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ALGORITHMS FOR STRUCTURE BASED-PREDICTION OF TRANSCRIPTION FACTOR BINDING SITES
Title
ALGORITHMS FOR STRUCTURE BASED-PREDICTION OF TRANSCRIPTION FACTOR BINDING SITES
Author
Farrel, Alvin
Date Created
2016
Subjects--Topical
Computer science, Biology, Bioinformatics
Description
Transcription factors (TFs) regulate gene expression through binding to specific target DNA sites. Accurate annotation of transcription factor binding sites (TFBSs) at genome scale represents an essential step toward our understanding of gene regu...
Comparative analysis of Nitrosococcus genomes; isolation, physiological and genomic characterization of the new ammonia-oxidizing species Nitrosococcus wardiae, strain D1FHST; and molecular studies towards a better understanding of ammonia-dependent chemo
Title
Comparative analysis of Nitrosococcus genomes; isolation, physiological and genomic characterization of the new ammonia-oxidizing species Nitrosococcus wardiae, strain D1FHST; and molecular studies towards a better understanding of ammonia-dependent chemolithotrophy
Author
Wang, Lin
Date Created
2016
Subjects--Topical
Molecular biology, Biology, Genetics
Description
Obligate aerobic chemolithoautotrophic ammonia-oxidzing bacteria (AOB) derive energy and reductant needed for growth solely from the oxidation of ammonia to nitrite thereby facilitating the process of nitritation. A strain of an ammonia-oxidizing ...
IDENTIFICATION OF EPITHELIAL OVARIAN TUMOR SPECIFIC APTAMERS THAT BIND AND INTERNALIZE INTO TARGET CELLS
Title
IDENTIFICATION OF EPITHELIAL OVARIAN TUMOR SPECIFIC APTAMERS THAT BIND AND INTERNALIZE INTO TARGET CELLS
Author
Benedetto, Gregory
Date Created
2015
Subjects--Topical
Chemistry, Biology
Description
New clinical tools that aid in the early diagnosis of ovarian malignancies will significantly help reduce mortality and improve current long-term survival rates. The objective of the work presented here was to identify ovarian tumor specific singl...
Long-term study of changes in microbiota in a Cystic Fibrosis patient
Title
Long-term study of changes in microbiota in a Cystic Fibrosis patient
Author
Stokell, Joshua
Date Created
2013
Subjects--Topical
Biology, Microbiology
Description
Application of culture-independent techniques have revealed the presence of more types of bacteria than were previously thought, which led to the current description of Cystic Fibrosis (CF) being a polymicrobial disease. We know this polymicrobial...
RECIPROCAL REGULATION OF MYC AND MICRORNA MIR-308 DURING DROSOPHILA EMBRYOGENESIS
Title
RECIPROCAL REGULATION OF MYC AND MICRORNA MIR-308 DURING DROSOPHILA EMBRYOGENESIS
Author
Daneshvar, Kaveh
Date Created
2012
Subjects--Topical
Molecular biology, Biology, Genetics
Description
Myc is a conserved transcription factor with a role in the regulation of genes that are involved in growth and development. The abundance of Myc protein in the cells must be exquisitely controlled to avoid growth abnormalities caused by too much o...
UNDERSTANDING BIAS IN NEXT-GENERATION SEQUENCING TECHNOLOGIES AND ANALYSES
Title
UNDERSTANDING BIAS IN NEXT-GENERATION SEQUENCING TECHNOLOGIES AND ANALYSES
Author
Price, Adam
Date Created
2017
Subjects--Topical
Biology, Bioinformatics, Biophysics
Description
The problem of bias resulting from biological and technological sources is one that must be consistently reexamined alongside the development of new technologies and methods of analysis. This dissertation addresses the complexities of bias identif...