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Title: EFFECTS OF S-ADENOSYL-L-METHIONINE ON COLLAGEN EXPRESSION IN ACTIVATED HEPATIC STELLATE CELLS
Author: Thompson, Kyle
Date Created: 2009
Subjects--Topical: Biology, Cytology
Description: Liver fibrosis is defined as the excessive accumulation of extracellular matrix (ECM) components, which can disrupt the normal liver microcirculation and lead to injury. Unresolved, hepatic fibrosis can progress to cirrhosis, an end-state liver di...

Title: INTERLEUKIN-2 IN AQUEOUS AND LIPID ENVIRONMENTS: UNDERSTANDING MOLECULAR INTERACTIONS THAT IMPACT PHARMACEUTICAL FORMULATION DEVELOPMENT
Author: Vrikkis, Regina
Date Created: 2013
Subjects--Topical: Mechanical engineering, Biomedical engineering, Pharmacy--Research
Description: The continued development of pharmaceutical recombinant proteins as therapeutics necessitates a full understanding of the biomolecular interactions impacting structural and functional protein stability within different environments. Two such envir...

Title: Role of Nonmuscle Myosin II in Hepatic Stellate Cell Activation
Author: Moore, Cathy
Date Created: 2009
Subjects--Topical: Molecular biology
Description: The hepatic stellate cell (HSC) plays a pivotal role in the development of hepatic fibrosis. Regulation of liver microcirculation is a complex system where blood flow is under systemic and sinusoidal control. Upon a fibrogenic stimulus, quiescent ...