Search results
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Title
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Analysis and Development of Targeting Strategies for Bacterial Sugars
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Author
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Erickson, Katelyn
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Date Created
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2018
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Subjects--Topical
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Chemistry, Biochemistry
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Description
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Bacterial cell surface exopolysaccharides aid in protecting microbes from the defense mechanisms of the host, and differ substantially in structure between species. Exploiting these structural differences would be advantageous to target certain ty...
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Title
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Assessing the Impact of Buffer Salt Choice on the Formation of DNA I-Motifs
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Author
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West, Caroline
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Date Created
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2023
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Subjects--Topical
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Chemistry
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Description
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I-motifs are intercalated cytosine quadruplexes discovered in 1993, but they weren’t shown to exist in the cell nucleus until 2018. While their biological role has yet to be fully elucidated, they have been implicated in regulating expression of s...
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Title
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Bacterial Glycan Immobilization for Interacting Partner Analysis
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Author
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Murray, Alexis
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Date Created
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2023
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Subjects--Topical
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Chemistry
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Description
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Bacterial cell surface glycans mediate pathogenic and symbiotic interactions with hosts and other organisms. The implications of bacterial glycans in human health have made them attractive targets in drug design for antibiotics, antibacterial vacc...
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Title
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Bis(bipyridyl)silicon(IV) Diols as Potential Dual Hydrogen Bond Donors for Catalysis
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Author
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Waters, Crystal
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Date Created
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2016
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Subjects--Topical
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Chemistry
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Description
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Hydrogen bond donors (HBDs) have been explored as potential catalysts for the 1,4-conjugate addition and Diels-Alder reactions. HBD catalysis, which relies on Brønsted acid catalytic sites, is being explored as an oxygen and moisture stable altern...
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Title
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Chemical Tools for Biology
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Author
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Fessler, Adam
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Date Created
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2017
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Subjects--Topical
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Chemistry
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Description
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Reagents for biotinylation that are innately water-soluble and can be tracked by both UV-vis spectroscopy and fluorescence (330nm/420nm) have been developed. These reagents are based on the isatoic anhydride platform, which gives rise to their val...
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Title
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Complex Glycan Synthesis in Bacteria
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Author
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Wallen, Timothy
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Date Created
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2019
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Subjects--Topical
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Chemistry
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Description
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Glycans, which are assembled through a process known as glycosylation, are critical for creating biological structures important for the function and vitality of bacterial cells. In order to study the synthesis of glycans, enzymes and intermediate...
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Title
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Determining the Rate of Ligand-Induced Charge-Transfer Effects on Quantum Dots
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Author
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Bowman, Cale
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Date Created
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2015
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Subjects--Topical
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Chemistry
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Description
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In this report, charge carrier dynamics and rate of electron transfer is investigated between two bis(thioether)silane (R2BtsMe) ligands and 2.65 nm CdSe core quantum dots (QDs). Isothermal titration calorimetry (ITC) data is used to determine bin...
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Title
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Exceptional New Reagents for Bioconjugation
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Author
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Garmon, Corey
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Date Created
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2016
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Subjects--Topical
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Chemistry, Biochemistry
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Description
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At about the turn of this century the term "click" chemistry came into the common vernacular amongst chemists. "Click" is used to describe reactions that are "spring-loaded" and proceed well in a predictable manner, with no offensive byproduct and...