Search results | J. Murrey Atkins Library

Title: EXPERIMENTAL EVOLUTION OF ONCOLYTIC VESICULAR STOMATITIS VIRUSES IN CANCER CELLS
Author: Seegers, Sara
Date Created: 2019
Subjects--Topical: Molecular biology, Virology, Biology
Description: Vesicular stomatitis virus (VSV) based oncolytic viruses are promising agents against various cancers. We have shown that pancreatic ductal adenocarcinoma (PDAC) cell lines exhibit great diversity in susceptibility and permissibility to VSV. Here,...

Title: ASSESSING COMPARATIVE FUNCTIONS FOR THE BZIP TRANSCRIPTION FACTOR NFE2 IN NEMATOSTELLA VECTENSIS
Author: Clegg, Devin
Date Created: 2020
Subjects--Topical: Biology
Description: The bZIP gene superfamily is a family of transcription factors that have gone through multiple duplication events within bilaterians, specifically in vertebrates. This has led to multiple paralogs in each bZIP family while early diverging phyla ha...

Title: The induction of type-I interferon responses in primary osteoblasts following staphylococcus aureus infection
Author: Furr, Kelli
Date Created: 2022
Subjects--Topical: Biology
Description: Osteomyelitis is a serious bacterial infection of bone that is associated with progressive inflammatory tissue damage. This condition commonly affects the long bones of children along with the vertebrae and pelvis of adults. Staphylococcus aureus,...

Title: Assessing the impact of temperature on population-specific gene expression of a model estuarine cnidarian, Nematostella vectensis
Author: Klock, Amy
Date Created: 2020
Subjects--Topical: Biology
Description: Temperature is a critical environmental factor that affects all living organisms. Climate change is resulting in rising global temperatures with marine environments being especially vulnerable. My study aimed to elucidate the temperature-dependent...

Title: ELUCIDATING THE MOLECULAR BASIS OF INHIBITION OF ENZYMES ESSENTIAL FOR BATERIALVIRULENCE: THE ACTIVITY OF THREE GLYCOSYLTRANSFERASES AND A POTENTIAL DRUG TARGET, UNDECAPRENYL PYROPHOSPHATE SYNTHASE
Author: Okwei, Elleansar
Date Created: 2016
Subjects--Topical: Chemistry, Biology, Biochemistry
Description: The fight against bacterial infection is one of the most important branches of modern medicine. Due to the emergence of strains of antibiotic-resistant bacteria, researchers have been presented with complex challenges in an effort to combat these ...

Title: Dry Preservation of Germinal Vesicles: Development of a New Formulation to Preserve DNA Integrity Under Adverse Environmental Conditions
Author: Orozco Cabral, Joseph
Date Created: 2022
Subjects--Topical: Biology, Bioengineering
Description: Advances in the cryopreservation of genetic material has revolutionized human reproductive medicine and animal conservation efforts. Despite many successes, oocytes have been more challenging to cryopreserve than sperm. Their large size makes it d...

Title: MACROPHAGES EXPRESSING NEUROPILIN-1 AND BREAST TUMOR PROGRESSION
Author: Helms, Rachel
Date Created: 2015
Subjects--Topical: Biology
Description: Human breast carcinoma is the most commonly diagnosed cancer in women in the United States with patient mortality primarily resulting from metastasis of breast cancer cells to distant organs. Immune cells, including macrophages, are involved in ca...

Title: Examining the Contribution of the DNA Damage Response to Sepsis Survivor Myelosuppression
Author: Huff, Laura
Date Created: 2020
Subjects--Topical: Immunology, Biology, Pathology
Description: A large portion of patients who survive sepsis, a life-threatening hyperinflammatory response to infection resulting in organ dysfunction, experience a higher risk of mortality than non-septic patients. Innate immune cells of sepsis survivors exhi...

Title: Exploring the Immune System using Hybrid Cube Nanoparticles
Author: McMillan, Jessica
Date Created: 2021
Subjects--Topical: Biochemistry, Nanotechnology, Biology
Description: Nano-sized cubes made from nucleic acid material (NANPs) are ideal scaffolds for therapeutic nucleic acids (TNAs). Both utilize sequence specificity through base-pairing, providing controlled strand interaction, stability, and targeted targeting d...

Title: Fibroblast-driven Fibrosis and Inflammation in Breast Cancer Progression
Author: Samuels, Courtney
Date Created: 2022
Subjects--Topical: Biology
Description: Breast cancer progression is promoted by both local inflammation and fibrosis. Indeed,accumulation of fibrous collagen is an independent prognosis marker of breast cancer. However, the mechanisms underlying the interplay between fibroblasts, infla...

Title: A STRUCTURAL AND FUNCTIONAL ANALYSIS OF NEMATOSTELLA VECTENSIS MAJOR INTRINSIC PROTEINS
Author: Taylor, Jonathon
Date Created: 2020
Subjects--Topical: Biology, Cytology, Evolutionary developmental biology
Description: There is currently a major gap in understanding the physiological processes of tissue grade animals from early diverging phyla, particularly within the context of the molecular mechanisms in response to osmotic variation. A key protein family esse...

Title: CELLULAR BIOMARKER RESPONSES OF THE ASIAN CLAM, CORBICULA FLUMINEA, NEAR A COAL ASH POND
Author: Thomason, Travis
Date Created: 2018
Subjects--Topical: Biology
Description: The storage of coal combustion residuals (CCR) in aquatic surface impoundments has been a common practice across the United States for decades. Typically these aquatic surface impoundments are designed to allow the upper portion of the ash-basin w...

Title: Oral Microbiome Signature for Hematological Cancer
Author: Langdon, Holden
Date Created: 2020
Subjects--Topical: Biology
Description: BackgroundThe endogenous microbiome of healthy individuals in the oral cavity is diverse, representing over 700 different bacterial species. Some of these species may become opportunistic if certain elements in the microenvironment and host-respon...

Title: The Moon Jellyfish (Aurelia aurita): A Prospective Pelagic and Estuarine Bioindicator
Author: Lowder, Matthew
Date Created: 2016
Subjects--Topical: Biology, Environmental sciences, Toxicology
Description: Due in part to the complexity of scyphozoan life histories, slight changes in environmental factors can have an effect on fecundity, growth & development and population fluctuations. Anthropogenic activities have been suggested as a major cause of...

Title: Understanding Salt Adaptation in Sand Beans (Strophostyles helvola)
Author: Zuelsdorf, Christine
Date Created: 2018
Subjects--Topical: Biology
Description: Soil salinity is one of the major environmental factors causing crop yield loss worldwide. Different plants develop diverse salinity tolerance mechanisms to manage such a detrimental abiotic stress. The sand bean (Strophostyles helvola), a wild re...

Title: The Relationship of Reproductive Hormones and Host Susceptibility to the Opportunistic Pathogen, Vibrio vulnificus
Author: McKee, Leslie
Date Created: 2015
Subjects--Topical: Biology, Microbiology, Endocrinology
Description: It is commonly found that males show a higher susceptibility to infectious diseases. While the underlying mechanism for this sex difference is not fully understood, one significant contributing attribute is the presence of specific sex hormones- e...

Title: Screening of FDA-Approved Drug Library for Combinatorial Treatment of Pancreatic Ductal Adenocarcinoma Cells with Oncolytic Vesicular Stomatitis Virus
Author: Holbrook, Molly
Date Created: 2021
Subjects--Topical: Biology
Description: Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with poor prognosis and a dismal survival rate, expected to become the second leading cause of cancer-related deaths in the United States. Oncolytic virus (OV) is an anticancer ap...

Title: THE ROLE OF TRANSLESION SYNTHESIS POLYMERASES REV1 AND POL η IN DNA DAMAGE RESPONSE
Author: McLeod, Melissa
Date Created: 2016
Subjects--Topical: Molecular biology, Biology, Cytology
Description: Our cells endure continuous challenges from byproducts of endogenous metabolic processes as well as outside sources such as UV light and environmental polltants. The DNA Damage Response (DDR) helps organisms cope with damage and coordinate an appr...

Title: Study of Enzymes Required for the Synthesis of the Enterobacterial Common Antigen in Vitro
Author: Oliverio, Cassidy
Date Created: 2021
Subjects--Topical: Biology
Description: In recent years, the Center for Disease Control (CDC) has highlighted many bacteria as being either serious or urgent threats in terms of antibiotic resistance such as Salmonella enterica, Klebsiella, and Shigella. These bacteria are all members o...

Title: THE EFFECTS OF ISOMETRIC EXERCISE ON IMMEDIATE POST-ISOMETRIC EXERCISE GLUCOSE TOLERANCE
Author: Green, Spencer
Date Created: 2018
Subjects--Topical: Biology, Kinesiology, Medical sciences
Description: Dynamic exercise has been shown to improve glucose tolerance. However, it’s unclear if isometric exercise produces a similar benefit. The purpose of this study was to observe if an isometric exercise session acutely improved glucose tolerance in 1...