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Development of Silica Based Nanoparticles for Multimodal Therapeutic Delivery
Title
Development of Silica Based Nanoparticles for Multimodal Therapeutic Delivery
Author
Vadarevu, Hemapriyadarshini
Date Created
2022
Subjects--Topical
Nanoscience
Description
Chronic diseases like cancer are characterized by complex interactions between multiple pathways leading to treatment resistance and invasiveness. Repeated cycles of cytotoxic monotherapies are susceptible to drug resistance induced by the upregul...
Mass Spectrometric Protein Footprinting of Conformational Changes Induced by Chromatographic Surfaces
Title
Mass Spectrometric Protein Footprinting of Conformational Changes Induced by Chromatographic Surfaces
Author
Focke, Kimberly
Date Created
2022
Subjects--Topical
Analytical chemistry, Biochemistry
Description
Reversed-phase liquid chromatography (RPLC) of intact proteins induces conformational changes due to the denaturing effects of both the hydrophobic stationary phase and the high-organic mobile phase, which can lead to poor recovery and badly disto...