EXPERIMENTAL AND COMPUTATIONAL STRATEGIES FOR ENHANCING MASS TRANSPORT AND CRYOPRESERVATION OF BIOLOGICAL TISSUES
Author: Karthik Kumar, Balasubramanian
Date Created: 2012
Subjects--Topical: Mechanical engineering, Biomedical engineering
Description: A bioreactor is a large-scale engineered in vitro device that maintains a 3D arrangement of functioning cells for use in various bioengineering applications. The current work is focused on heat and mass transfer issues related to the bioreactor's ...

Title: FACTORS SHED BY BREAST TUMOR CELLS, TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME ACTIVITIES, AND THE GENERATION OF PRO-TUMOR MACROPHAGES
Author: Rego, Stephen
Date Created: 2013
Subjects--Topical: Biology
Description: The role of the tumor microenvironment, especially of tumor associated macrophages (TAMs), in the progression and metastatic spread of breast cancer is well established. TAMs are activated in the breast tumor microenvironment to express primarily ...

Title: HOST FACTORS CONTROLLING VIRUS INFECTION: IMPLICATIONS FOR ANTIVIRALS AND VIROTHERAPY
Author: Shah, Nirav
Date Created: 2013
Subjects--Topical: Virology, Oncology
Description: Viruses are obligate intracellular parasites rely heavily on host components and pathways for their replication. Studying different cellular factors affecting viral infection can enable us to identify novel drug targets, improve current antiviral ...

Title: IDENTIFICATION OF EPITHELIAL OVARIAN TUMOR SPECIFIC APTAMERS THAT BIND AND INTERNALIZE INTO TARGET CELLS
Author: Benedetto, Gregory
Date Created: 2015
Subjects--Topical: Chemistry, Biology
Description: New clinical tools that aid in the early diagnosis of ovarian malignancies will significantly help reduce mortality and improve current long-term survival rates. The objective of the work presented here was to identify ovarian tumor specific singl...

Title: NOVEL ROLES OF MICRORNAS IN HEPATITIS C
Author: Sendi, Hossein
Date Created: 2013
Subjects--Topical: Virology, Biology
Description: Approximately, 170 million people are infected by hepatitis C virus (HCV) worldwide, and of these, nearly 85% will develop chronic hepatitis C (CHC). Despite finding new anti-viral treatment that increase response rate from 45 % to 65-70 %, invest...

Title: Nonsegmented negative strand RNA viruses: viral RNA cap methylation and potential applications as an anticancer therapy
Author: Murphy, Andrea
Date Created: 2012
Subjects--Topical: Virology, Biology
Description: The viruses of the order Mononegavirales include important human, animal, and plant pathogens and additionally, have great potential as vaccine, oncolytic and gene therapy vectors. This dissertation focuses on two prototypic Mononegavirales, vesic...

Title: Production of Immunomodulatory Proteins in Glycine max for use in Diagnostics and as Therapeutics
Author: Powell, Rebecca
Date Created: 2010
Subjects--Topical: Molecular biology
Description: ABSTRACTREBECCA DIANE POWELL. Production of Immunomodulatory Proteins in Glycine max for Use in Diagnostics and as Therapeutics. (Under the direction of DR. KENNETH L. BOST) Immunomodulatory proteins can be utilized in diagnostic assays, as tolera...

Title: ROLE OF AQUAPORINS DURING HEPATOCELLULAR CARCINOMA INITIATION AND PROGRESSION
Author: Mattocks, Matthew
Date Created: 2010
Subjects--Topical: Molecular biology, Cytology, Oncology
Description: Aquaporins (AQPs) are ubiquitously expressed proteinaceous water channels involved in numerous physiological processes including bile production and apoptosis. Aquaporins 8 and 9 are expressed in hepatocytes, and are down regulated in a rat model ...

Title: Regulation of Myosin IIIa Motor/Kinase Activity
Author: Moore, Judy
Date Created: 2009
Subjects--Topical: Biochemistry, Neurosciences, Cytology
Description: Myosin IIIa, a motor protein that localizes to actin-rich regions of photoreceptors and to stereocilia of inner ear hair cells, is associated with the hearing process in vertebrates and with phototransduction for invertebrates. It contains a large...

Title: The role of the dopaminergic system in the regulation of physical activity in mice
Author: Knab, Amy
Date Created: 2009
Subjects--Topical: Molecular biology, Genetics, Physiology
Description: Physical activity (PA) is important to human health, and the genetic and biological regulating factors of physical activity are only beginning to be understood. The dopamine (DA) system has been shown to regulate motivation, and locomotor behavior...

Title: Topoisomerase II Inhibitors Induce an Illegitimate Genome Rearrangement Common in Infant Leukemia
Author: Bariar, Bhawana
Date Created: 2013
Subjects--Topical: Molecular biology
Description: Infant acute leukemias account for ~30% of all malignancy seen in childhood across the Western world. They are aggressive and characterized by rapid onset shortly after birth. The majority of these have rearrangements involving the MLL (mixed line...