Search results | J. Murrey Atkins Library

Title: A NOVEL ANTIBODY FOR THE DETECTION AND TREATMENT OF PANCREATIC DUCTAL ADENOCARCINOMA
Author: Wu, Shuta
Date Created: 2017
Subjects--Topical: Biology, Oncology
Description: Pancreatic ductal adenocarcinoma (PDA) remains the most aggressive cancer with a 5-year survival rate below 10%. Two of the major contributors to this dismal prognosis are late-stage diagnosis and limited treatment options. Common symptoms of PDA ...

Title: Bioactive ceramic coating on orthopedic implants for enhanced bone tissue integration
Author: Aniket, .
Date Created: 2012
Subjects--Topical: Materials science, Nanoscience, Biomedical engineering
Description: Tissue integration between bone and orthopedic implant is essential for implant fixation and longevity. An immunological response leads to fibrous encapsulation of metallic implants leading to implant instability and failure. Bioactive ceramics ha...

Title: CHIMERIC ANTIGEN RECEPTOR (CAR) T CELL IMMUNOTHERAPY FOR MUCIN 1 (MUC1)-POSITIVE PANCREATIC DUCTAL ADENOCARCINOMA
Author: Yazdanifar, Mahboubeh
Date Created: 2019
Subjects--Topical: Biology
Description: Chimeric antigen receptor engineered (CAR) T cells have shown remarkable success in the treatment of hematologic cancers. However, this efficacy has yet to translate to treatment in solid tumors. Pancreatic ductal adenocarcinoma (PDA) is a fatal m...

Title: CORTICAL ACTIVITY OF THE SENSORIMOTOR SYSTEM IN PARTICIPANTS WITH CHRONIC ANKLE INSTABILITY
Author: Burcal, Christopher
Date Created: 2017
Subjects--Topical: Biology, Kinesiology, Neurosciences
Description: Patients with chronic ankle instability (CAI) exhibit a wide variety of sensorimotor deficits. These include impairments in feed-forward sensorimotor control (i.e. motor planning) as well as feed-back sensorimotor control, which pertains to refini...

Title: Common Dietary and Environmental Compounds Promote a Leukemic Translocation in Hematopoietic Stem Cells and Differentiated Cells
Author: Vestal, Carol
Date Created: 2016
Subjects--Topical: Molecular biology, Biology, Genetics
Description: Maternal exposure to topoisomerase II (topoII) inhibitors that are biochemically similar to the chemotherapeutic drug etoposide may promote infant acute leukemia. Several studies have shown that common dietary bioflavonoids as well as benzene meta...

Title: Development of injectable bioceramic drug delivery system for solid tumor treatment
Author: Haig, James
Date Created: 2017
Subjects--Topical: Materials science, Engineering, Biomedical engineering
Description: According to the national cancer institute "In 2016, an estimated 1,685,210 new cases of cancer will be diagnosed in the United States and 595,690 people will die from the disease" and "The number of people living beyond a cancer diagnosis reached...

Title: Dry Preservation of Germinal Vesicles: Development of a New Formulation to Preserve DNA Integrity Under Adverse Environmental Conditions
Author: Orozco Cabral, Joseph
Date Created: 2022
Subjects--Topical: Biology, Bioengineering
Description: Advances in the cryopreservation of genetic material has revolutionized human reproductive medicine and animal conservation efforts. Despite many successes, oocytes have been more challenging to cryopreserve than sperm. Their large size makes it d...

Title: EFFECT OF BIOCERAMIC FUNCTIONAL GROUPS ON DRUG BINDING AND RELEASE KINETICS
Author: Trujillo, Christopher
Date Created: 2015
Subjects--Topical: Materials science, Engineering, Biomedical engineering
Description: Bioceramics have been studied extensively as drug delivery systems (DDS). Those studies have aimed to tailor the drug binding and release kinetics to successfully treat infections and other diseases. This research suggests that the drug binding an...

Title: ENGINEERING BIOCERAMIC MICROSTRUCTURE FOR CUSTOMIZED DRUG DELIVERY
Author: Pacheco, Hernando
Date Created: 2013
Subjects--Topical: Engineering, Biomedical engineering
Description: One of the most efficient approaches to treat cancer and infection is to use biomaterials as a drug delivery system (DDS). The goal is for the material to provide a sustained release of therapeutic drug dose locally to target the ill tissue withou...

Title: EXPERIMENTAL EVOLUTION OF ONCOLYTIC VESICULAR STOMATITIS VIRUSES IN CANCER CELLS
Author: Seegers, Sara
Date Created: 2019
Subjects--Topical: Molecular biology, Virology, Biology
Description: Vesicular stomatitis virus (VSV) based oncolytic viruses are promising agents against various cancers. We have shown that pancreatic ductal adenocarcinoma (PDAC) cell lines exhibit great diversity in susceptibility and permissibility to VSV. Here,...

Title: Effects of External Biofeedback on Biomechanics and Ankle Joint Health in Individuals With Chronic Ankle Instability
Author: Torp, Danielle
Date Created: 2021
Subjects--Topical: Kinesiology
Description: Individuals with chronic ankle instability (CAI) often demonstrate abnormal biomechanical patterns which may be associated with the onset of posttraumatic osteoarthritis (PTOA). There is a lack of interventions capable of changing gait impairments...

Title: Examining the Contribution of the DNA Damage Response to Sepsis Survivor Myelosuppression
Author: Huff, Laura
Date Created: 2020
Subjects--Topical: Immunology, Biology, Pathology
Description: A large portion of patients who survive sepsis, a life-threatening hyperinflammatory response to infection resulting in organ dysfunction, experience a higher risk of mortality than non-septic patients. Innate immune cells of sepsis survivors exhi...

Title: FUNCTIONAL NUCLEIC ACID NANOPARTICLES AND THEIR DELIVERY
Author: Ke, Weina
Date Created: 2020
Subjects--Topical: Biochemistry, Cytology
Description: Nucleic acid biopolymers are essential to all living organisms. The chemical makeup of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) consist of sequences of only four monomers. However, they transmit and express genetic information for va...

Title: GLYCOGEN ENHANCEMENT AUGMENTS OVERLOAD-INDUCED PROTEIN SYNTHESIS, GROWTH, AND MYOGENESIS IN AGED SKELETAL MUSCLE
Author: Lawrence, Marcus
Date Created: 2017
Subjects--Topical: Biology, Kinesiology, Physiology
Description: ABSTRACTMARCUS MICHAEL LAWRENCE. Glycogen Enhancement Augments Overload-Induced Protein Synthesis, Growth, and Myogenesis in Aged Skeletal Muscle. (Under the direction of DR. SCOTT E. GORDON)Age-related skeletal muscle (SkM) wasting is associated ...

Title: Hydrogen Sulfide Modulates Hepatic Oxygen Availability and Microcirculation during Sepsis
Author: Norris, Eric
Date Created: 2012
Subjects--Topical: Biology, Physiology
Description: A mismatch between O_{2_{supply and demand leads to the development of tissue hypoxia which contributes to hepatic dysfunction and injury during sepsis. Previously, we reported that hepatic microcirculatory failure is a major contributor to...}}

Title: IDENTIFICATION OF EPITHELIAL OVARIAN TUMOR SPECIFIC APTAMERS THAT BIND AND INTERNALIZE INTO TARGET CELLS
Author: Benedetto, Gregory
Date Created: 2015
Subjects--Topical: Chemistry, Biology
Description: New clinical tools that aid in the early diagnosis of ovarian malignancies will significantly help reduce mortality and improve current long-term survival rates. The objective of the work presented here was to identify ovarian tumor specific singl...

Title: Interaction between hydrogen sulfide and endothelin-1 in hepatic perfusion and mitochondrial dynamics in endotoxemia
Author: Pennington, Samantha
Date Created: 2018
Subjects--Topical: Physiology, Cytology
Description: A mismatch between oxygen supply and metabolic tissue demand leads to the development of hypoxia, which contributes to hepatic dysfunction and liver injury during sepsis. Recent evidence shows that hepatic H2S levels are increased during sepsis an...

Title: MODELING CRASH RISK DUE TO TRAFFIC RULE VIOLATIONS FOR EDUCATION, ENFORCEMENT AND ENGINEERING COUNTERMEASURES
Author: Penmetsa, Praveena
Date Created: 2017
Subjects--Topical: Civil engineering, Transportation
Description: With 1.3 million deaths, motor vehicle crashes contributed to 2.2% of the total deaths in the world during 2012. Traffic rule violations are the major reason for the occurrence of crashes and fatalities world-wide. Education, enforcement and engin...

Title: RED FLUORESCENCE IN BOVINE SERUM ALBUMIN – GOLD COMPLEXES
Author: Dixon, Jacob
Date Created: 2019
Subjects--Topical: Optics, Physics
Description: Bovine serum albumin (BSA)-gold (Au) complexes have been studied in great detail due to their unique red fluorescent (λem = 640 nm) properties, since being initially described by Xie et al. (J. Am. Chem. Soc. 2009, 131, 888-889) as a Au25 nanoclus...

Title: ROLE OF AQUAPORINS DURING HEPATOCELLULAR CARCINOMA INITIATION AND PROGRESSION
Author: Mattocks, Matthew
Date Created: 2010
Subjects--Topical: Molecular biology, Cytology, Oncology
Description: Aquaporins (AQPs) are ubiquitously expressed proteinaceous water channels involved in numerous physiological processes including bile production and apoptosis. Aquaporins 8 and 9 are expressed in hepatocytes, and are down regulated in a rat model ...