Search results | J. Murrey Atkins Library

Title: Pleiotropic effects on the transcriptome and genome of transgenic soybeans resulting from transgene integration and expression in seed tissue
Author: Lambirth, Kevin
Date Created: 2015
Subjects--Topical: Molecular biology, Biology, Bioinformatics
Description: The seeds of the common soybean (Glycine max) produce and store large amounts of protein, making them an appealing bioreactor for producing valuable recombinant proteins at high levels. However, the effects of accumulating recombinant protein at h...

Title: ELUCIDATING FUNCTIONAL MECHANISMS IN PROTEINS USING THE DISTANCE CONSTRAINT MODEL
Author: Singer, Christopher
Date Created: 2019
Subjects--Topical: Bioinformatics, Biophysics, Physics
Description: Protein thermodynamics has been shown to be insightful and illuminating to the functional mechanisms behind biological function. By characterizing proteins and protein families according to their enthalpy and entropy we can make inferences to the ...

Title: Hydrogen Sulfide Modulates Hepatic Oxygen Availability and Microcirculation during Sepsis
Author: Norris, Eric
Date Created: 2012
Subjects--Topical: Biology, Physiology
Description: A mismatch between O_{2_{supply and demand leads to the development of tissue hypoxia which contributes to hepatic dysfunction and injury during sepsis. Previously, we reported that hepatic microcirculatory failure is a major contributor to hypoxia a...}}

Title: INVESTIGATING THE ECOLOGICAL, PATHOGENIC, AND DORMANT LIFESTYLES OF THE ESTUARINE BACTERIUM, VIBRIO VULNIFICUS
Author: Williams, Tiffany
Date Created: 2015
Subjects--Topical: Microbiology, Bioinformatics
Description: Vibrio vulnificus is ubiquitous in estuarine and coastal waters worldwide and associates naturally with a variety of aquatic organisms. Notably, it is a highly invasive human pathogen capable of causing septicemia and multi-organ failure in person...

Title: DATA ANALYSIS WORKFLOW FOR GAS CHROMATOGRAPHY MASS SPECTROMETRY-BASED METABOLOMICS STUDIES
Author: Ni, Yan
Date Created: 2014
Subjects--Topical: Bioinformatics
Description: Metabolomics has emerged as an integral part of systems biology research that attempts to comprehensively study low molecular weight organic and inorganic metabolites under certain conditions within a biological system. Technological advances in t...

Title: Emerging Challenges in Landfill Leachate Quality and Ability of Fungal Bioreactors to Address Them
Author: Rezaei Adaryani, Amirhossein
Date Created: 2021
Subjects--Topical: Environmental engineering
Description: Landfill sites, that are the ultimate depository of solid waste stream in most societies, have the potential to generate leachate containing a complex mixture of contaminants of emerging concern (CECs) such as pharmaceutical compounds, plasticizer...

Title: Common Dietary and Environmental Compounds Promote a Leukemic Translocation in Hematopoietic Stem Cells and Differentiated Cells
Author: Vestal, Carol
Date Created: 2016
Subjects--Topical: Molecular biology, Biology, Genetics
Description: Maternal exposure to topoisomerase II (topoII) inhibitors that are biochemically similar to the chemotherapeutic drug etoposide may promote infant acute leukemia. Several studies have shown that common dietary bioflavonoids as well as benzene meta...

Title: New Algorithms for Protein Structure Analysis: From Nonparametric Density Estimation to Characterization of Molecular Volume Spatial Distributions
Author: Farmer, Jenny
Date Created: 2018
Subjects--Topical: Bioinformatics, Biophysics, Physics
Description: The Flexibility and Stability Test (FAST) is a C++ class library designed in the early 2000’s to execute free energy decomposition and reconstitution operations applied to protein structures. The library has been substantially expanded to include ...

Title: Nutritive Knowledge Based Discovery: Enhancing Precision Nutrition Hypothesis Generation
Author: Trautman, Aaron
Date Created: 2022
Subjects--Topical: Bioinformatics, Nutrition, Information science
Description: Diet-related diseases like obesity and type-2 diabetes are on the rise. Precision nutrition, a way to tailor dietary requirements for each individual, is heralded as a solution to these problems. However, nutritional research is held within sparse...

Title: The effect of structure in short regions of DNA on measurements on short-oligonucleotide microarray and Ion Torrent PGM sequencing platforms
Author: Khoshnevis, Saeed
Date Created: 2013
Subjects--Topical: Bioinformatics
Description: Single-stranded DNA in solution has been studied by biophysicists for many years, as complex structures, both stable and dynamic, form under normal experimental conditions. Stable intra-strand formations affect enzymatic technical processes such a...

Title: Regulation of Myosin IIIa Motor/Kinase Activity
Author: Moore, Judy
Date Created: 2009
Subjects--Topical: Biochemistry, Neurosciences, Cytology
Description: Myosin IIIa, a motor protein that localizes to actin-rich regions of photoreceptors and to stereocilia of inner ear hair cells, is associated with the hearing process in vertebrates and with phototransduction for invertebrates. It contains a large...

Title: The Microbiota Multiverse: From Gut to Brain and Beyond
Author: Brown, Matthew
Date Created: 2019
Subjects--Topical: Microbiology, Bioinformatics
Description: This work explores the microbiomes of diverse biological contexts with various stakeholders and collaborators. It consists of six objectives: the first two relate to interaction between the gut microbiome and host health, the second two investigat...

Title: Systematic Analysis of Antibiotic Resistance Genes (ARGs) in Water and Environmental System
Author: Park, Sol
Date Created: 2021
Subjects--Topical: Environmental engineering, Bioinformatics, Water resources development--Management
Description: The global research community is aware of the prevalence and ubiquity of antibiotic resistant genes (ARGs) which is increasing over time due to human activities (Allen et al. 2010; Baquero, Martínez, and Cantón 2008; Bergeron et al. 2016; Di Cesar...

Title: Microbial Mutations - Accumulation in Microfluidics and Collateral Sensitivity
Author: Turner, Nathan
Date Created: 2023
Subjects--Topical: Bioinformatics
Description: Mutations are a primary source of genetic variation and a major driving force in evolution by influencing survivability (fitness), genetic disease, and the development of complex traits such as antibiotic resistance. However, studying the mutation...

Title: The influence of wastewater treatment on community dynamics among antibiotic-resistant bacteria during treatment, stream release, and biosolids land application.
Author: Sorgen, Alicia
Date Created: 2020
Subjects--Topical: Microbiology, Bioinformatics, Ecology
Description: Wastewater treatment plants (WWTP) are a key link between anthropogenic activity and the environment, facilitating the development and horizontal transfer of antibiotic resistance among populations of commensal environmental microorganisms and cli...

Title: INVESTIGATING THE GENETIC BASIS OF GENE EXPRESSION USING EQTL TECHNIQUES
Author: Quitadamo, Andrew
Date Created: 2018
Subjects--Topical: Bioinformatics
Description: With advances in genome sequencing technology, datasets with large sample sizes can be generated relatively quickly and cheaply, especially compared to the past decade or so. We can utilize this data to analyze the associations between genetic var...

Title: Investigation and Analysis of Context Dependent Mutation Rates Contribution to Synonymous Mutation Codon Usage via Development of CDMAP.
Author: Patton, David
Date Created: 2022
Subjects--Topical: Bioinformatics, Molecular biology, Biometry
Description: Mutations play a pivotal role as a driver of genome evolution in organisms across the tree of life. However, site-specific mutation rates appear to have a non-uniform mutation rate and vary across the genome. Currently, site-specific variation has...

Title: Assessment of Methods and Environmental Influence on the Nematostella Vectensis Microbiome
Author: Krueger, Quinton
Date Created: 2022
Subjects--Topical: Microbiology, Bioinformatics
Description: Cnidarians are a diverse clade of marine invertebrates that inhabit a variety of environments. The conditions of these habitats are becoming more extreme with the progression of time. These organisms associate with bacteria, which are composed of ...

Title: UV-Based Advanced Oxidation Processes and Nanoscale Antimicrobials for Antibiotic Resistance Mitigation
Author: Sorinolu, Adeola
Date Created: 2022
Subjects--Topical: Environmental engineering, Nanoscience, Microbiology
Description: Antibiotic resistance (AR) is an ongoing pandemic that is unnoticed by many. AR is a global public health issue that challenges therapeutic potential against pathogens of humans and animals. Predictably, the environment has been implicated in the ...

Title: On Whole Genome Classifier Perforamnce in Relation to 16S Classifiers
Author: Johnson, James
Date Created: 2022
Subjects--Topical: Bioinformatics
Description: There is little consensus in the literature as to which approach for classification of Whole Genome Shotgun (WGS) sequences is most accurate unlike 16S classifiers that have had more time to mature. In this dissertation, two of the most popular cl...