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Acquired chemoresistance can lead to increased resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus
Title
Acquired chemoresistance can lead to increased resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus
Author
Grdzelishvili, Valery, Goad, Dakota, Bressy, Christian, Holbrook, Molly
Subjects--Topical
Vesicular stomatitis, Cancer, Viruses
Description
Vesicular stomatitis virus (VSV) is a promising oncolytic virus (OV) against different malignancies, including pancreatic ductal adenocarcinoma (PDAC). Our previous studies have demonstrated that VSV-based OVs are effective against the majority of...
Combining oncolytic virotherapy with p53 tumor suppressor gene therapy
Title
Combining oncolytic virotherapy with p53 tumor suppressor gene therapy
Author
Grdzelishvili, Valery, Bressy, Christian, Hastie, Eric Lawrence
Subjects--Topical
Cancer, Gene therapy
Description
Oncolytic virus (OV) therapy utilizes replication-competent viruses to kill cancer cells, leaving non-malignant cells unharmed. With the first U.S. Food and Drug Administration-approved OV, dozens of clinical trials ongoing, and an abundance of tr...
Novel biomarkers of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus
Title
Novel biomarkers of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus
Author
Grdzelishvili, Valery, Hastie, Eric Lawrence, Cataldi, Marcela, Moerdyk-Schauwecker, Megan J., Felt, Sebastien A., Steuerwald, Nury
Subjects--Topical
Cancer, Viruses
Description
Vesicular stomatitis virus (VSV) based recombinant viruses (such as VSV-ΔM51) are effective oncolytic viruses (OVs) against a majority of pancreatic ductal adenocarcinoma (PDAC) cell lines. However, some PDAC cell lines are highly resistant to VSV...