Search results | J. Murrey Atkins Library

Title: Artificial immune cell, AI-cell, a new tool to predict interferon production by peripheral blood monocytes in response to nucleic acid nanoparticles
Author: Afonin, Kirill A., Chandler, Morgan, Halman, Justin
Date Created: 2022
Subjects--Topical: Nucleic acids, Chemistry
Description: Nucleic acid nanoparticles, or NANPs, rationally designed to communicate with the human immune system, can offer innovative therapeutic strategies to overcome the limitations of traditional nucleic acid therapies. Each set of NANPs is unique in th...

Title: Biomotors, viral assembly, and rna nanobiotechnology: current achievements and future directions
Author: Afonin, Kirill A., Rolband, Lewis
Date Created: 2022
Subjects--Topical: Nucleic acids, Chemistry
Description: The International Society of RNA Nanotechnology and Nanomedicine (ISRNN) serves to further the development of a wide variety of functional nucleic acids and other related nanotechnology platforms. To aid in the dissemination of the most recent adv...

Title: Broccoli fluorets : split aptamers as a user-friendly fluorescent toolkit for dynamic RNA nanotechnology
Author: Afonin, Kirill A., Chandler, Morgan, Halman, Justin
Date Created: 2018
Subjects--Topical: Nucleic acids, Chemistry
Description: RNA aptamers selected to bind fluorophores and activate their fluorescence offer a simple and modular way to visualize native RNAs in cells. Split aptamers which are inactive until the halves are brought within close proximity can become useful fo...

Title: Change in lipofectamine carrier as a tool to fine-tune immunostimulation of nucleic acid nanoparticles
Author: Afonin, Kirill A., Newton, Hannah S., Xu, Jie
Date Created: 2023
Subjects--Topical: Nucleic acids, Chemistry
Description: Nucleic acid nanoparticles (NANPs) require a carrier to allow for their intracellular delivery to immune cells. Cytokine production, specifically type I and III interferons, allows for reliable monitoring of the carrier effect on NANP immunostimul...

Title: Characterization of cationic bolaamphiphile vesicles for sirna delivery into tumors and brain
Author: Afonin, Kirill A., Kim, Taejin, Gupta, Kshitij
Date Created: 2020
Subjects--Topical: Nucleic acids, Chemistry
Description: Small interfering RNAs (siRNAs) are potential therapeutic substances due to their gene silencing capability as exemplified by the recent approval by the US Food and Drug Administration (FDA) of the first siRNA therapeutic agent (patisiran). Howeve...

Title: DNA-templated fluorescent silver nanoclusters inhibit bacterial growth while being non-toxic to mammalian cells
Author: Afonin, Kirill A., Chandler, Morgan, Rolband, Lewis
Date Created: 2021
Subjects--Topical: Nucleic acids, Chemistry
Description: Silver has a long history of antibacterial effectiveness. The combination of atomically precise metal nanoclusters with the field of nucleic acid nanotechnology has given rise to DNA-templated silver nanoclusters (DNA-AgNCs) which can be engineere...

Title: Editorial for the special issue on nucleic acid architectures for therapeutics, diagnostics, devices and materials
Author: Afonin, Kirill A., Halman, Justin
Date Created: 2019
Subjects--Topical: Nucleic acids, Chemistry

Title: Exosome mediated delivery of functional nucleic acid nanoparticles (NANPs)
Author: Afonin, Kirill A., Ke, Weina
Date Created: 2020
Subjects--Topical: Nucleic acids, Chemistry
Description: RNAi-based technologies have shown biomedical potential; however, safe and efficient delivery of RNA remains a barrier for their broader clinical applications. Nucleic acid nanoparticles (NANPs) programmed to self-assemble and organize multiple th...

Title: Expanding structural space for immunomodulatory nucleic acid nanoparticles (NANPs) via spatial arrangement of their therapeutic moieties
Author: Afonin, Kirill A., Chandler, Morgan, Rolband, Lewis
Date Created: 2022
Subjects--Topical: Nucleic acids, Chemistry
Description: Different therapeutic nucleic acids (TNAs) can be unified in a single structure by their elongation with short oligonucleotides designed to self-assemble into nucleic acid nanoparticles (NANPs). With this approach, therapeutic cocktails with preci...

Title: First step towards larger DNA-based assemblies of fluorescent silver nanoclusters: template design and detailed characterization of optical properties
Author: Afonin, Kirill A., Shevchenko, Oleg
Date Created: 2019
Subjects--Topical: Nucleic acids, Chemistry
Description: Besides being a passive carrier of genetic information, DNA can also serve as an architecture template for the synthesis of novel fluorescent nanomaterials that are arranged in a highly organized network of functional entities such as fluorescent ...

Title: Functionally-interdependent shape-switching nanoparticles with controllable properties
Author: Halman, Justin, Khisamutdinov, Emil F., Afonin, Kirill A., Satterwhite, Emily, Roark, Brandon, Chandler, Morgan, Ivanina, Anna, Viard, Mathias, Bindewald, Eckart, Kasprzak, Wojciech K., Panigaj, Martin, Bui, My N., Lu, Jacob S., Miller, Johann, Shapiro, Bruce A., Dobrovolskaia, Marina A.
Subjects--Topical: Nucleic acids, Nanotechnology
Description: We introduce a new concept that utilizes cognate nucleic acid nanoparticles which are fully complementary and functionally-interdependent to each other. In the described approach, the physical interaction between sets of designed nanoparticles ini...

Title: Functionally-interdependent shape-switching nanoparticles with controllable properties
Author: Afonin, Kirill A., Halman, Justin, Chandler, Morgan
Date Created: 2017
Subjects--Topical: Nucleic acids, Chemistry
Description: We introduce a new concept that utilizes cognate nucleic acid nanoparticles which are fully complementary and functionally-interdependent to each other. In the described approach, the physical interaction between sets of designed nanoparticles ini...

Title: Induction of cytokines by nucleic acid nanoparticles (NANPs) depends on the type of delivery carrier
Author: Afonin, Kirill A., Chandler, Morgan, Avila, Yelixza I.
Date Created: 2021
Subjects--Topical: Nucleic acids, Chemistry
Description: Recent insights into the immunostimulatory properties of nucleic acid nanoparticles (NANPs) have demonstrated that variations in the shape, size, and composition lead to distinct patterns in their immunostimulatory properties. While most of these ...

Title: Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells
Author: Afonin, Kirill A., Marriott, Ian, Halman, Justin
Date Created: 2020
Subjects--Topical: Nucleic acids, Chemistry
Description: Background Bacterial meningitis and meningoencephalitis are associated with devastating neuroinflammation. We and others have demonstrated the importance of glial cells in the initiation of immune responses to pathogens invading the central nervou...

Title: Smart-responsive nucleic acid nanoparticles (NANPs) with the potential to modulate immune behavior
Author: Afonin, Kirill A., Chandler, Morgan
Date Created: 2019
Subjects--Topical: Nucleic acids, Chemistry
Description: Nucleic acids are programmable and biocompatible polymers that have beneficial uses in nanotechnology with broad applications in biosensing and therapeutics. In some cases, however, the development of the latter has been impeded by the unknown imm...

Title: Special issue nanotechnology to overcome the world's most critical health issues: liposomes and beyond-a themed issue dedicated to Professor Yechezkel Barenholz
Author: Afonin, Kirill A., Dobrovolskaia, Marina
Date Created: 2023
Subjects--Topical: Nucleic acids, Chemistry

Title: Structure and composition define immunorecognition of nucleic acid nanoparticles
Author: Afonin, Kirill A.
Date Created: 2022, 2022
Subjects--Topical: Immune system, Interferon, Nucleic acids

Title: Structure and composition define immunorecognition of nucleic acid nanoparticles
Author: Afonin, Kirill A.
Date Created: 2022
Subjects--Topical: Immune system, Interferon, Nucleic acids
Description: Nucleic acid nanoparticles (NANPs) have evolved as a new class of therapeutics with the potential to detect and treat diseases. Despite tremendous advancements in NANP development, their immunotoxicity, one of the major impediments in clinical tra...

Title: Structure and composition define immunorecognition of nucleic acid nanoparticles
Author: Afonin, Kirill A.
Date Created: 2022, 2022, 2022
Subjects--Topical: Immune system, Interferon, Nucleic acids

Title: The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Author: Johnson, M. Brittany, Halman, Justin, Marriott, Ian, Afonin, Kirill A., Miller, Daniel K., Cooper, Joseph S., Khisamutdinov, Emil F.
Subjects--Topical: Immunology, Nucleic acids, Nanoparticles
Description: Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...