Search results | J. Murrey Atkins Library

Title: Understanding and overcoming limitations of vesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinoma
Author: Hastie, Eric
Date Created: 2014
Subjects--Topical: Virology, Biology
Description: Vesicular stomatitis virus (VSV) is a prototypic nonsegmented negative-strand RNA virus. Lack of preexisting immunity against VSV, inherent oncotropism, and genetic malleability make VSV a widely used platform for vaccine, oncolytic, and gene ther...

Title: Understanding The Role of Pancreatic Ductal Adenocarcinoma Chemoresistance and Intertumoral Heterogeneity on Vesicular Stomatitis Virus-based Oncolytic Therapy
Author: Goad, Dakota
Date Created: 2023
Subjects--Topical: Biology, Virology, Biomedical engineering
Description: Viruses are obligate intracellular parasites that are now being increasingly harnessed as therapeutics for human diseases. Investigating different cellular factors and processes that affect viral infection allows us to improve the efficacy of viru...

Title: The Local Dynamics of Basement Membrane Breaching During Cancer Cell Invasion
Author: Nazari, Shayan
Date Created: 2022
Subjects--Topical: Biology
Description: Solid tumor metastasis is the leading cause of cancer-related mortality. Cancer invasion through the confining basement membrane (BM) is the initial step in tumor dissemination and metastasis, and it represents a key diagnostic feature of cancer. ...

Title: The Determination of Temperature-dependent CPA Diffusion Properties in Feline Testicular Tissue
Author: Kirkland, Kaitlyn
Date Created: 2022
Subjects--Topical: Biomedical engineering
Description: Fertility preservation would benefit young males who must undergo treatments that can result in sterilization, such as radiation treatments for cancer. This can be achieved by removing some testicular tissue before treatment and putting it into fr...

Title: TRANSCRIPTIONAL REGULATION OF GENES ASSOCIATED WITH DRUG RESISTANCE AND GROWTH OF PANCREATIC CANCER CELLS BY MUCIN 1
Author: Nath, Sritama
Date Created: 2013
Subjects--Topical: Molecular biology, Cytology, Oncology
Description: Pancreatic ductal adenocarcinoma (PDA) is the 4th leading cause of cancer-related deaths in the US. An understanding of the molecular pathogenesis of PDA is of utmost importance to be able to improve the current or design new targeted therapies fo...

Title: THE ROLE OF XRCC1 AND POLYMERASE BETA IN GENOME INTEGRITY IN XENOPUS EGG EXTRACTS
Author: Cupello, Steven
Date Created: 2019
Subjects--Topical: Molecular biology, Biology, Cytology
Description: Cells of organisms are constantly exposed to genomic insults such as oxidative stress from endogenous sources or environmental agents. Oxidative stress induces oxidative DNA damage such as apurinic/apyrimidinic (AP) sites, single-strand breaks (SS...

Title: THE ROLE OF TRANSLESION SYNTHESIS POLYMERASES REV1 AND POL η IN DNA DAMAGE RESPONSE
Author: McLeod, Melissa
Date Created: 2016
Subjects--Topical: Molecular biology, Biology, Cytology
Description: Our cells endure continuous challenges from byproducts of endogenous metabolic processes as well as outside sources such as UV light and environmental polltants. The DNA Damage Response (DDR) helps organisms cope with damage and coordinate an appr...

Title: THE DEVELOPMENT OF NOVEL THERAPEUTICS IN PANCREATIC AND BREAST CANCERS: POTENTIAL ROLE OF MUC1
Author: Besmer, Dahlia
Date Created: 2013
Subjects--Topical: Biology
Description: Pancreatic ductal adenocarcinoma (PDA) is the 4th leading cause of cancer-related deaths in the US, and breast cancer (BC) contributes to ~40,000 deaths annually. The development of novel therapeutic agents for improving patient outcome is of para...

Title: SINGLE-STEP, REDUCED SHEAR, MICROFLUIDIC EXTRUSION OF BLOOD BRAIN BARRIER
Author: Wetzel, Isaac
Date Created: 2019
Subjects--Topical: Biomedical engineering
Description: Three-dimensional (3D) bioprinting of living structures with cell-laden biomaterials has been achieved in vitro, however, central nervous system tissues have been limited by the low viability printing of cerebral vessels, using conventional printi...

Title: SELECTIVE HEATING OF VASCULAR STRUCTURES TO CREATE CONTRAST IN MEDICAL MID-IR IMAGES
Author: Case, Jason
Date Created: 2015
Subjects--Topical: Optics, Diagnostic imaging
Description: The goal of this study is to develop an enhanced mid-IR imaging modality for mapping vascular structures. This imaging technique is intended for real-time use by medical professionals during surgical procedures such as tumor removal and vascular m...

Title: Role of Nonmuscle Myosin II in Hepatic Stellate Cell Activation
Author: Moore, Cathy
Date Created: 2009
Subjects--Topical: Molecular biology
Description: The hepatic stellate cell (HSC) plays a pivotal role in the development of hepatic fibrosis. Regulation of liver microcirculation is a complex system where blood flow is under systemic and sinusoidal control. Upon a fibrogenic stimulus, quiescent ...

Title: ROLE OF AQUAPORINS DURING HEPATOCELLULAR CARCINOMA INITIATION AND PROGRESSION
Author: Mattocks, Matthew
Date Created: 2010
Subjects--Topical: Molecular biology, Cytology, Oncology
Description: Aquaporins (AQPs) are ubiquitously expressed proteinaceous water channels involved in numerous physiological processes including bile production and apoptosis. Aquaporins 8 and 9 are expressed in hepatocytes, and are down regulated in a rat model ...

Title: RED FLUORESCENCE IN BOVINE SERUM ALBUMIN – GOLD COMPLEXES
Author: Dixon, Jacob
Date Created: 2019
Subjects--Topical: Optics, Physics
Description: Bovine serum albumin (BSA)-gold (Au) complexes have been studied in great detail due to their unique red fluorescent (λem = 640 nm) properties, since being initially described by Xie et al. (J. Am. Chem. Soc. 2009, 131, 888-889) as a Au25 nanoclus...

Title: MODELING CRASH RISK DUE TO TRAFFIC RULE VIOLATIONS FOR EDUCATION, ENFORCEMENT AND ENGINEERING COUNTERMEASURES
Author: Penmetsa, Praveena
Date Created: 2017
Subjects--Topical: Civil engineering, Transportation
Description: With 1.3 million deaths, motor vehicle crashes contributed to 2.2% of the total deaths in the world during 2012. Traffic rule violations are the major reason for the occurrence of crashes and fatalities world-wide. Education, enforcement and engin...

Title: Interaction between hydrogen sulfide and endothelin-1 in hepatic perfusion and mitochondrial dynamics in endotoxemia
Author: Pennington, Samantha
Date Created: 2018
Subjects--Topical: Physiology, Cytology
Description: A mismatch between oxygen supply and metabolic tissue demand leads to the development of hypoxia, which contributes to hepatic dysfunction and liver injury during sepsis. Recent evidence shows that hepatic H2S levels are increased during sepsis an...

Title: IDENTIFICATION OF EPITHELIAL OVARIAN TUMOR SPECIFIC APTAMERS THAT BIND AND INTERNALIZE INTO TARGET CELLS
Author: Benedetto, Gregory
Date Created: 2015
Subjects--Topical: Chemistry, Biology
Description: New clinical tools that aid in the early diagnosis of ovarian malignancies will significantly help reduce mortality and improve current long-term survival rates. The objective of the work presented here was to identify ovarian tumor specific singl...

Title: Hydrogen Sulfide Modulates Hepatic Oxygen Availability and Microcirculation during Sepsis
Author: Norris, Eric
Date Created: 2012
Subjects--Topical: Biology, Physiology
Description: A mismatch between O_{2_{supply and demand leads to the development of tissue hypoxia which contributes to hepatic dysfunction and injury during sepsis. Previously, we reported that hepatic microcirculatory failure is a major contributor to hypoxia a...}}

Title: GLYCOGEN ENHANCEMENT AUGMENTS OVERLOAD-INDUCED PROTEIN SYNTHESIS, GROWTH, AND MYOGENESIS IN AGED SKELETAL MUSCLE
Author: Lawrence, Marcus
Date Created: 2017
Subjects--Topical: Biology, Kinesiology, Physiology
Description: ABSTRACTMARCUS MICHAEL LAWRENCE. Glycogen Enhancement Augments Overload-Induced Protein Synthesis, Growth, and Myogenesis in Aged Skeletal Muscle. (Under the direction of DR. SCOTT E. GORDON)Age-related skeletal muscle (SkM) wasting is associated ...

Title: FUNCTIONAL NUCLEIC ACID NANOPARTICLES AND THEIR DELIVERY
Author: Ke, Weina
Date Created: 2020
Subjects--Topical: Biochemistry, Cytology
Description: Nucleic acid biopolymers are essential to all living organisms. The chemical makeup of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) consist of sequences of only four monomers. However, they transmit and express genetic information for va...

Title: Examining the Contribution of the DNA Damage Response to Sepsis Survivor Myelosuppression
Author: Huff, Laura
Date Created: 2020
Subjects--Topical: Immunology, Biology, Pathology
Description: A large portion of patients who survive sepsis, a life-threatening hyperinflammatory response to infection resulting in organ dysfunction, experience a higher risk of mortality than non-septic patients. Innate immune cells of sepsis survivors exhi...