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Common Dietary and Environmental Compounds Promote a Leukemic Translocation in Hematopoietic Stem Cells and Differentiated Cells
Title
Common Dietary and Environmental Compounds Promote a Leukemic Translocation in Hematopoietic Stem Cells and Differentiated Cells
Author
Vestal, Carol
Date Created
2016
Subjects--Topical
Molecular biology, Biology, Genetics
Description
Maternal exposure to topoisomerase II (topoII) inhibitors that are biochemically similar to the chemotherapeutic drug etoposide may promote infant acute leukemia. Several studies have shown that common dietary bioflavonoids as well as benzene meta...
EVALUATING BIOFLAVONOID INDUCED DNA DOUBLE-STRAND BREAKS AND CHROMOSOMAL TRANSLOCATIONS
Title
EVALUATING BIOFLAVONOID INDUCED DNA DOUBLE-STRAND BREAKS AND CHROMOSOMAL TRANSLOCATIONS
Author
Goodenow, Donna
Date Created
2020
Subjects--Topical
Biology
Description
Dietary bioflavonoids are a class of chemical compounds found in soy, fruits, vegetables, tea, coffee, wine, and dietary supplements. They are separated into 12 different sub-classes based upon their structure, however only six are dietarily relev...
Examining the Contribution of the DNA Damage Response to Sepsis Survivor Myelosuppression
Title
Examining the Contribution of the DNA Damage Response to Sepsis Survivor Myelosuppression
Author
Huff, Laura
Date Created
2020
Subjects--Topical
Immunology, Biology, Pathology
Description
A large portion of patients who survive sepsis, a life-threatening hyperinflammatory response to infection resulting in organ dysfunction, experience a higher risk of mortality than non-septic patients. Innate immune cells of sepsis survivors exhi...
Genetic Structure and Gene Expression Profile of Plasmodium vivax in East Africa
Title
Genetic Structure and Gene Expression Profile of Plasmodium vivax in East Africa
Author
Kepple, Daniel
Date Created
2022
Subjects--Topical
Biology, Molecular biology, Cytology
Description
Plasmodium vivax malaria is a neglected tropical disease, despite being more geographically widespread than any other form of malaria. P. vivax was previously thought to be rare or absent in Africa because people of African descent often lack the ...
Inflammation, NLRP3 Inflammasomes, Macrophages and Breast Cancer Progression
Title
Inflammation, NLRP3 Inflammasomes, Macrophages and Breast Cancer Progression
Author
Holtzman , Katherine
Date Created
2021
Subjects--Topical
Biology, Immunology, Oncology
Description
One in 8 women will be diagnosed with breast cancer in their lifetime and while breast cancer mortality has declined since the 1980s, it remains the 2nd leading cause of cancer-related deaths among women. Standard of care is determined by anatomic...
Nonsegmented negative strand RNA viruses: viral RNA cap methylation and potential applications as an anticancer therapy
Title
Nonsegmented negative strand RNA viruses: viral RNA cap methylation and potential applications as an anticancer therapy
Author
Murphy, Andrea
Date Created
2012
Subjects--Topical
Virology, Biology
Description
The viruses of the order Mononegavirales include important human, animal, and plant pathogens and additionally, have great potential as vaccine, oncolytic and gene therapy vectors. This dissertation focuses on two prototypic Mononegavirales, vesic...
Pleiotropic effects on the transcriptome and genome of transgenic soybeans resulting from transgene integration and expression in seed tissue
Title
Pleiotropic effects on the transcriptome and genome of transgenic soybeans resulting from transgene integration and expression in seed tissue
Author
Lambirth, Kevin
Date Created
2015
Subjects--Topical
Molecular biology, Biology, Bioinformatics
Description
The seeds of the common soybean (Glycine max) produce and store large amounts of protein, making them an appealing bioreactor for producing valuable recombinant proteins at high levels. However, the effects of accumulating recombinant protein at h...
Polymer Mediated Delivery of Oligonucleotide and Trans Genes Toward More Efficient and Specific Therapies for Dystrophinopathies and Dystroglycanopathies
Title
Polymer Mediated Delivery of Oligonucleotide and Trans Genes Toward More Efficient and Specific Therapies for Dystrophinopathies and Dystroglycanopathies
Author
Tucker, Jason
Date Created
2014
Subjects--Topical
Molecular biology, Biology, Neurosciences
Description
Muscular dystrophies are genetic disorders caused by mutations in more than 30 genes, with no cure or effective treatment. Duchenne muscular dystrophy (DMD) is caused by frame-shift mutations in the dystrophin gene with little or no functional dys...
Understanding and overcoming limitations of vesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinoma
Title
Understanding and overcoming limitations of vesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinoma
Author
Hastie, Eric
Date Created
2014
Subjects--Topical
Virology, Biology
Description
Vesicular stomatitis virus (VSV) is a prototypic nonsegmented negative-strand RNA virus. Lack of preexisting immunity against VSV, inherent oncotropism, and genetic malleability make VSV a widely used platform for vaccine, oncolytic, and gene ther...