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Cytosolic DNA sensors and CNS responses to viral pathogens
Title
Cytosolic DNA sensors and CNS responses to viral pathogens
Author
Marriott, Ian, Jeffries, Austin
Subjects--Topical
DNA, Virus diseases
Description
Viral central nervous system (CNS) infections can lead to life threatening encephalitis and long-term neurological deficits in survivors. Resident CNS cell types, such as astrocytes and microglia, are known to produce key inflammatory and antivira...
Cytosolic DNA sensors and glial responses to endogenous DNA
Title
Cytosolic DNA sensors and glial responses to endogenous DNA
Author
Marriott, Ian, Suptela, Alexander J.
Date Created
2023
Subjects--Topical
Genomics, DNA
Description
Genomic instability is a key driving force for the development and progression of many neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of DNA damage responses is a critical step in maintaining genomic integrity ...
Low-dose metformin as a monotherapy does not reduce non-small-cell lung cancer tumor burden in mice
Title
Low-dose metformin as a monotherapy does not reduce non-small-cell lung cancer tumor burden in mice
Author
Marino, Joseph S., Stott Bond, Nicole L., Dréau, Didier, Marriott, Ian, Bennett, Jeanette M., Turner, Michael J., Arthur, Susan
Subjects--Topical
Lungs--Cancer, Musculoskeletal system
Description
Non-small-cell lung cancer (NSCLC) makes up 80–85% of lung cancer diagnoses. Lung cancer patients undergo surgical procedures, chemotherapy, and/or radiation. Chemotherapy and radiation can induce deleterious systemic side effects, particularly wi...
The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Title
The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Author
Johnson, M. Brittany, Halman, Justin, Marriott, Ian, Afonin, Kirill A., Miller, Daniel K., Cooper, Joseph S., Khisamutdinov, Emil F.
Subjects--Topical
Immunology, Nucleic acids, Nanoparticles
Description
Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...