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HOST FACTORS CONTROLLING VIRUS INFECTION: IMPLICATIONS FOR ANTIVIRALS AND VIROTHERAPY
Title
HOST FACTORS CONTROLLING VIRUS INFECTION: IMPLICATIONS FOR ANTIVIRALS AND VIROTHERAPY
Author
Shah, Nirav
Date Created
2013
Subjects--Topical
Virology, Oncology
Description
Viruses are obligate intracellular parasites rely heavily on host components and pathways for their replication. Studying different cellular factors affecting viral infection can enable us to identify novel drug targets, improve current antiviral ...
THE DEVELOPMENT OF NOVEL THERAPEUTICS IN PANCREATIC AND BREAST CANCERS: POTENTIAL ROLE OF MUC1
Title
THE DEVELOPMENT OF NOVEL THERAPEUTICS IN PANCREATIC AND BREAST CANCERS: POTENTIAL ROLE OF MUC1
Author
Besmer, Dahlia
Date Created
2013
Subjects--Topical
Biology
Description
Pancreatic ductal adenocarcinoma (PDA) is the 4th leading cause of cancer-related deaths in the US, and breast cancer (BC) contributes to ~40,000 deaths annually. The development of novel therapeutic agents for improving patient outcome is of para...
Understanding and overcoming limitations of vesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinoma
Title
Understanding and overcoming limitations of vesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinoma
Author
Hastie, Eric
Date Created
2014
Subjects--Topical
Virology, Biology
Description
Vesicular stomatitis virus (VSV) is a prototypic nonsegmented negative-strand RNA virus. Lack of preexisting immunity against VSV, inherent oncotropism, and genetic malleability make VSV a widely used platform for vaccine, oncolytic, and gene ther...