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EXPERIMENTAL EVOLUTION OF ONCOLYTIC VESICULAR STOMATITIS VIRUSES IN CANCER CELLS
Title
EXPERIMENTAL EVOLUTION OF ONCOLYTIC VESICULAR STOMATITIS VIRUSES IN CANCER CELLS
Author
Seegers, Sara
Date Created
2019
Subjects--Topical
Molecular biology, Virology, Biology
Description
Vesicular stomatitis virus (VSV) based oncolytic viruses are promising agents against various cancers. We have shown that pancreatic ductal adenocarcinoma (PDAC) cell lines exhibit great diversity in susceptibility and permissibility to VSV. Here,...
REGULATION OF APE1 BY NEIL3 ZINC FINGER-GRF REPEAT ON SINGLE-STRANDED DNA
Title
REGULATION OF APE1 BY NEIL3 ZINC FINGER-GRF REPEAT ON SINGLE-STRANDED DNA
Author
Ha, Anh
Date Created
2020
Subjects--Topical
Molecular biology, Cytology
Description
Base excision repair (BER) is a critical pathway in repairing single base lesions caused by oxidation, deamination, and alkylation. NEIL3 is a DNA glycosylase which functions in initiating BER pathway by recognizing and removing damaged bases. Alt...
Dissecting functional differences in Hsp70 isoforms in nematostella vectensis
Title
Dissecting functional differences in Hsp70 isoforms in nematostella vectensis
Author
Waller, Shawn
Date Created
2018
Subjects--Topical
Molecular biology
Description
Heat shock protein 70s (Hsp70s) are a highly conserved class of molecular chaperones that are involved in cellular processes in all organisms such as stress response, homeostatic maintenance, and cell cycle progression. The organism Nematostella v...
Loss of Skeletal Muscle PKC Theta Protects Against The Pathogenesis of Insulin Resistance
Title
Loss of Skeletal Muscle PKC Theta Protects Against The Pathogenesis of Insulin Resistance
Author
Peck, Bailey
Date Created
2016
Subjects--Topical
Molecular biology, Medical sciences
Description
Skeletal muscle is a primary regulator of glucose homeostasis, accounting for the majority of post-prandial glucose disposal. However states of skeletal muscle insulin-resistance result in severely attenuated glucose uptake and consequently hyperg...
THE ROLE OF TRANSLESION SYNTHESIS POLYMERASES REV1 AND POL η IN DNA DAMAGE RESPONSE
Title
THE ROLE OF TRANSLESION SYNTHESIS POLYMERASES REV1 AND POL η IN DNA DAMAGE RESPONSE
Author
McLeod, Melissa
Date Created
2016
Subjects--Topical
Molecular biology, Biology, Cytology
Description
Our cells endure continuous challenges from byproducts of endogenous metabolic processes as well as outside sources such as UV light and environmental polltants. The DNA Damage Response (DDR) helps organisms cope with damage and coordinate an appr...
Inflammasome-driven IL-1ß and IL-18 cytokine signaling between macrophages and cancer cells within the breast tumor microenvironment
Title
Inflammasome-driven IL-1ß and IL-18 cytokine signaling between macrophages and cancer cells within the breast tumor microenvironment
Author
Suryaprakash, Deepika
Date Created
2018
Subjects--Topical
Molecular biology, Oncology
Description
Breast cancer especially triple-negative breast cancer remains deadly, despite detection, monitoring and therapeutic advances. Indeed, aggressive breast cancers metastasize to tissues including the brain, bones, and lungs. Metastasis is favored by...
Characterizing a New Regulator of the ATR Signaling Pathway
Title
Characterizing a New Regulator of the ATR Signaling Pathway
Author
Biller, Megan
Date Created
2022
Subjects--Topical
Molecular biology, Biology
Description
Cellular responses to DNA damage and replication stress are coordinated by an intricate network of repair pathways known as the DNA damage response (DDR). Central to the DDR is the essential kinase ataxia telangiectasia mutated and Rad3-related (A...
The Potential for Genistein, a Topoisomerase II Inhibitor, to Induce Inter-Chromosomal Homologous Recombination.
Title
The Potential for Genistein, a Topoisomerase II Inhibitor, to Induce Inter-Chromosomal Homologous Recombination.
Author
French, Caroline
Date Created
2023
Subjects--Topical
Molecular biology
Description
Maintenance of genome integrity is important for preventing mutagenic events and preserving overall cell functionality. DNA damaging agents induce DNA double strand breaks (DSBs) that are repaired through repair pathways non-homologous end-joining...