Faithful repair of chromosomal double-strand breaks (DSBs) is crucial to genome stability and normal cell survival and proliferation. During normal metabolic processes and especially following exposure to DNA damaging agents including irradiation,...
Infant acute leukemias account for ~30% of all malignancy seen in childhood across the Western world. They are aggressive and characterized by rapid onset shortly after birth. The majority of these have rearrangements involving the MLL (mixed line...
