Search results | J. Murrey Atkins Library

Title: APE2 promotes DNA damage response pathway from a single-strand break
Author: Yan, Shan, Lin, Yunfeng, Bai, Liping, Cupello, Steven
Date Created: 2018
Subjects--Topical: Cancer--Research, DNA
Description: As the most common type of DNA damage, DNA single-strand breaks (SSBs) are primarily repaired by the SSB repair mechanism. If not repaired properly or promptly, unrepaired SSBs lead to genome stability and have been implicated in cancer and neurod...

Title: Acquired chemoresistance can lead to increased resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus
Author: Grdzelishvili, Valery, Goad, Dakota, Bressy, Christian, Holbrook, Molly
Subjects--Topical: Vesicular stomatitis, Cancer, Viruses
Description: Vesicular stomatitis virus (VSV) is a promising oncolytic virus (OV) against different malignancies, including pancreatic ductal adenocarcinoma (PDAC). Our previous studies have demonstrated that VSV-based OVs are effective against the majority of...

Title: Cell cycle arrest in G2/M phase enhances replication of interferon-sensitive cytoplasmic RNA viruses via inhibition of antiviral gene expression
Author: Grdzelishvili, Valery, Bressy, Christian, Droby, Gaith N., Maldonado, Bryant D., Steuerwald, Nury
Subjects--Topical: Cancer, Viruses
Description: Vesicular stomatitis virus (VSV) (a rhabdovirus) and its variant VSV-ΔM51 are widely used model systems to study mechanisms of virus-host interactions. Here, we investigated how the cell cycle affects replication of these viruses using an array of...

Title: Cellular bioreactivity of micro- and nano-plastic particles in oysters
Author: Gaspar, Tamara R., Chi, Richard J., Parrow, Matthew W., Ringwood, Amy H.
Subjects--Topical: Plastics, Nanoparticles
Description: The global usage of plastics has increased dramatically over the last several decades. Polystyrene (PS) is the fourth most common plastic material produced annually due to its many versatile applications. Consequently, there has been a coinciding ...

Title: Combining oncolytic virotherapy with p53 tumor suppressor gene therapy
Author: Grdzelishvili, Valery, Bressy, Christian, Hastie, Eric Lawrence
Subjects--Topical: Cancer, Gene therapy
Description: Oncolytic virus (OV) therapy utilizes replication-competent viruses to kill cancer cells, leaving non-malignant cells unharmed. With the first U.S. Food and Drug Administration-approved OV, dozens of clinical trials ongoing, and an abundance of tr...

Title: Creating an online scientific art exhibit formatted for people with a visual impairment
Author: Sorrell, Melanie, Norton, Derek R., McAdams, Jeff, Winterling, Rachael, Dipple, Kathleen
Subjects--Topical: People with visual disabilities, Accessible Web sites for people with disabilities, Academic libraries
Description: An online exhibit accessible by people with a visual impairment was created to accompany a university library’s physical exhibit of microscopic images generated by researchers on campus as “scientific art.” This online exhibit consisted of a Web p...

Title: Current perspectives of telomerase structure and function in eukaryotes with emerging views on telomerase in human parasites
Author: Chakrabarti, Kausik, Dey, Abhishek
Date Created: 2018
Subjects--Topical: Molecular biology, Evolution (Biology)
Description: Replicative capacity of a cell is strongly correlated with telomere length regulation. Aberrant lengthening or reduction in the length of telomeres can lead to health anomalies, such as cancer or premature aging. Telomerase is a master regulator f...

Title: Cytosolic DNA sensors and CNS responses to viral pathogens
Author: Marriott, Ian, Jeffries, Austin
Subjects--Topical: DNA, Virus diseases
Description: Viral central nervous system (CNS) infections can lead to life threatening encephalitis and long-term neurological deficits in survivors. Resident CNS cell types, such as astrocytes and microglia, are known to produce key inflammatory and antivira...

Title: Cytosolic DNA sensors and glial responses to endogenous DNA
Author: Marriott, Ian, Suptela, Alexander J.
Date Created: 2023
Subjects--Topical: Genomics, DNA
Description: Genomic instability is a key driving force for the development and progression of many neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of DNA damage responses is a critical step in maintaining genomic integrity ...

Title: Decoupling behavioral and transcriptional responses to color in an eyeless cnidarian
Author: Reitzel, Adam M., Leach, Whitney
Subjects--Topical: Gene expression, Circadian rhythms
Description: Background Animals have specific molecular, physiological, and behavioral responses to light that are influenced by wavelength and intensity. Predictable environmental changes – predominantly solar and lunar cycles – drive endogenous daily oscilla...

Title: Genetic architecture of early vigor traits in wild soybean
Author: Song, Bao-Hua, Kofsky, Janice, Zhang, Hengyou
Subjects--Topical: Genetics, Genomics, Soybean
Description: A worldwide food shortage has been projected as a result of the current increase in global population and climate change. In order to provide sufficient food to feed more people, we must develop crops that can produce higher yields. Plant early vi...

Title: Genomic alterations and abnormal expression of APE2 in multiple cancers
Author: Yan, Shan, Jensen, Katherine A., Shi, Xinghua
Subjects--Topical: Cancer--Genetic aspects, DNA repair
Description: Although APE2 plays essential roles in base excision repair and ATR-Chk1 DNA damage response (DDR) pathways, it remains unknown how the APE2 gene is altered in the human genome and whether APE2 is differentially expressed in cancer patients. Here,...

Title: In vivo architecture of the telomerase RNA catalytic core in Trypanosoma brucei
Author: Chakrabarti, Kausik, Dey, Abishek, Klotz, Kaitlin, Davis, Justin, Monroy-Eklund, Anais, Saha, Arpita, Li, Bibo, Laederach, Alain
Subjects--Topical: RNA, Nucleoproteins
Description: Telomerase is a unique ribonucleoprotein (RNP) reverse transcriptase that utilizes its cognate RNA molecule as a template for telomere DNA repeat synthesis. Telomerase contains the reverse transcriptase protein, TERT and the template RNA, TR, as i...

Title: Low-dose metformin as a monotherapy does not reduce non-small-cell lung cancer tumor burden in mice
Author: Marino, Joseph S., Stott Bond, Nicole L., Dréau, Didier, Marriott, Ian, Bennett, Jeanette M., Turner, Michael J., Arthur, Susan
Subjects--Topical: Lungs--Cancer, Musculoskeletal system
Description: Non-small-cell lung cancer (NSCLC) makes up 80–85% of lung cancer diagnoses. Lung cancer patients undergo surgical procedures, chemotherapy, and/or radiation. Chemotherapy and radiation can induce deleterious systemic side effects, particularly wi...

Title: Modeling Plasmodium falciparum diagnostic test sensitivity using machine learning with histidine-rich protein 2 variants
Author: Ford, Colby, Janies, Daniel, Alemayehu, Gezahegn, Lo, Eugenia, Blackburn, Kayla, Lopez, Karen, Dieng, Cheikh Cambel, Golassa, Lemu
Subjects--Topical: Malaria, Plasmodium falciparum
Description: Malaria, predominantly caused by Plasmodium falciparum, poses one of largest and most durable health threats in the world. Previously, simplistic regression-based models have been created to characterize malaria rapid diagnostic test performance, ...

Title: New perspectives on SNARE function in the yeast minimal endomembrane system
Author: Chi, Richard J., Grissom, James H., Segarra, Veronica A.
Subjects--Topical: Endocytosis, Cells
Description: Saccharomyces cerevisiae is one of the best model organisms for the study of endocytic membrane trafficking. While studies in mammalian cells have characterized the temporal and morphological features of the endocytic pathway, studies in budding y...

Title: Novel biomarkers of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus
Author: Grdzelishvili, Valery, Hastie, Eric Lawrence, Cataldi, Marcela, Moerdyk-Schauwecker, Megan J., Felt, Sebastien A., Steuerwald, Nury
Subjects--Topical: Cancer, Viruses
Description: Vesicular stomatitis virus (VSV) based recombinant viruses (such as VSV-ΔM51) are effective oncolytic viruses (OVs) against a majority of pancreatic ductal adenocarcinoma (PDAC) cell lines. However, some PDAC cell lines are highly resistant to VSV...

Title: Planning and coordinating an exhibit of photomicrographic art by science faculty and students in an academic library
Author: Sorrell, Melanie, Joseph, Kenya, Norton, Derek R., Reichard, Sharon, McAdams, Jeff
Subjects--Topical: Academic libraries, Exhibitions, Universities and colleges--Faculty
Description: In 2015, the J. Murrey Atkins Library recruited faculty, staff, alumni, and students to submit digital images of photomicrographic art, which were printed and placed on exhibit in the library’s main lobby. Visualizing Science: Microscopic Images f...

Title: Population genomic analyses of the sea urchin Echinometra sp. EZ across an extreme environmental gradient
Author: Ketchum, Remi, Smith, Edward, DeBiasse, Melissa B., Vaughan, Grace, McParland, Dain, Leach, Whitney, Al-Mansoori, Noura, Ryan, Joseph F., Burt, John A., Reitzel, Adam M.
Subjects--Topical: Sea urchins, Extreme environments, Marine biology
Description: Extreme environmental gradients represent excellent study systems to better understand the variables that mediate patterns of genomic variation between populations. They also allow for more accurate predictions of how future environmental change m...

Title: Some like it hot : population-specific adaptations in venom production to abiotic stressors in a widely distributed cnidarian
Author: Reitzel, Adam M., Sachkova, Maria Y., Macrander, Jason, Surm, Joachim M., Aharoni, Reuven, Menard-Harvey, Shelcie S., Klock, Amy, Leach, Whitney, Moran, Yehu
Subjects--Topical: Predation (Biology), Venom
Description: Background In cnidarians, antagonistic interactions with predators and prey are mediated by their venom, whose synthesis may be metabolically expensive. The potentially high cost of venom production has been hypothesized to drive population-specif...