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Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance
Title
Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance
Author
Janies, Daniel, Lo, Eugenia, Kepple, Daniel
Date Created
2019
Subjects--Topical
Communicable diseases, Malaria
Description
Plasmodium vivax invasion of human erythrocytes depends on the Duffy Binding Protein (PvDBP) which interacts with the Duffy antigen. PvDBP copy number has been recently shown to vary between P. vivax isolates in Sub-Saharan Africa. However, the ex...
Gene polymorphisms among Plasmodium vivax geographical isolates and the potential as new biomarkers for gametocyte detection
Title
Gene polymorphisms among Plasmodium vivax geographical isolates and the potential as new biomarkers for gametocyte detection
Author
Janies, Daniel, Lo, Eugenia, Ford, Anthony
Date Created
2022
Subjects--Topical
Genomics, Biology
Description
The unique biological features of Plasmodium vivax not only make it difficult to control but also to eliminate. For the transmission of the malaria parasite from infected human to the vector, gametocytes play a major role. The transmission potenti...
Implementing landscape genetics in molecular epidemiology to determine drivers of vector‐borne disease : a malaria case study
Title
Implementing landscape genetics in molecular epidemiology to determine drivers of vector‐borne disease : a malaria case study
Author
Lo, Eugenia, Janies, Daneil, Hubbard, Alfred, Afrane, Yaw
Date Created
2023
Subjects--Topical
Malaria, Protozoan diseases
Description
This study employs landscape genetics to investigate the environmental drivers of a deadly vector-borne disease, malaria caused by Plasmodium falciparum, in a more spatially comprehensive manner than any previous work. With 1804 samples from 44 si...
Patch dynamics modeling framework from pathogens' perspective : Unified and standardized approach for complicated epidemic systems
Title
Patch dynamics modeling framework from pathogens' perspective : Unified and standardized approach for complicated epidemic systems
Author
Janies, Daniel, Chen, Shi, Lo, Eugenia, Dulin, Michael
Date Created
2020
Subjects--Topical
Communicable diseases, Biology
Description
Mathematical models are powerful tools to investigate, simulate, and evaluate potential interventions for infectious diseases dynamics. Much effort has focused on the Susceptible-Infected-Recovered (SIR)-type compartment models. These models consi...
Selection and utility of single nucleotide polymorphism markers to reveal fine-scale population structure in human malaria parasite Plasmodium falciparum
Title
Selection and utility of single nucleotide polymorphism markers to reveal fine-scale population structure in human malaria parasite Plasmodium falciparum
Author
Janies, Daniel, Lo, Eugenia, Ford, Anthony
Date Created
2018
Subjects--Topical
Communicable diseases, Malaria
Description
Single nucleotide polymorphisms (SNPs) have been shown to be useful in revealing population structure with continental-and regional-scale samples. In epidemiological study, a careful selection of SNPs to track disease spread in local communities w...
Submicroscopic infection and G6PD deficiency in malaria patients
Title
Submicroscopic infection and G6PD deficiency in malaria patients
Author
Witherspoon, Logan, Witherspoon, Logan, Kepple, Daniel, Lo, Eugenia, Abagero, Beka
Date Created
2022, 2022, 2022
Subjects--Topical
Malaria, Public health
Description
Plasmodium vivax malaria is a neglected tropical disease, despite being more geographically widespread than any other form of malaria. Glucose-6-phosphate dehydrogenase (G6PD) is a cytosolic enzyme with a vital role for the integrity and functioni...
Whole genome sequencing of Plasmodium vivax isolates reveals frequent sequence and structural polymorphisms in erythrocyte binding genes
Title
Whole genome sequencing of Plasmodium vivax isolates reveals frequent sequence and structural polymorphisms in erythrocyte binding genes
Author
Janies, Daniel, Lo, Eugenia, Ford, Anthony, Kepple, Daniel
Date Created
2020
Subjects--Topical
Communicable diseases, Malaria
Description
Plasmodium vivax malaria is much less common in Africa than the rest of the world because the parasite relies primarily on the Duffy antigen/chemokine receptor (DARC) to invade human erythrocytes, and the majority of Africans are Duffy negative. R...