Search results
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Title
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Cell cycle arrest in G2/M phase enhances replication of interferon-sensitive cytoplasmic RNA viruses via inhibition of antiviral gene expression
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Author
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Grdzelishvili, Valery, Bressy, Christian, Droby, Gaith N., Maldonado, Bryant D., Steuerwald, Nury
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Subjects--Topical
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Cancer, Viruses
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Description
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Vesicular stomatitis virus (VSV) (a rhabdovirus) and its variant VSV-ΔM51 are widely used model systems to study mechanisms of virus-host interactions. Here, we investigated how the cell cycle affects replication of these viruses using an array of...
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Title
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Combining oncolytic virotherapy with p53 tumor suppressor gene therapy
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Author
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Grdzelishvili, Valery, Bressy, Christian, Hastie, Eric Lawrence
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Subjects--Topical
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Cancer, Gene therapy
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Description
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Oncolytic virus (OV) therapy utilizes replication-competent viruses to kill cancer cells, leaving non-malignant cells unharmed. With the first U.S. Food and Drug Administration-approved OV, dozens of clinical trials ongoing, and an abundance of tr...