Search results
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Title
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APE2 promotes DNA damage response pathway from a single-strand break
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Author
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Yan, Shan, Lin, Yunfeng, Bai, Liping, Cupello, Steven
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Date Created
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2018
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Subjects--Topical
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Cancer--Research, DNA
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Description
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As the most common type of DNA damage, DNA single-strand breaks (SSBs) are primarily repaired by the SSB repair mechanism. If not repaired properly or promptly, unrepaired SSBs lead to genome stability and have been implicated in cancer and neurod...
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Title
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Cytosolic DNA sensors and CNS responses to viral pathogens
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Author
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Marriott, Ian, Jeffries, Austin
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Subjects--Topical
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DNA, Virus diseases
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Description
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Viral central nervous system (CNS) infections can lead to life threatening encephalitis and long-term neurological deficits in survivors. Resident CNS cell types, such as astrocytes and microglia, are known to produce key inflammatory and antivira...
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Title
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Cytosolic DNA sensors and glial responses to endogenous DNA
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Author
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Marriott, Ian, Suptela, Alexander J.
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Date Created
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2023
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Subjects--Topical
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Genomics, DNA
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Description
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Genomic instability is a key driving force for the development and progression of many neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of DNA damage responses is a critical step in maintaining genomic integrity ...
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Title
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Modeling of ssDNA binding protein structures
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Author
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Jariwala, Maanav, Guo, Jun-tao
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Date Created
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2022
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Subjects--Topical
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DNA, Protein binding
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Description
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Single-stranded DNA (ssDNA) binding proteins are crucial for biological processes including replication, transcription, and genomic integrity. We can better comprehend the function of the proteins and their interactions with ssDNA with structures ...