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Broccoli fluorets : split aptamers as a user-friendly fluorescent toolkit for dynamic RNA nanotechnology
Title
Broccoli fluorets : split aptamers as a user-friendly fluorescent toolkit for dynamic RNA nanotechnology
Author
Afonin, Kirill A., Chandler, Morgan, Halman, Justin
Date Created
2018
Subjects--Topical
Nucleic acids, Chemistry
Description
RNA aptamers selected to bind fluorophores and activate their fluorescence offer a simple and modular way to visualize native RNAs in cells. Split aptamers which are inactive until the halves are brought within close proximity can become useful fo...
Change in lipofectamine carrier as a tool to fine-tune immunostimulation of nucleic acid nanoparticles
Title
Change in lipofectamine carrier as a tool to fine-tune immunostimulation of nucleic acid nanoparticles
Author
Afonin, Kirill A., Newton, Hannah S., Xu, Jie
Date Created
2023
Subjects--Topical
Nucleic acids, Chemistry
Description
Nucleic acid nanoparticles (NANPs) require a carrier to allow for their intracellular delivery to immune cells. Cytokine production, specifically type I and III interferons, allows for reliable monitoring of the carrier effect on NANP immunostimul...
DNA-templated fluorescent silver nanoclusters inhibit bacterial growth while being non-toxic to mammalian cells
Title
DNA-templated fluorescent silver nanoclusters inhibit bacterial growth while being non-toxic to mammalian cells
Author
Afonin, Kirill A., Chandler, Morgan, Rolband, Lewis
Date Created
2021
Subjects--Topical
Nucleic acids, Chemistry
Description
Silver has a long history of antibacterial effectiveness. The combination of atomically precise metal nanoclusters with the field of nucleic acid nanotechnology has given rise to DNA-templated silver nanoclusters (DNA-AgNCs) which can be engineere...
Induction of cytokines by nucleic acid nanoparticles (NANPs) depends on the type of delivery carrier
Title
Induction of cytokines by nucleic acid nanoparticles (NANPs) depends on the type of delivery carrier
Author
Afonin, Kirill A., Chandler, Morgan, Avila, Yelixza I.
Date Created
2021
Subjects--Topical
Nucleic acids, Chemistry
Description
Recent insights into the immunostimulatory properties of nucleic acid nanoparticles (NANPs) have demonstrated that variations in the shape, size, and composition lead to distinct patterns in their immunostimulatory properties. While most of these ...
Special issue nanotechnology to overcome the world's most critical health issues: liposomes and beyond-a themed issue dedicated to Professor Yechezkel Barenholz
Title
Special issue nanotechnology to overcome the world's most critical health issues: liposomes and beyond-a themed issue dedicated to Professor Yechezkel Barenholz
Author
Afonin, Kirill A., Dobrovolskaia, Marina
Date Created
2023
Subjects--Topical
Nucleic acids, Chemistry
The recognition of and reactions to nucleic acid nanoparticles by human immune cells
Title
The recognition of and reactions to nucleic acid nanoparticles by human immune cells
Author
Afonin, Kirill A., Bila, Dominika, Panigaj, Martin
Date Created
2021
Subjects--Topical
Nucleic acids, Chemistry
Description
The relatively straightforward methods of designing and assembling various functional nucleic acids into nanoparticles offer advantages for applications in diverse diagnostic and therapeutic approaches. However, due to the novelty of this approach...
Toll-like receptor-mediated recognition of nucleic acid nanoparticles (NANPs) in human primary blood cells
Title
Toll-like receptor-mediated recognition of nucleic acid nanoparticles (NANPs) in human primary blood cells
Author
Afonin, Kirill A., Truong, Nguyen, Halman, Justin
Date Created
2019
Subjects--Topical
Nucleic acids, Chemistry
Description
Infusion reactions (IRs) create a translational hurdle for many novel therapeutics, including those utilizing nanotechnology. Nucleic acid nanoparticles (NANPs) are a novel class of therapeutics prepared by rational design of relatively short olig...