Search results
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Title
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ANCESTRAL COMPLEXITY AND LINEAGE SPECIFIC EXPANSIONS OF THE ANIMAL BZIP INTERACTOME
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Author
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Kane, Eric
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Date Created
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2017
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Subjects--Topical
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Bioinformatics, Evolutionary developmental biology
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Description
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Protein-protein interactions are central to the regulation and function of transcription factors in time- and cell-specific regulation of the genome. Increases in interactome complexity may serve as a mechanistic driver for evolutionary novelty. T...
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Title
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DO DYNAMIC ALLOSTERIC EFFECTS OCCUR IN IGG4 ANTIBODIES?
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Author
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Baker, Lonnie
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Date Created
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2020
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Subjects--Topical
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Bioinformatics, Biophysics
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Description
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Antibodies are large, multi-chain proteins which play a critical roll in the func-tioning of vertebrate immune systems. Immune effector cells which are responsiblefor the destruction of foreign antigens do not randomly target molecules but rely on...
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Title
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THERMODYNAMIC AND MECHANICAL EFFECTS OF DISULFIDE BONDS IN CXCL7 CHEMOKINE
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Author
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Singer, Christopher
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Date Created
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2015
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Subjects--Topical
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Physics, Bioinformatics, Biophysics
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Description
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Chemokines are a family of signaling proteins mainly responsible for the chemotaxis of leukocytes, where their biological activity is modulated by their oligomerization state. Here, the dynamics and thermodynamic stability are characterized in mon...
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Title
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The in-vivo Evolution of Burkholderia multivorans in a Cystic Fibrosis patient
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Author
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Harrison, Sarah
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Date Created
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2021
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Subjects--Topical
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Biology, Microbiology, Bioinformatics
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Description
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ABSTRACT Burkholderia multivorans is an opportunistic pathogen that poses a health risk to patients with cystic fibrosis (CF). The use of broad-range antibiotics to combat chronic bacterial lung infections has led to the evolution of antibiotic-re...