Search results
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Title
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Analysis and Development of Targeting Strategies for Bacterial Sugars
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Author
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Erickson, Katelyn
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Date Created
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2018
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Subjects--Topical
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Chemistry, Biochemistry
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Description
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Bacterial cell surface exopolysaccharides aid in protecting microbes from the defense mechanisms of the host, and differ substantially in structure between species. Exploiting these structural differences would be advantageous to target certain ty...
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Title
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Assessing the Impact of Buffer Salt Choice on the Formation of DNA I-Motifs
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Author
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West, Caroline
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Date Created
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2023
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Subjects--Topical
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Chemistry
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Description
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I-motifs are intercalated cytosine quadruplexes discovered in 1993, but they weren’t shown to exist in the cell nucleus until 2018. While their biological role has yet to be fully elucidated, they have been implicated in regulating expression of s...
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Title
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Bacterial Glycan Immobilization for Interacting Partner Analysis
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Author
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Murray, Alexis
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Date Created
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2023
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Subjects--Topical
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Chemistry
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Description
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Bacterial cell surface glycans mediate pathogenic and symbiotic interactions with hosts and other organisms. The implications of bacterial glycans in human health have made them attractive targets in drug design for antibiotics, antibacterial vacc...
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Title
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Bis(bipyridyl)silicon(IV) Diols as Potential Dual Hydrogen Bond Donors for Catalysis
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Author
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Waters, Crystal
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Date Created
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2016
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Subjects--Topical
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Chemistry
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Description
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Hydrogen bond donors (HBDs) have been explored as potential catalysts for the 1,4-conjugate addition and Diels-Alder reactions. HBD catalysis, which relies on Brønsted acid catalytic sites, is being explored as an oxygen and moisture stable altern...
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Title
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Chemical Tools for Biology
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Author
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Fessler, Adam
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Date Created
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2017
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Subjects--Topical
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Chemistry
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Description
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Reagents for biotinylation that are innately water-soluble and can be tracked by both UV-vis spectroscopy and fluorescence (330nm/420nm) have been developed. These reagents are based on the isatoic anhydride platform, which gives rise to their val...
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Title
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Complex Glycan Synthesis in Bacteria
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Author
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Wallen, Timothy
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Date Created
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2019
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Subjects--Topical
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Chemistry
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Description
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Glycans, which are assembled through a process known as glycosylation, are critical for creating biological structures important for the function and vitality of bacterial cells. In order to study the synthesis of glycans, enzymes and intermediate...
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Title
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Exceptional New Reagents for Bioconjugation
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Author
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Garmon, Corey
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Date Created
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2016
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Subjects--Topical
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Chemistry, Biochemistry
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Description
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At about the turn of this century the term "click" chemistry came into the common vernacular amongst chemists. "Click" is used to describe reactions that are "spring-loaded" and proceed well in a predictable manner, with no offensive byproduct and...
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Title
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FUNCTIONAL NUCLEIC ACID NANOPARTICLES AND THEIR DELIVERY
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Author
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Ke, Weina
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Date Created
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2020
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Subjects--Topical
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Biochemistry, Cytology
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Description
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Nucleic acid biopolymers are essential to all living organisms. The chemical makeup of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) consist of sequences of only four monomers. However, they transmit and express genetic information for va...
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Title
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Green Synthesis of Cellulose Graft Copolymers for Anion Exchange Water Purification
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Author
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Schmal, Stephen
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Date Created
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2022
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Subjects--Topical
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Chemistry
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Description
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This thesis describes the synthesis and characterization of novel cellulose graft copolymers that are used for the purification of drinking water. These nanomaterials function as bottle-brush anion-exchange resins with repeating quaternary ammoniu...
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Title
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HEXACOORDINATE SILICON COMPLEXES FOR ELECTRONIC DEVICES
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Author
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Kochegra, Margaret
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Date Created
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2020
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Subjects--Topical
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Nanoscience
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Description
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Organic electronics such as organic light emitting diodes, organic photovoltaics, organic field effect transistors begin to replace classically used technology. This is due to their tailorability, possibility of smaller and flexible devices, and n...
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Title
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Halogenated Tags for the Investigation of Enzyme Specificity
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Author
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Houde, Hailey
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Date Created
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2023
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Subjects--Topical
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Biochemistry, Chemistry
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Description
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The bacterial enzyme undecaprenyl pyrophosphate synthase (UppS) is present in most prokaryotes and is needed for bacterial survival. UppS produces the essential lipid carrier, bactoprenyl monophosphate (BP). BP is critical for the structural integ...