Search results | J. Murrey Atkins Library

Title: Quantifying the Binding Affinities of the PAI-H19Y Mutant of Sleeping Beauty Transposase to DNA
Author: Arango, Maria
Date Created: 2022
Subjects--Topical: Physics
Description: The Sleeping Beauty (SB) transposon system is the leading and only DNA transposon-based gene-delivery vehicle that has been adapted for human gene therapy. The SB system consists of a transposon DNA flanked by inverted terminal repeats (ITRs) and ...

Title: A VISUAL ANALYTICS APPROACH TO FEATURE DISCOVERY AND SUBSPACE EXPLORATION IN PROTEIN FLEXIBILITY MATRICES
Author: Barlowe, Scott
Date Created: 2011
Subjects--Topical: Computer science, Bioinformatics
Description: The vast amount of information generated by domain scientists makes the transitionfrom data to knowledge difficult and often impedes important discoveries. Forexample, the knowledge gained from protein flexibility data sets can speed advancesin ge...

Title: Moisture sorption behavior, stability, and protein formulation characteristics of a trehalose choline chloride eutectic composition
Author: Burgin, Tiffany
Date Created: 2017
Subjects--Topical: Mechanical engineering, Materials science, Biochemistry
Description: Protein based drugs and therapeutics are an important treatment for many life-threatening diseases but they can also be extremely expensive. The unique 3-dimensional structure of a protein is responsible for its function but also contributes to it...

Title: Asymptotic Normality of Higher Order Turing Formulae
Author: Chang, Jie
Date Created: 2022
Subjects--Topical: Mathematics
Description: Higher order Turing formulae, denoted as Tr for r ∈ Z+, are a powerful result allowing one to estimate the total probability associated with words from a random piece of writing, which have been observed exactly r times in a random sample. In part...

Title: A Detailed Description of Keldysh's Model of Photoionization
Author: Darden, Kenan
Date Created: 2023
Subjects--Topical: Physics, Optics, Quantum theory
Description: Leonid Keldysh’s 1965 paper "Ionization in the Field of a Strong Electromagnetic Wave" contains useful and simple-to-implement equations predicting the rate of photoionization in both atomic gasses and general crystalline solids. Crucially, his re...

Title: RED FLUORESCENCE IN BOVINE SERUM ALBUMIN – GOLD COMPLEXES
Author: Dixon, Jacob
Date Created: 2019
Subjects--Topical: Optics, Physics
Description: Bovine serum albumin (BSA)-gold (Au) complexes have been studied in great detail due to their unique red fluorescent (λem = 640 nm) properties, since being initially described by Xie et al. (J. Am. Chem. Soc. 2009, 131, 888-889) as a Au25 nanoclus...

Title: ALGORITHMS FOR STRUCTURE BASED-PREDICTION OF TRANSCRIPTION FACTOR BINDING SITES
Author: Farrel, Alvin
Date Created: 2016
Subjects--Topical: Computer science, Biology, Bioinformatics
Description: Transcription factors (TFs) regulate gene expression through binding to specific target DNA sites. Accurate annotation of transcription factor binding sites (TFBSs) at genome scale represents an essential step toward our understanding of gene regu...

Title: Light-assisted drying (LAD) for anhydrous preservation of biologics: processing sample volumes comparable to a therapeutic dose
Author: Furr, Daniel
Date Created: 2022
Subjects--Topical: Physics
Description: Protein-based products have been developed to treat a range of conditions and are used in vaccines and assays. A challenge in the development of these products is maintaining the protein in the folded state during processing and storage. The most ...

Title: REGULATION OF ACTOMYOSIN ATPASE
Author: Ge, Jinghua
Date Created: 2016
Subjects--Topical: Optics, Physics, Biophysics
Description: Myosin is a molecular motor that converts chemical energy to mechanical energy, thus generating force and movement in muscles and cells. Myosin interacts with two ligands, ATP (fuel) and actin filaments (motor’s tracks). Actomyosin interaction is ...

Title: Halogenated Tags for the Investigation of Enzyme Specificity
Author: Houde, Hailey
Date Created: 2023
Subjects--Topical: Biochemistry, Chemistry
Description: The bacterial enzyme undecaprenyl pyrophosphate synthase (UppS) is present in most prokaryotes and is needed for bacterial survival. UppS produces the essential lipid carrier, bactoprenyl monophosphate (BP). BP is critical for the structural integ...

Title: ESTIMATES FOR THE NUMBER OF EIGENVALUES OF NON-SELF-ADJOINT OPERATORS
Author: Hulko, Artem
Date Created: 2018
Subjects--Topical: Mathematics
Description: In this dissertation we find estimates for the total number of eigenvalues of non-self-adjoint operators. We consider five different operators, three of them discrete and two continuous. Discrete operators are as follows: Schrödinger operator defi...

Title: STUDIES ON CORRELATED MUTATIONS ALGORITHMS OF PROTEINS PROVIDING STRUCTURAL, SPATIAL, AND ALLOSTERY INFORMATION FROM MULTIPLE SEQUENCE ALIGNMENTS
Author: Kreth, Kyle
Date Created: 2013
Subjects--Topical: Bioinformatics
Description: Proteins provide innumerable cellular functions and benefits for all kingdoms in the domains of life. Advancements in the high throughput collection and analysis of proteins have led to ever-deeper understanding of biological pathways, evolution, ...

Title: The Application of Light-Assisted Drying to the Thermal Stabilization of Nucleic Acid Nanoparticles
Author: Lam, Phuong Anh
Date Created: 2021
Subjects--Topical: Physics
Description: Cold storage can be challenging and expensive for the transportation and storage of biologics. We are developing a new processing technique, light-assisted drying (LAD), to prepare biologics for anhydrous storage in a trehalose amorphous solid mat...

Title: STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE H19Y MUTATED PRIMARY DNA RECOGNITION SUBDOMAIN OF SLEEPING BEAUTY TRANSPOSASE
Author: Leighton, Gage
Date Created: 2017
Subjects--Topical: Physics, Chemistry, Physical and theoretical, Biophysics
Description: The Sleeping Beauty transposon system, consisting of the transposon DNA and the transposase enzyme, is a member of the Tc1/mariner family of DNA transposons. Although it is an important tool in genetic applications and has been adapted for human g...

Title: Design, Synthesis, Characterization and Simulation of Polyhedral Oligomeric Silsesquioxane Porphyrin Molecules to Fabricate Self-Assembled Nanoparticles and Their Use for Photodynamic Therapy
Author: Loman-Cortes, Paula
Date Created: 2021
Subjects--Topical: Nanoscience
Description: PAULA LOMAN-CORTES. Design, Synthesis, Characterization and Simulation of Polyhedral Oligomeric Silsesquioxane Porphyrin Molecules to Fabricate Self-Assembled Nanoparticles and Their Use for Photodynamic Therapy. (Under the direction of DR JUAN L ...

Title: Spatially Resolved Photoluminescence Lifetime Mapping in the Vicinity of Extended Defects in Semiconductors Using a Time Correlated Single Photon Counting System and Confocal Photoluminescence Microscopy
Author: Mode, Timothy
Date Created: 2016
Subjects--Topical: Optics, Physics
Description: Photoluminescence mapping and time resolved photoluminescence imaging have previously been used to study charge carrier dynamics in bulk semiconductors. Recently, our research group has used spatially resolved PL mapping to examine and model carri...

Title: Regulation of Myosin IIIa Motor/Kinase Activity
Author: Moore, Judy
Date Created: 2009
Subjects--Topical: Biochemistry, Neurosciences, Cytology
Description: Myosin IIIa, a motor protein that localizes to actin-rich regions of photoreceptors and to stereocilia of inner ear hair cells, is associated with the hearing process in vertebrates and with phototransduction for invertebrates. It contains a large...

Title: ELUCIDATING THE MOLECULAR BASIS OF INHIBITION OF ENZYMES ESSENTIAL FOR BATERIALVIRULENCE: THE ACTIVITY OF THREE GLYCOSYLTRANSFERASES AND A POTENTIAL DRUG TARGET, UNDECAPRENYL PYROPHOSPHATE SYNTHASE
Author: Okwei, Elleansar
Date Created: 2016
Subjects--Topical: Chemistry, Biology, Biochemistry
Description: The fight against bacterial infection is one of the most important branches of modern medicine. Due to the emergence of strains of antibiotic-resistant bacteria, researchers have been presented with complex challenges in an effort to combat these ...

Title: On Accelerating Road Vehicle Aerodynamics
Author: Peters, Brett
Date Created: 2018
Subjects--Topical: Mechanical engineering, Aerospace engineering, Fluid mechanics
Description: Road vehicle aerodynamics are primarily focused on developing and modeling performance at steady-state conditions, although this does not fully encompass the entire operating envelope. Considerable vehicle acceleration and deceleration occurs duri...

Title: Green Synthesis of Cellulose Graft Copolymers for Anion Exchange Water Purification
Author: Schmal, Stephen
Date Created: 2022
Subjects--Topical: Chemistry
Description: This thesis describes the synthesis and characterization of novel cellulose graft copolymers that are used for the purification of drinking water. These nanomaterials function as bottle-brush anion-exchange resins with repeating quaternary ammoniu...