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Chemoenzymatic Preparation of Probes for in vitro and Cellular Elucidation of Complex Bacteria Polysaccharides
Title
Chemoenzymatic Preparation of Probes for in vitro and Cellular Elucidation of Complex Bacteria Polysaccharides
Author
Reid, Amanda
Date Created
2021
Subjects--Topical
Microbiology, Biochemistry, Analytical chemistry
Description
Bacteria play a major role in our health and wellbeing. The microbe-host interaction is often mediated by sugar polymers at the cell surface. An incredibly diverse amount of glycan variation exists throughout these structures, which makes identifi...
Design and Modulation of Novel Chemical Probes for RNA SHAPE Analysis: Water Soluble Isatoic Anhydrides and Nicotinic Acid Imidazolides
Title
Design and Modulation of Novel Chemical Probes for RNA SHAPE Analysis: Water Soluble Isatoic Anhydrides and Nicotinic Acid Imidazolides
Author
Fessler, Adam
Date Created
2021
Subjects--Topical
Chemistry, Biology
Description
The growing interest in RNA biology, along with an expansion in computational capabilities, throughput, and sensitivity has provided researchers new tools to probe RNA. RNA selective 2′-hydroxy acylation analyzed by primer extension (SHAPE) utiliz...
Dynamic and Conditionally Activated Nucleic Acid Nanoparticles
Title
Dynamic and Conditionally Activated Nucleic Acid Nanoparticles
Author
Chandler, Morgan
Date Created
2021
Subjects--Topical
Nanoscience
Description
Programmed interactions of nucleic acids—including DNA and RNA—orchestrate genetic expression and downstream cellular processes at every level. The structures of nucleic acids rely on their sequences, which include traditional Watson-Crick base pa...