Search results | J. Murrey Atkins Library

Title: Bioactive ceramic coating on orthopedic implants for enhanced bone tissue integration
Author: Aniket, .
Date Created: 2012
Subjects--Topical: Materials science, Nanoscience, Biomedical engineering
Description: Tissue integration between bone and orthopedic implant is essential for implant fixation and longevity. An immunological response leads to fibrous encapsulation of metallic implants leading to implant instability and failure. Bioactive ceramics ha...

Title: IDENTIFICATION OF EPITHELIAL OVARIAN TUMOR SPECIFIC APTAMERS THAT BIND AND INTERNALIZE INTO TARGET CELLS
Author: Benedetto, Gregory
Date Created: 2015
Subjects--Topical: Chemistry, Biology
Description: New clinical tools that aid in the early diagnosis of ovarian malignancies will significantly help reduce mortality and improve current long-term survival rates. The objective of the work presented here was to identify ovarian tumor specific singl...

Title: THE DEVELOPMENT OF NOVEL THERAPEUTICS IN PANCREATIC AND BREAST CANCERS: POTENTIAL ROLE OF MUC1
Author: Besmer, Dahlia
Date Created: 2013
Subjects--Topical: Biology
Description: Pancreatic ductal adenocarcinoma (PDA) is the 4th leading cause of cancer-related deaths in the US, and breast cancer (BC) contributes to ~40,000 deaths annually. The development of novel therapeutic agents for improving patient outcome is of para...

Title: Abrogating the oncogenic signaling associated with tumor MUC1 in Pancreatic Ductal Adenocarcinoma
Author: Bose, Mukulika
Date Created: 2022
Subjects--Topical: Molecular biology, Biochemistry, Oncology
Description: Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human cancers. The incidence rate of PDA nearly matches its mortality rate and the best treatment till date is surgical resection for which only 25\% are eligible. Tumor recurrence a...

Title: CORTICAL ACTIVITY OF THE SENSORIMOTOR SYSTEM IN PARTICIPANTS WITH CHRONIC ANKLE INSTABILITY
Author: Burcal, Christopher
Date Created: 2017
Subjects--Topical: Biology, Kinesiology, Neurosciences
Description: Patients with chronic ankle instability (CAI) exhibit a wide variety of sensorimotor deficits. These include impairments in feed-forward sensorimotor control (i.e. motor planning) as well as feed-back sensorimotor control, which pertains to refini...

Title: SELECTIVE HEATING OF VASCULAR STRUCTURES TO CREATE CONTRAST IN MEDICAL MID-IR IMAGES
Author: Case, Jason
Date Created: 2015
Subjects--Topical: Optics, Diagnostic imaging
Description: The goal of this study is to develop an enhanced mid-IR imaging modality for mapping vascular structures. This imaging technique is intended for real-time use by medical professionals during surgical procedures such as tumor removal and vascular m...

Title: Additive Manufacturing of 3D Printed SiC Composites: Strengthening and Densification through Surface Modification and Use of Mineral Binders
Author: Chandrasekaran, Sujithra
Date Created: 2023
Subjects--Topical: Engineering, Materials science, Mechanical engineering
Description: Manufacturing of dense SiC composites counts mainly on the thermal oxidation of the carbide into silica. The irregularity of the silica layer and its limited thickness weaken the bond between particles and diminish the good thermo-mechanical prope...

Title: THE ROLE OF XRCC1 AND POLYMERASE BETA IN GENOME INTEGRITY IN XENOPUS EGG EXTRACTS
Author: Cupello, Steven
Date Created: 2019
Subjects--Topical: Molecular biology, Biology, Cytology
Description: Cells of organisms are constantly exposed to genomic insults such as oxidative stress from endogenous sources or environmental agents. Oxidative stress induces oxidative DNA damage such as apurinic/apyrimidinic (AP) sites, single-strand breaks (SS...

Title: RED FLUORESCENCE IN BOVINE SERUM ALBUMIN – GOLD COMPLEXES
Author: Dixon, Jacob
Date Created: 2019
Subjects--Topical: Optics, Physics
Description: Bovine serum albumin (BSA)-gold (Au) complexes have been studied in great detail due to their unique red fluorescent (λem = 640 nm) properties, since being initially described by Xie et al. (J. Am. Chem. Soc. 2009, 131, 888-889) as a Au25 nanoclus...

Title: Understanding The Role of Pancreatic Ductal Adenocarcinoma Chemoresistance and Intertumoral Heterogeneity on Vesicular Stomatitis Virus-based Oncolytic Therapy
Author: Goad, Dakota
Date Created: 2023
Subjects--Topical: Biology, Virology, Biomedical engineering
Description: Viruses are obligate intracellular parasites that are now being increasingly harnessed as therapeutics for human diseases. Investigating different cellular factors and processes that affect viral infection allows us to improve the efficacy of viru...

Title: Development of injectable bioceramic drug delivery system for solid tumor treatment
Author: Haig, James
Date Created: 2017
Subjects--Topical: Materials science, Engineering, Biomedical engineering
Description: According to the national cancer institute "In 2016, an estimated 1,685,210 new cases of cancer will be diagnosed in the United States and 595,690 people will die from the disease" and "The number of people living beyond a cancer diagnosis reached...

Title: Understanding and overcoming limitations of vesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinoma
Author: Hastie, Eric
Date Created: 2014
Subjects--Topical: Virology, Biology
Description: Vesicular stomatitis virus (VSV) is a prototypic nonsegmented negative-strand RNA virus. Lack of preexisting immunity against VSV, inherent oncotropism, and genetic malleability make VSV a widely used platform for vaccine, oncolytic, and gene ther...

Title: Examining the Contribution of the DNA Damage Response to Sepsis Survivor Myelosuppression
Author: Huff, Laura
Date Created: 2020
Subjects--Topical: Immunology, Biology, Pathology
Description: A large portion of patients who survive sepsis, a life-threatening hyperinflammatory response to infection resulting in organ dysfunction, experience a higher risk of mortality than non-septic patients. Innate immune cells of sepsis survivors exhi...

Title: FUNCTIONAL NUCLEIC ACID NANOPARTICLES AND THEIR DELIVERY
Author: Ke, Weina
Date Created: 2020
Subjects--Topical: Biochemistry, Cytology
Description: Nucleic acid biopolymers are essential to all living organisms. The chemical makeup of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) consist of sequences of only four monomers. However, they transmit and express genetic information for va...

Title: The Determination of Temperature-dependent CPA Diffusion Properties in Feline Testicular Tissue
Author: Kirkland, Kaitlyn
Date Created: 2022
Subjects--Topical: Biomedical engineering
Description: Fertility preservation would benefit young males who must undergo treatments that can result in sterilization, such as radiation treatments for cancer. This can be achieved by removing some testicular tissue before treatment and putting it into fr...

Title: GLYCOGEN ENHANCEMENT AUGMENTS OVERLOAD-INDUCED PROTEIN SYNTHESIS, GROWTH, AND MYOGENESIS IN AGED SKELETAL MUSCLE
Author: Lawrence, Marcus
Date Created: 2017
Subjects--Topical: Biology, Kinesiology, Physiology
Description: ABSTRACTMARCUS MICHAEL LAWRENCE. Glycogen Enhancement Augments Overload-Induced Protein Synthesis, Growth, and Myogenesis in Aged Skeletal Muscle. (Under the direction of DR. SCOTT E. GORDON)Age-related skeletal muscle (SkM) wasting is associated ...

Title: ROLE OF AQUAPORINS DURING HEPATOCELLULAR CARCINOMA INITIATION AND PROGRESSION
Author: Mattocks, Matthew
Date Created: 2010
Subjects--Topical: Molecular biology, Cytology, Oncology
Description: Aquaporins (AQPs) are ubiquitously expressed proteinaceous water channels involved in numerous physiological processes including bile production and apoptosis. Aquaporins 8 and 9 are expressed in hepatocytes, and are down regulated in a rat model ...

Title: Enhanced Thermal Imaging a Novel Imaging Technique for Monitoring Re-Perfusion Post-Operatively
Author: McGinnis, Cobey
Date Created: 2023
Subjects--Topical: Optics, Biomedical engineering, Physics
Description: We are developing a real-time infrared imaging technique, Enhanced Thermal Imaging(ETI), that can detect blood vessels embedded in tissue and assess tissue perfusion. ETI is a combination of standard thermal imaging (8 - 10 μm) and selective heati...

Title: THE ROLE OF TRANSLESION SYNTHESIS POLYMERASES REV1 AND POL η IN DNA DAMAGE RESPONSE
Author: McLeod, Melissa
Date Created: 2016
Subjects--Topical: Molecular biology, Biology, Cytology
Description: Our cells endure continuous challenges from byproducts of endogenous metabolic processes as well as outside sources such as UV light and environmental polltants. The DNA Damage Response (DDR) helps organisms cope with damage and coordinate an appr...

Title: Role of Nonmuscle Myosin II in Hepatic Stellate Cell Activation
Author: Moore, Cathy
Date Created: 2009
Subjects--Topical: Molecular biology
Description: The hepatic stellate cell (HSC) plays a pivotal role in the development of hepatic fibrosis. Regulation of liver microcirculation is a complex system where blood flow is under systemic and sinusoidal control. Upon a fibrogenic stimulus, quiescent ...