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Detrimental brain inflammation and the role of the interleukin 10 family members
Title
Detrimental brain inflammation and the role of the interleukin 10 family members
Author
Burmeister, Amanda
Date Created
2019
Subjects--Topical
Biology
Description
Resident brain cells recognize pathogens and can initiate and/or regulate inflammation. Indeed, we have shown that stimulated glial cells rapidly produce inflammatory mediators, followed by the late production of anti-inflammatory cytokines such a...
EFFECTS OF S-ADENOSYL-L-METHIONINE ON COLLAGEN EXPRESSION IN ACTIVATED HEPATIC STELLATE CELLS
Title
EFFECTS OF S-ADENOSYL-L-METHIONINE ON COLLAGEN EXPRESSION IN ACTIVATED HEPATIC STELLATE CELLS
Author
Thompson, Kyle
Date Created
2009
Subjects--Topical
Biology, Cytology
Description
Liver fibrosis is defined as the excessive accumulation of extracellular matrix (ECM) components, which can disrupt the normal liver microcirculation and lead to injury. Unresolved, hepatic fibrosis can progress to cirrhosis, an end-state liver di...
IDENTIFICATION OF EPITHELIAL OVARIAN TUMOR SPECIFIC APTAMERS THAT BIND AND INTERNALIZE INTO TARGET CELLS
Title
IDENTIFICATION OF EPITHELIAL OVARIAN TUMOR SPECIFIC APTAMERS THAT BIND AND INTERNALIZE INTO TARGET CELLS
Author
Benedetto, Gregory
Date Created
2015
Subjects--Topical
Chemistry, Biology
Description
New clinical tools that aid in the early diagnosis of ovarian malignancies will significantly help reduce mortality and improve current long-term survival rates. The objective of the work presented here was to identify ovarian tumor specific singl...
INVESTIGATING THE ROLE OF NEWLY DESCRIBED CYTOSOLIC PATTERN RECOGNITION RECEPTORS IN PROTECTIVE HOST RESPONSES TO NEUROTROPIC VIRUSES
Title
INVESTIGATING THE ROLE OF NEWLY DESCRIBED CYTOSOLIC PATTERN RECOGNITION RECEPTORS IN PROTECTIVE HOST RESPONSES TO NEUROTROPIC VIRUSES
Author
Crill, Emma
Date Created
2014
Subjects--Topical
Immunology, Virology
Description
The importance of the effector functions performed by glial cells, the resident cells of the CNS possessing immune functions, in abrogating potentially fatal neurotropic viral infections have only recently begun to gain appreciation. These effecto...
Intracellular pattern recognition receptors underlie inflammatory responses of glial cells to central nervous system pathogens
Title
Intracellular pattern recognition receptors underlie inflammatory responses of glial cells to central nervous system pathogens
Author
Sterka, David
Date Created
2009
Subjects--Topical
Cytology
Description
There is growing appreciation that the resident glial cells of the CNS, in particular microglia and astrocytes, are important participants in the generation of inflammation during brain infection. However, the mechanisms by which these cell types ...
THE ROLE OF MUC1 IN REGULATION AND PROGRESSION OF CANCER
Title
THE ROLE OF MUC1 IN REGULATION AND PROGRESSION OF CANCER
Author
Sahraeimanouchehrabadi, Mahnaz
Date Created
2011
Subjects--Topical
Immunology, Biology, Oncology
Description
MUC1 is a heavily glycosylated transmembrane glycoprotein which is overexpressed and aberrantly glycosylated in most human carcinomas. MUC1 contains a large tandem repeat, a short transmembrane, and a small cytoplasmic tail. Both tandem repeat and...