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A NOVEL ANTIBODY FOR THE DETECTION AND TREATMENT OF PANCREATIC DUCTAL ADENOCARCINOMA
Title
A NOVEL ANTIBODY FOR THE DETECTION AND TREATMENT OF PANCREATIC DUCTAL ADENOCARCINOMA
Author
Wu, Shuta
Date Created
2017
Subjects--Topical
Biology, Oncology
Description
Pancreatic ductal adenocarcinoma (PDA) remains the most aggressive cancer with a 5-year survival rate below 10%. Two of the major contributors to this dismal prognosis are late-stage diagnosis and limited treatment options. Common symptoms of PDA ...
Analysis and Development of Targeting Strategies for Bacterial Sugars
Title
Analysis and Development of Targeting Strategies for Bacterial Sugars
Author
Erickson, Katelyn
Date Created
2018
Subjects--Topical
Chemistry, Biochemistry
Description
Bacterial cell surface exopolysaccharides aid in protecting microbes from the defense mechanisms of the host, and differ substantially in structure between species. Exploiting these structural differences would be advantageous to target certain ty...
Approaches for Power Grid Management and Ancillary Services with DC-AC Micro-grids Comprising of PV Farm and Hybrid Energy Storage System
Title
Approaches for Power Grid Management and Ancillary Services with DC-AC Micro-grids Comprising of PV Farm and Hybrid Energy Storage System
Author
Joshi, Aniket
Date Created
2021
Subjects--Topical
Electrical engineering
Description
The emergence of the concept of DC grids comes from the fact that there is an increasing number of power grid components that naturally operate with DC power. The combined trend of DC sources and loads in power grids is an important player in the ...
Chemoenzymatic Preparation of Probes for in vitro and Cellular Elucidation of Complex Bacteria Polysaccharides
Title
Chemoenzymatic Preparation of Probes for in vitro and Cellular Elucidation of Complex Bacteria Polysaccharides
Author
Reid, Amanda
Date Created
2021
Subjects--Topical
Microbiology, Biochemistry, Analytical chemistry
Description
Bacteria play a major role in our health and wellbeing. The microbe-host interaction is often mediated by sugar polymers at the cell surface. An incredibly diverse amount of glycan variation exists throughout these structures, which makes identifi...
Long-term study of changes in microbiota in a Cystic Fibrosis patient
Title
Long-term study of changes in microbiota in a Cystic Fibrosis patient
Author
Stokell, Joshua
Date Created
2013
Subjects--Topical
Biology, Microbiology
Description
Application of culture-independent techniques have revealed the presence of more types of bacteria than were previously thought, which led to the current description of Cystic Fibrosis (CF) being a polymicrobial disease. We know this polymicrobial...
RANK-L expression in Staphylococcus aureus- induced osteomyelitis, therapeutic intervention using nanotechnology and use of UV-killed bacteria as an osteoconductive coating for biomaterials.
Title
RANK-L expression in Staphylococcus aureus- induced osteomyelitis, therapeutic intervention using nanotechnology and use of UV-killed bacteria as an osteoconductive coating for biomaterials.
Author
Somayaji, Shankari
Date Created
2009
Subjects--Topical
Microbiology
Description
Staphylococcus aureus is responsible for approximately 80% of all cases of human osteomyelitis. RANK-L is an essential signal produced by osteoblasts and is required for full osteoclastic differentiation. PGE2 - induced bone resorption involves bo...
SYNTHESIS, CHARACTERIZATION, AND APPLICATION OF SILICA-BASED NANOPARTICULATE PLATFORMS FOR THE DELIVERY OF PHOTOSENSITIZERS IN THE USE OF PHOTODYNAMIC THERAPY FOR CANCER TREATMENT
Title
SYNTHESIS, CHARACTERIZATION, AND APPLICATION OF SILICA-BASED NANOPARTICULATE PLATFORMS FOR THE DELIVERY OF PHOTOSENSITIZERS IN THE USE OF PHOTODYNAMIC THERAPY FOR CANCER TREATMENT
Author
Lyles, Zachary
Date Created
2018
Subjects--Topical
Nanoscience
Description
Triple negative breast cancer (TNBC) is a subtype of breast cancer which lacks expressions of hormonal receptors (ER/PR/HER2) and other meaningful targets. TNBC is characterized by intra-tumoral heterogeneities, high proliferative activity, poor p...
THE DEVELOPMENT OF NOVEL THERAPEUTICS IN PANCREATIC AND BREAST CANCERS: POTENTIAL ROLE OF MUC1
Title
THE DEVELOPMENT OF NOVEL THERAPEUTICS IN PANCREATIC AND BREAST CANCERS: POTENTIAL ROLE OF MUC1
Author
Besmer, Dahlia
Date Created
2013
Subjects--Topical
Biology
Description
Pancreatic ductal adenocarcinoma (PDA) is the 4th leading cause of cancer-related deaths in the US, and breast cancer (BC) contributes to ~40,000 deaths annually. The development of novel therapeutic agents for improving patient outcome is of para...
THE ROLE OF MUC1 IN REGULATION AND PROGRESSION OF CANCER
Title
THE ROLE OF MUC1 IN REGULATION AND PROGRESSION OF CANCER
Author
Sahraeimanouchehrabadi, Mahnaz
Date Created
2011
Subjects--Topical
Immunology, Biology, Oncology
Description
MUC1 is a heavily glycosylated transmembrane glycoprotein which is overexpressed and aberrantly glycosylated in most human carcinomas. MUC1 contains a large tandem repeat, a short transmembrane, and a small cytoplasmic tail. Both tandem repeat and...