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DO DYNAMIC ALLOSTERIC EFFECTS OCCUR IN IGG4 ANTIBODIES?
Title
DO DYNAMIC ALLOSTERIC EFFECTS OCCUR IN IGG4 ANTIBODIES?
Author
Baker, Lonnie
Date Created
2020
Subjects--Topical
Bioinformatics, Biophysics
Description
Antibodies are large, multi-chain proteins which play a critical roll in the func-tioning of vertebrate immune systems. Immune effector cells which are responsiblefor the destruction of foreign antigens do not randomly target molecules but rely on...
ESSENTIAL DYNAMICS OF PROTEINS USING GEOMETRICAL SIMULATIONS AND SUBSPACE ANALYSIS
Title
ESSENTIAL DYNAMICS OF PROTEINS USING GEOMETRICAL SIMULATIONS AND SUBSPACE ANALYSIS
Author
David, Charles
Date Created
2012
Subjects--Topical
Physics, Bioinformatics, Biophysics
Description
Essential dynamics is the application of principal component analysis to a dynamic trajectory derived from a simulation protocol in order to extract biologically relevant information contained in the high dimensional data. In this work, we apply t...
Elucidating Dynamic Mechanisms for Extended Spectrum Antibiotic Resistance in Class A Beta-Lactamase through Machine Learning on Molecular Dynamics Simulations
Title
Elucidating Dynamic Mechanisms for Extended Spectrum Antibiotic Resistance in Class A Beta-Lactamase through Machine Learning on Molecular Dynamics Simulations
Author
Avery, Christopher
Date Created
2019
Subjects--Topical
Biophysics, Physics
Description
Beta-lactamase is a protein which is produced in bacteria and is a primary cause of antibiotic resistance to Beta Lactam antibiotics. Beta Lactams are among the most common types of antibiotics (including penicillin) and thus understanding the res...
SUBSURFACE THERMAL COAGULATION OF TISSUES USING NEAR INFRARED LASERS
Title
SUBSURFACE THERMAL COAGULATION OF TISSUES USING NEAR INFRARED LASERS
Author
Chang, Chun-Hung
Date Created
2017
Subjects--Topical
Optics, Biophysics, Biomedical engineering
Description
Noninvasive laser therapy is currently limited primarily to cosmetic dermatological applications such as skin resurfacing, hair removal, tattoo removal and treatment of vascular birthmarks. In order to expand applications of noninvasive laser ther...