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- Title
- A NOVEL ANTIBODY FOR THE DETECTION AND TREATMENT OF PANCREATIC DUCTAL ADENOCARCINOMA
- Author
- Wu, Shuta
- Date Created
- 2017
- Subjects--Topical
- Biology, Oncology
- Description
- Pancreatic ductal adenocarcinoma (PDA) remains the most aggressive cancer with a 5-year survival rate below 10%. Two of the major contributors to this dismal prognosis are late-stage diagnosis and limited treatment options. Common symptoms of PDA ...
- Title
- CHIMERIC ANTIGEN RECEPTOR (CAR) T CELL IMMUNOTHERAPY FOR MUCIN 1 (MUC1)-POSITIVE PANCREATIC DUCTAL ADENOCARCINOMA
- Author
- Yazdanifar, Mahboubeh
- Date Created
- 2019
- Subjects--Topical
- Biology
- Description
- Chimeric antigen receptor engineered (CAR) T cells have shown remarkable success in the treatment of hematologic cancers. However, this efficacy has yet to translate to treatment in solid tumors. Pancreatic ductal adenocarcinoma (PDA) is a fatal m...
- Title
- CORTICAL ACTIVITY OF THE SENSORIMOTOR SYSTEM IN PARTICIPANTS WITH CHRONIC ANKLE INSTABILITY
- Author
- Burcal, Christopher
- Date Created
- 2017
- Subjects--Topical
- Biology, Kinesiology, Neurosciences
- Description
- Patients with chronic ankle instability (CAI) exhibit a wide variety of sensorimotor deficits. These include impairments in feed-forward sensorimotor control (i.e. motor planning) as well as feed-back sensorimotor control, which pertains to refini...
- Title
- Common Dietary and Environmental Compounds Promote a Leukemic Translocation in Hematopoietic Stem Cells and Differentiated Cells
- Author
- Vestal, Carol
- Date Created
- 2016
- Subjects--Topical
- Molecular biology, Biology, Genetics
- Description
- Maternal exposure to topoisomerase II (topoII) inhibitors that are biochemically similar to the chemotherapeutic drug etoposide may promote infant acute leukemia. Several studies have shown that common dietary bioflavonoids as well as benzene meta...
- Title
- Dry Preservation of Germinal Vesicles: Development of a New Formulation to Preserve DNA Integrity Under Adverse Environmental Conditions
- Author
- Orozco Cabral, Joseph
- Date Created
- 2022
- Subjects--Topical
- Biology, Bioengineering
- Description
- Advances in the cryopreservation of genetic material has revolutionized human reproductive medicine and animal conservation efforts. Despite many successes, oocytes have been more challenging to cryopreserve than sperm. Their large size makes it d...
- Title
- EXPERIMENTAL EVOLUTION OF ONCOLYTIC VESICULAR STOMATITIS VIRUSES IN CANCER CELLS
- Author
- Seegers, Sara
- Date Created
- 2019
- Subjects--Topical
- Molecular biology, Virology, Biology
- Description
- Vesicular stomatitis virus (VSV) based oncolytic viruses are promising agents against various cancers. We have shown that pancreatic ductal adenocarcinoma (PDAC) cell lines exhibit great diversity in susceptibility and permissibility to VSV. Here,...
- Title
- Examining the Contribution of the DNA Damage Response to Sepsis Survivor Myelosuppression
- Author
- Huff, Laura
- Date Created
- 2020
- Subjects--Topical
- Immunology, Biology, Pathology
- Description
- A large portion of patients who survive sepsis, a life-threatening hyperinflammatory response to infection resulting in organ dysfunction, experience a higher risk of mortality than non-septic patients. Innate immune cells of sepsis survivors exhi...
- Title
- GLYCOGEN ENHANCEMENT AUGMENTS OVERLOAD-INDUCED PROTEIN SYNTHESIS, GROWTH, AND MYOGENESIS IN AGED SKELETAL MUSCLE
- Author
- Lawrence, Marcus
- Date Created
- 2017
- Subjects--Topical
- Biology, Kinesiology, Physiology
- Description
- ABSTRACTMARCUS MICHAEL LAWRENCE. Glycogen Enhancement Augments Overload-Induced Protein Synthesis, Growth, and Myogenesis in Aged Skeletal Muscle. (Under the direction of DR. SCOTT E. GORDON)Age-related skeletal muscle (SkM) wasting is associated ...
- Title
- Hydrogen Sulfide Modulates Hepatic Oxygen Availability and Microcirculation during Sepsis
- Author
- Norris, Eric
- Date Created
- 2012
- Subjects--Topical
- Biology, Physiology
- Description
- A mismatch between O2 supply and demand leads to the development of tissue hypoxia which contributes to hepatic dysfunction and injury during sepsis. Previously, we reported that hepatic microcirculatory failure is a major contributor to hypoxia a...
- Title
- IDENTIFICATION OF EPITHELIAL OVARIAN TUMOR SPECIFIC APTAMERS THAT BIND AND INTERNALIZE INTO TARGET CELLS
- Author
- Benedetto, Gregory
- Date Created
- 2015
- Subjects--Topical
- Chemistry, Biology
- Description
- New clinical tools that aid in the early diagnosis of ovarian malignancies will significantly help reduce mortality and improve current long-term survival rates. The objective of the work presented here was to identify ovarian tumor specific singl...
- Title
- THE DEVELOPMENT OF NOVEL THERAPEUTICS IN PANCREATIC AND BREAST CANCERS: POTENTIAL ROLE OF MUC1
- Author
- Besmer, Dahlia
- Date Created
- 2013
- Subjects--Topical
- Biology
- Description
- Pancreatic ductal adenocarcinoma (PDA) is the 4th leading cause of cancer-related deaths in the US, and breast cancer (BC) contributes to ~40,000 deaths annually. The development of novel therapeutic agents for improving patient outcome is of para...
- Title
- THE ROLE OF TRANSLESION SYNTHESIS POLYMERASES REV1 AND POL η IN DNA DAMAGE RESPONSE
- Author
- McLeod, Melissa
- Date Created
- 2016
- Subjects--Topical
- Molecular biology, Biology, Cytology
- Description
- Our cells endure continuous challenges from byproducts of endogenous metabolic processes as well as outside sources such as UV light and environmental polltants. The DNA Damage Response (DDR) helps organisms cope with damage and coordinate an appr...
- Title
- THE ROLE OF XRCC1 AND POLYMERASE BETA IN GENOME INTEGRITY IN XENOPUS EGG EXTRACTS
- Author
- Cupello, Steven
- Date Created
- 2019
- Subjects--Topical
- Molecular biology, Biology, Cytology
- Description
- Cells of organisms are constantly exposed to genomic insults such as oxidative stress from endogenous sources or environmental agents. Oxidative stress induces oxidative DNA damage such as apurinic/apyrimidinic (AP) sites, single-strand breaks (SS...
- Title
- The Local Dynamics of Basement Membrane Breaching During Cancer Cell Invasion
- Author
- Nazari, Shayan
- Date Created
- 2022
- Subjects--Topical
- Biology
- Description
- Solid tumor metastasis is the leading cause of cancer-related mortality. Cancer invasion through the confining basement membrane (BM) is the initial step in tumor dissemination and metastasis, and it represents a key diagnostic feature of cancer. ...
- Title
- Understanding The Role of Pancreatic Ductal Adenocarcinoma Chemoresistance and Intertumoral Heterogeneity on Vesicular Stomatitis Virus-based Oncolytic Therapy
- Author
- Goad, Dakota
- Date Created
- 2023
- Subjects--Topical
- Biology, Virology, Biomedical engineering
- Description
- Viruses are obligate intracellular parasites that are now being increasingly harnessed as therapeutics for human diseases. Investigating different cellular factors and processes that affect viral infection allows us to improve the efficacy of viru...
- Title
- Understanding and overcoming limitations of vesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinoma
- Author
- Hastie, Eric
- Date Created
- 2014
- Subjects--Topical
- Virology, Biology
- Description
- Vesicular stomatitis virus (VSV) is a prototypic nonsegmented negative-strand RNA virus. Lack of preexisting immunity against VSV, inherent oncotropism, and genetic malleability make VSV a widely used platform for vaccine, oncolytic, and gene ther...