Search results | J. Murrey Atkins Library

Title: CHARACTERIZING NEXT-GENERATION SEQUENCING (NGS) PLATFORMS FOR MULTIPLEXED BIOSENSING AND APTAMER DISCOVERY: G-QUADRUPLEX APTAMERS AS A CASE STUDY
Author: Patil, Sushant
Date Created: 2016
Subjects--Topical: Molecular biology, Bioinformatics, Biochemistry
Description: Aptamers are single-stranded DNA or RNA molecules forming unique three dimensional structures that can bind to their targets (generally proteins or metabolites or other nucleic acids) with high specificity and affinity. Screening for aptamers requ...

Title: ENGINEERED WATER REPELLENCY FOR INFILTRATION CONTROL IN COAL FLY ASH
Author: Feyyisa, Jenberu
Date Created: 2017
Subjects--Topical: Civil engineering, Environmental engineering
Description: In 2014 approximately 47% of the 190 million short tons of coal combustion product (CCP) was recycled. As a construction material, coal fly ash (CFA) finds considerable use as a partial replacement for Portland cement, as structural fill, and as a...

Title: INTERLEUKIN-2 IN AQUEOUS AND LIPID ENVIRONMENTS: UNDERSTANDING MOLECULAR INTERACTIONS THAT IMPACT PHARMACEUTICAL FORMULATION DEVELOPMENT
Author: Vrikkis, Regina
Date Created: 2013
Subjects--Topical: Mechanical engineering, Biomedical engineering, Pharmacy--Research
Description: The continued development of pharmaceutical recombinant proteins as therapeutics necessitates a full understanding of the biomolecular interactions impacting structural and functional protein stability within different environments. Two such envir...

Title: INVESTIGATING THE ROLE OF NEWLY DESCRIBED CYTOSOLIC PATTERN RECOGNITION RECEPTORS IN PROTECTIVE HOST RESPONSES TO NEUROTROPIC VIRUSES
Author: Crill, Emma
Date Created: 2014
Subjects--Topical: Immunology, Virology
Description: The importance of the effector functions performed by glial cells, the resident cells of the CNS possessing immune functions, in abrogating potentially fatal neurotropic viral infections have only recently begun to gain appreciation. These effecto...

Title: Intracellular pattern recognition receptors underlie inflammatory responses of glial cells to central nervous system pathogens
Author: Sterka, David
Date Created: 2009
Subjects--Topical: Cytology
Description: There is growing appreciation that the resident glial cells of the CNS, in particular microglia and astrocytes, are important participants in the generation of inflammation during brain infection. However, the mechanisms by which these cell types ...

Title: Long-term study of changes in microbiota in a Cystic Fibrosis patient
Author: Stokell, Joshua
Date Created: 2013
Subjects--Topical: Biology, Microbiology
Description: Application of culture-independent techniques have revealed the presence of more types of bacteria than were previously thought, which led to the current description of Cystic Fibrosis (CF) being a polymicrobial disease. We know this polymicrobial...

Title: MICRO- TO MACROSCALE MODELING OF DRINKING WATER TREATMENT AND DISTRIBUTION
Author: Polaczyk, Amy
Date Created: 2010
Subjects--Topical: Environmental engineering, Environmental sciences
Description: Models are valuable tools that can provide quantitative insight into a process or system, but must to be kept simple to remain meaningful. In this dissertation, three separate drinking water research projects were completed using numerical modelin...

Title: MUC1 MEDIATED SIGNALING IN PANCREATIC DUCTAL ADENOCARCINOMA
Author: Grover, Priyanka
Date Created: 2019
Subjects--Topical: Biology
Description: In 2019, Pancreatic Cancer (PC) is the 3rd leading cause of cancer-related deaths in the USA with 94% dying within 5 years of diagnosis. 90% of PC is Pancreatic Ductal Adenocarcinoma (PDA), of which >80% overexpress a hypo-glycosylated form the me...

Title: NOVEL ROLES OF MICRORNAS IN HEPATITIS C
Author: Sendi, Hossein
Date Created: 2013
Subjects--Topical: Virology, Biology
Description: Approximately, 170 million people are infected by hepatitis C virus (HCV) worldwide, and of these, nearly 85% will develop chronic hepatitis C (CHC). Despite finding new anti-viral treatment that increase response rate from 45 % to 65-70 %, invest...

Title: Newly described cytosolic pattern recognition receptors mediate inflammatory glial responses to neurotropic viruses
Author: Furr, Samantha
Date Created: 2012
Subjects--Topical: Immunology, Biology
Description: The rapid onset of potentially lethal neuroinflammation is a defining feature of viral encephalitis. Glial cells are ideally positioned to respond to invading pathogens of the central nervous system (CNS) and produce key inflammatory mediators fol...

Title: RECIPROCAL REGULATION OF MYC AND MICRORNA MIR-308 DURING DROSOPHILA EMBRYOGENESIS
Author: Daneshvar, Kaveh
Date Created: 2012
Subjects--Topical: Molecular biology, Biology, Genetics
Description: Myc is a conserved transcription factor with a role in the regulation of genes that are involved in growth and development. The abundance of Myc protein in the cells must be exquisitely controlled to avoid growth abnormalities caused by too much o...

Title: ROLE OF THE NOVEL DNA SENSORS cGAS, IFI16, AND ZBP1, DURING VIRAL INFECTIONS IN GLIA
Author: Jeffries, Austin
Date Created: 2020
Subjects--Topical: Immunology, Virology, Neurosciences
Description: Viral central nervous system (CNS) infections can lead to life threatening encephalitis and long-term neurological deficits in survivors. Resident CNS cell types, such as astrocytes and microglia, are known to produce key inflammatory and antivira...

Title: Role of Intramolecular Electrostatic Interactions on the Kinetics of Human Cardiac Myosin β-Isoform
Author: Gargey, Akhil
Date Created: 2021
Subjects--Topical: Molecular biology, Biochemistry, Biophysics
Description: Human cardiac myosin has two isoforms, α and β, sharing significant sequence similarity, but different in kinetics. Small differences in the sequence are responsible for distinct local inter-residue interactions within α and β isoforms, leading to...

Title: Role of Intramolecular Electrostatic Interactions on the Kinetics of Human Cardiac Myosin β-Isoform
Author: Gargey, Akhil
Date Created: 2021
Subjects--Topical: Biophysics, Biochemistry, Molecular biology
Description: Human cardiac myosin has two isoforms, α and β, sharing significant sequence similarity, but different in kinetics. Small differences in the sequence are responsible for distinct local inter-residue interactions within α and β isoforms, leading to...

Title: SYNTHESIS AND CHARACTERIZATION OF A NOVEL SENSOR FOR NITROAROMATIC MOLECULES
Author: Nesmelov, Andrei
Date Created: 2019
Subjects--Topical: Chemistry, Organic, Chemistry, Polymers
Description: New conjugated spirosilabifluorene networks have been synthesized and characterized. They exhibit high surface areas, negligible solubility, broad chemical stability, and bright fluorescence. The materials have been analyzed as potential sensors f...

Title: THE DEVELOPMENT OF NOVEL THERAPEUTICS IN PANCREATIC AND BREAST CANCERS: POTENTIAL ROLE OF MUC1
Author: Besmer, Dahlia
Date Created: 2013
Subjects--Topical: Biology
Description: Pancreatic ductal adenocarcinoma (PDA) is the 4th leading cause of cancer-related deaths in the US, and breast cancer (BC) contributes to ~40,000 deaths annually. The development of novel therapeutic agents for improving patient outcome is of para...

Title: THE ROLE OF MUC1 IN REGULATION AND PROGRESSION OF CANCER
Author: Sahraeimanouchehrabadi, Mahnaz
Date Created: 2011
Subjects--Topical: Immunology, Biology, Oncology
Description: MUC1 is a heavily glycosylated transmembrane glycoprotein which is overexpressed and aberrantly glycosylated in most human carcinomas. MUC1 contains a large tandem repeat, a short transmembrane, and a small cytoplasmic tail. Both tandem repeat and...

Title: TRANSCRIPTIONAL REGULATION OF GENES ASSOCIATED WITH DRUG RESISTANCE AND GROWTH OF PANCREATIC CANCER CELLS BY MUCIN 1
Author: Nath, Sritama
Date Created: 2013
Subjects--Topical: Molecular biology, Cytology, Oncology
Description: Pancreatic ductal adenocarcinoma (PDA) is the 4th leading cause of cancer-related deaths in the US. An understanding of the molecular pathogenesis of PDA is of utmost importance to be able to improve the current or design new targeted therapies fo...