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Detection of high prevalence of Plasmodium falciparum histidine-rich protein 2/3 gene deletions in Assosa zone, Ethiopia : implication for malaria diagnosis
Title
Detection of high prevalence of Plasmodium falciparum histidine-rich protein 2/3 gene deletions in Assosa zone, Ethiopia : implication for malaria diagnosis
Author
Janies, Daniel, Blackburn, Kayla, Lopez, Karen, Lo, Eugenia
Date Created
2021
Subjects--Topical
Communicable diseases, Malaria
Description
Background Rapid diagnostic tests (RDTs) targeting histidine rich protein 2(HRP2) are widely used for diagnosis of Plasmodium falciparum infections. Besides PfHRP2, the PfHRP3 antigen contributes to the detection of P. falciparum infections in PfH...
Gene polymorphisms among Plasmodium vivax geographical isolates and the potential as new biomarkers for gametocyte detection
Title
Gene polymorphisms among Plasmodium vivax geographical isolates and the potential as new biomarkers for gametocyte detection
Author
Janies, Daniel, Lo, Eugenia, Ford, Anthony
Date Created
2022
Subjects--Topical
Genomics, Biology
Description
The unique biological features of Plasmodium vivax not only make it difficult to control but also to eliminate. For the transmission of the malaria parasite from infected human to the vector, gametocytes play a major role. The transmission potenti...
Genetic variation of Plasmodium falciparum histidine-rich protein 2 and 3 in Assosa zone, Ethiopia : its impact on the performance of malaria rapid diagnostic tests
Title
Genetic variation of Plasmodium falciparum histidine-rich protein 2 and 3 in Assosa zone, Ethiopia : its impact on the performance of malaria rapid diagnostic tests
Author
Janies, Daniel, Blackburn, Kayla, Lopez, Karen, Lo, Eugenia
Date Created
2021
Subjects--Topical
Communicable diseases, Malaria
Description
Background Rapid diagnostic tests (RDT) are commonly used for the diagnosis of malaria caused by Plasmodium falciparum. However, false negative results of RDT caused by genetic variation of P. falciparum histidine-rich protein 2 and 3 genes (pfhrp...
Implementing landscape genetics in molecular epidemiology to determine drivers of vector‐borne disease : a malaria case study
Title
Implementing landscape genetics in molecular epidemiology to determine drivers of vector‐borne disease : a malaria case study
Author
Lo, Eugenia, Janies, Daneil, Hubbard, Alfred, Afrane, Yaw
Date Created
2023
Subjects--Topical
Malaria, Protozoan diseases
Description
This study employs landscape genetics to investigate the environmental drivers of a deadly vector-borne disease, malaria caused by Plasmodium falciparum, in a more spatially comprehensive manner than any previous work. With 1804 samples from 44 si...
Modeling Plasmodium falciparum diagnostic test sensitivity using machine learning with histidine-rich protein 2 variants
Title
Modeling Plasmodium falciparum diagnostic test sensitivity using machine learning with histidine-rich protein 2 variants
Author
Ford, Colby, Janies, Daniel, Alemayehu, Gezahegn, Lo, Eugenia, Blackburn, Kayla, Lopez, Karen, Dieng, Cheikh Cambel, Golassa, Lemu
Subjects--Topical
Malaria, Plasmodium falciparum
Description
Malaria, predominantly caused by Plasmodium falciparum, poses one of largest and most durable health threats in the world. Previously, simplistic regression-based models have been created to characterize malaria rapid diagnostic test performance, ...
Patch dynamics modeling framework from pathogens' perspective : Unified and standardized approach for complicated epidemic systems
Title
Patch dynamics modeling framework from pathogens' perspective : Unified and standardized approach for complicated epidemic systems
Author
Janies, Daniel, Chen, Shi, Lo, Eugenia, Dulin, Michael
Date Created
2020
Subjects--Topical
Communicable diseases, Biology
Description
Mathematical models are powerful tools to investigate, simulate, and evaluate potential interventions for infectious diseases dynamics. Much effort has focused on the Susceptible-Infected-Recovered (SIR)-type compartment models. These models consi...
Selection and utility of single nucleotide polymorphism markers to reveal fine-scale population structure in human malaria parasite Plasmodium falciparum
Title
Selection and utility of single nucleotide polymorphism markers to reveal fine-scale population structure in human malaria parasite Plasmodium falciparum
Author
Janies, Daniel, Lo, Eugenia, Ford, Anthony
Date Created
2018
Subjects--Topical
Communicable diseases, Malaria
Description
Single nucleotide polymorphisms (SNPs) have been shown to be useful in revealing population structure with continental-and regional-scale samples. In epidemiological study, a careful selection of SNPs to track disease spread in local communities w...