Search results
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Title
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ESSENTIAL DYNAMICS OF PROTEINS USING GEOMETRICAL SIMULATIONS AND SUBSPACE ANALYSIS
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Author
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David, Charles
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Date Created
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2012
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Subjects--Topical
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Physics, Bioinformatics, Biophysics
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Description
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Essential dynamics is the application of principal component analysis to a dynamic trajectory derived from a simulation protocol in order to extract biologically relevant information contained in the high dimensional data. In this work, we apply t...
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Title
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Functional Dynamics in Beta-Lactamase: Insights into Substrate Recognition and Inhibition
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Author
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Avery, Christopher
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Date Created
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2023
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Subjects--Topical
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Bioinformatics, Biophysics, Physics
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Description
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Beta-lactamase proteins are among the most prominent causes of antibiotic resistance. These enzymes confer resistance to beta lactam antibiotics, which are commonly used to treat bacterial infections. In recent years, novel beta-lactamase have eme...
