Search results
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Title
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DE NOVO PREDICTION OF CIS-REGULATORY MODULES IN EUKARYOTIC ORGANISMS
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Author
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Niu, Meng
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Date Created
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2014
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Subjects--Topical
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Bioinformatics
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Description
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Gene regulation networks (GRNs) are the bases for virtually all biological processes. To gain a global understanding of GRNs encoded in a genome, we first need to identify in all the cis-regulatory elements (CREs) recognized by transcription facto...
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Title
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Development of Structural Informatics Method For Binding Peptides
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Author
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Patterson, John
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Date Created
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2023
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Subjects--Topical
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Bioinformatics
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Description
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In the continuous pursuit of advanced therapeutics, the field of bioinformatics hasinnovated tools that allow unprecedented control over the proteome, profoundly shaping our understanding and manipulation of biological domains. Computational appro...
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Title
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ESSENTIAL DYNAMICS OF PROTEINS USING GEOMETRICAL SIMULATIONS AND SUBSPACE ANALYSIS
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Author
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David, Charles
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Date Created
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2012
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Subjects--Topical
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Physics, Bioinformatics, Biophysics
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Description
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Essential dynamics is the application of principal component analysis to a dynamic trajectory derived from a simulation protocol in order to extract biologically relevant information contained in the high dimensional data. In this work, we apply t...
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Title
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Long-term study of changes in microbiota in a Cystic Fibrosis patient
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Author
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Stokell, Joshua
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Date Created
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2013
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Subjects--Topical
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Biology, Microbiology
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Description
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Application of culture-independent techniques have revealed the presence of more types of bacteria than were previously thought, which led to the current description of Cystic Fibrosis (CF) being a polymicrobial disease. We know this polymicrobial...
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Title
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Microarray tools and analysis methods to better characterize biological networks
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Author
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Overall, Christopher
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Date Created
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2012
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Subjects--Topical
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Bioinformatics
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Description
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To accurately model a biological system (e.g. cell), we first need to characterize each of its distinct networks. While omics data has given us unprecedented insight into the structure and dynamics of these networks, the associated analysis routin...
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Title
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Neural Network and Random Forest Based Eukaryotic Gene Prediction Methods
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Author
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Baker, Lonnie
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Date Created
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2023
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Subjects--Topical
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Bioinformatics
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Description
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Gene prediction, a fundamental task in genomics, plays a pivotal role in decipheringthe functional elements of genomes. However, accurate gene prediction remains a challenging endeavor, especially when dealing with non-model organisms that often l...
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Title
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RECIPROCAL REGULATION OF MYC AND MICRORNA MIR-308 DURING DROSOPHILA EMBRYOGENESIS
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Author
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Daneshvar, Kaveh
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Date Created
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2012
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Subjects--Topical
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Molecular biology, Biology, Genetics
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Description
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Myc is a conserved transcription factor with a role in the regulation of genes that are involved in growth and development. The abundance of Myc protein in the cells must be exquisitely controlled to avoid growth abnormalities caused by too much o...
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Title
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THE EFFECT OF TARGET SECONDARY STRUCTURE ON MICROARRAY DATA QUALITY
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Author
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Ratushna, Vladyslava
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Date Created
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2010
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Subjects--Topical
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Bioinformatics, Biophysics
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Description
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DNA microarrays have become an invaluable high throughput biotechnology method, which allows a parallel investigation of thousands of cellular events in a single experiment. The principle behind the technology is very simple: fluorescently labeled...
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Title
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UNDERSTANDING BIAS IN NEXT-GENERATION SEQUENCING TECHNOLOGIES AND ANALYSES
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Author
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Price, Adam
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Date Created
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2017
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Subjects--Topical
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Biology, Bioinformatics, Biophysics
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Description
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The problem of bias resulting from biological and technological sources is one that must be consistently reexamined alongside the development of new technologies and methods of analysis. This dissertation addresses the complexities of bias identif...
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Title
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UNDERSTANDING GENOME-WIDE GENE REGULATION IN PROKARYOTES USING OMICS DATA
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Author
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Seyedi Tabari, Seyed Ehsan
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Date Created
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2016
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Subjects--Topical
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Bioinformatics, Information science, Biometry
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Description
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Gene annotation is a critical step for understanding functions of genomes and host organisms. However, accurately annotating thousands of sequenced genomes can be a challenging task. Further, although gene transcriptional regulation is crucial for...
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Title
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Understanding gene transcriptional regulation at single cell resolution
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Author
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Xu, Chen
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Date Created
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2015
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Subjects--Topical
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Bioinformatics
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Description
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The recent advance of single-cell technologies has provided an unprecedented opportunity to bring new insights into many complex biological phenomena, such as the regulation of cell differentiation in a multi-cellular organism and cell-to-cell var...