Search results | J. Murrey Atkins Library

Title: A VISUAL ANALYTICS APPROACH TO FEATURE DISCOVERY AND SUBSPACE EXPLORATION IN PROTEIN FLEXIBILITY MATRICES
Author: Barlowe, Scott
Date Created: 2011
Subjects--Topical: Computer science, Bioinformatics
Description: The vast amount of information generated by domain scientists makes the transitionfrom data to knowledge difficult and often impedes important discoveries. Forexample, the knowledge gained from protein flexibility data sets can speed advancesin ge...

Title: ALGORITHMS FOR STRUCTURE BASED-PREDICTION OF TRANSCRIPTION FACTOR BINDING SITES
Author: Farrel, Alvin
Date Created: 2016
Subjects--Topical: Computer science, Biology, Bioinformatics
Description: Transcription factors (TFs) regulate gene expression through binding to specific target DNA sites. Accurate annotation of transcription factor binding sites (TFBSs) at genome scale represents an essential step toward our understanding of gene regu...

Title: Design, Synthesis, Characterization and Simulation of Polyhedral Oligomeric Silsesquioxane Porphyrin Molecules to Fabricate Self-Assembled Nanoparticles and Their Use for Photodynamic Therapy
Author: Loman-Cortes, Paula
Date Created: 2021
Subjects--Topical: Nanoscience
Description: PAULA LOMAN-CORTES. Design, Synthesis, Characterization and Simulation of Polyhedral Oligomeric Silsesquioxane Porphyrin Molecules to Fabricate Self-Assembled Nanoparticles and Their Use for Photodynamic Therapy. (Under the direction of DR JUAN L ...

Title: ELUCIDATING THE MOLECULAR BASIS OF INHIBITION OF ENZYMES ESSENTIAL FOR BATERIALVIRULENCE: THE ACTIVITY OF THREE GLYCOSYLTRANSFERASES AND A POTENTIAL DRUG TARGET, UNDECAPRENYL PYROPHOSPHATE SYNTHASE
Author: Okwei, Elleansar
Date Created: 2016
Subjects--Topical: Chemistry, Biology, Biochemistry
Description: The fight against bacterial infection is one of the most important branches of modern medicine. Due to the emergence of strains of antibiotic-resistant bacteria, researchers have been presented with complex challenges in an effort to combat these ...

Title: ESTIMATES FOR THE NUMBER OF EIGENVALUES OF NON-SELF-ADJOINT OPERATORS
Author: Hulko, Artem
Date Created: 2018
Subjects--Topical: Mathematics
Description: In this dissertation we find estimates for the total number of eigenvalues of non-self-adjoint operators. We consider five different operators, three of them discrete and two continuous. Discrete operators are as follows: Schrödinger operator defi...

Title: Implementation of Focusing Light through Highly Scattering Media via Sequential Algorithm Based Wavefront Shaping
Author: Williams, Desmond
Date Created: 2019
Subjects--Topical: Physics
Description: Propagation of light in communications, medicine, and science is hindered by the phenomenon of optical scattering. Methods to overcome this physical limitation have and continue to be researched. This work attempts to implement the method of wavef...

Title: Moisture sorption behavior, stability, and protein formulation characteristics of a trehalose choline chloride eutectic composition
Author: Burgin, Tiffany
Date Created: 2017
Subjects--Topical: Mechanical engineering, Materials science, Biochemistry
Description: Protein based drugs and therapeutics are an important treatment for many life-threatening diseases but they can also be extremely expensive. The unique 3-dimensional structure of a protein is responsible for its function but also contributes to it...

Title: On Accelerating Road Vehicle Aerodynamics
Author: Peters, Brett
Date Created: 2018
Subjects--Topical: Mechanical engineering, Aerospace engineering, Fluid mechanics
Description: Road vehicle aerodynamics are primarily focused on developing and modeling performance at steady-state conditions, although this does not fully encompass the entire operating envelope. Considerable vehicle acceleration and deceleration occurs duri...

Title: PROTEIN-PROTEIN INTERACTION OF PAI-H19Y MUTANT OF THE SLEEPING BEAUTY TRANSPOSASE
Author: Yan, Chenbo
Date Created: 2020
Subjects--Topical: Biophysics, DNA
Description: Due to the substantial interest in developing transposon technology for gene delivery and gene therapy, the Sleeping Beauty (SB) transposon system, the most active transposon in the vertebrate species, has been extensively studied. The SB transpos...

Title: RED FLUORESCENCE IN BOVINE SERUM ALBUMIN – GOLD COMPLEXES
Author: Dixon, Jacob
Date Created: 2019
Subjects--Topical: Optics, Physics
Description: Bovine serum albumin (BSA)-gold (Au) complexes have been studied in great detail due to their unique red fluorescent (λem = 640 nm) properties, since being initially described by Xie et al. (J. Am. Chem. Soc. 2009, 131, 888-889) as a Au25 nanoclus...

Title: REGULATION OF ACTOMYOSIN ATPASE
Author: Ge, Jinghua
Date Created: 2016
Subjects--Topical: Optics, Physics, Biophysics
Description: Myosin is a molecular motor that converts chemical energy to mechanical energy, thus generating force and movement in muscles and cells. Myosin interacts with two ligands, ATP (fuel) and actin filaments (motor’s tracks). Actomyosin interaction is ...

Title: RETENTION OF THE AMORPHOUS STATE OF TREHALOSE AT HIGH RELATIVE HUMIDITY USING ORGANIC SALT ADDITIVES: A MECHANISTIC UNDERSTANDING
Author: Ziaei, Shima
Date Created: 2018
Subjects--Topical: Materials science, Pharmacy--Research, Bioengineering
Description: The glassy or amorphous solid state of trehalose has been utilized in the food and pharmaceutical industry to immobilize and stabilize sensitive molecules and it is increasingly being explored for the preservation of biologics. Retention of the gl...

Title: Regulation of Myosin IIIa Motor/Kinase Activity
Author: Moore, Judy
Date Created: 2009
Subjects--Topical: Biochemistry, Neurosciences, Cytology
Description: Myosin IIIa, a motor protein that localizes to actin-rich regions of photoreceptors and to stereocilia of inner ear hair cells, is associated with the hearing process in vertebrates and with phototransduction for invertebrates. It contains a large...

Title: STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE H19Y MUTATED PRIMARY DNA RECOGNITION SUBDOMAIN OF SLEEPING BEAUTY TRANSPOSASE
Author: Leighton, Gage
Date Created: 2017
Subjects--Topical: Physics, Chemistry, Physical and theoretical, Biophysics
Description: The Sleeping Beauty transposon system, consisting of the transposon DNA and the transposase enzyme, is a member of the Tc1/mariner family of DNA transposons. Although it is an important tool in genetic applications and has been adapted for human g...

Title: STUDIES ON CORRELATED MUTATIONS ALGORITHMS OF PROTEINS PROVIDING STRUCTURAL, SPATIAL, AND ALLOSTERY INFORMATION FROM MULTIPLE SEQUENCE ALIGNMENTS
Author: Kreth, Kyle
Date Created: 2013
Subjects--Topical: Bioinformatics
Description: Proteins provide innumerable cellular functions and benefits for all kingdoms in the domains of life. Advancements in the high throughput collection and analysis of proteins have led to ever-deeper understanding of biological pathways, evolution, ...

Title: Spatially Resolved Photoluminescence Lifetime Mapping in the Vicinity of Extended Defects in Semiconductors Using a Time Correlated Single Photon Counting System and Confocal Photoluminescence Microscopy
Author: Mode, Timothy
Date Created: 2016
Subjects--Topical: Optics, Physics
Description: Photoluminescence mapping and time resolved photoluminescence imaging have previously been used to study charge carrier dynamics in bulk semiconductors. Recently, our research group has used spatially resolved PL mapping to examine and model carri...

Title: Spectroscopic study of optical confinement and transport effects in coupled microspheres and pillar cavities
Author: Yang, Seungmoo
Date Created: 2009
Subjects--Topical: Optics
Description: In this thesis we investigated the spatial and spectral mode profiles, and the optical transport properties of single and multiple coupled cavities. We performed numerical modeling of whispering gallery modes (WGMs) in such cavities in order to ex...

Title: The Application of Light-Assisted Drying to the Thermal Stabilization of Nucleic Acid Nanoparticles
Author: Lam, Phuong Anh
Date Created: 2021
Subjects--Topical: Physics
Description: Cold storage can be challenging and expensive for the transportation and storage of biologics. We are developing a new processing technique, light-assisted drying (LAD), to prepare biologics for anhydrous storage in a trehalose amorphous solid mat...