Search results | J. Murrey Atkins Library

Title: APE2 promotes DNA damage response pathway from a single-strand break
Author: Yan, Shan, Lin, Yunfeng, Bai, Liping, Cupello, Steven
Date Created: 2018
Subjects--Topical: Cancer--Research, DNA
Description: As the most common type of DNA damage, DNA single-strand breaks (SSBs) are primarily repaired by the SSB repair mechanism. If not repaired properly or promptly, unrepaired SSBs lead to genome stability and have been implicated in cancer and neurod...

Title: ComparePD : improving protein–DNA complex model comparison with hydrogen bond energy-based metrics
Author: Guo, Jun-tao, Malik, Fareeha Kanwal
Date Created: 2023
Subjects--Topical: DNA, Nucleic acids
Description: Computational modeling of protein–DNA complex structures has important implications in biomedical applications such as structure-based, computer aided drug design. A key step in developing methods for accurate modeling of protein–DNA complexes is ...

Title: Cytosolic DNA sensors and CNS responses to viral pathogens
Author: Marriott, Ian, Jeffries, Austin
Subjects--Topical: DNA, Virus diseases
Description: Viral central nervous system (CNS) infections can lead to life threatening encephalitis and long-term neurological deficits in survivors. Resident CNS cell types, such as astrocytes and microglia, are known to produce key inflammatory and antivira...

Title: Cytosolic DNA sensors and glial responses to endogenous DNA
Author: Marriott, Ian, Suptela, Alexander J.
Date Created: 2023
Subjects--Topical: Genomics, DNA
Description: Genomic instability is a key driving force for the development and progression of many neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of DNA damage responses is a critical step in maintaining genomic integrity ...

Title: Modeling of ssDNA binding protein structures
Author: Jariwala, Maanav, Guo, Jun-tao
Date Created: 2022
Subjects--Topical: DNA, Protein binding
Description: Single-stranded DNA (ssDNA) binding proteins are crucial for biological processes including replication, transcription, and genomic integrity. We can better comprehend the function of the proteins and their interactions with ssDNA with structures ...

Title: Z-DNA binding protein 1 mediates necroptotic and apoptotic cell death pathways in murine astrocytes following herpes simplex virus-1 infection
Author: Marriott, Ian, Jeffries, Austin M., Suptela, Alexander J.
Date Created: 2022
Subjects--Topical: Herpes simplex virus, DNA
Description: The mechanisms by which glia respond to viral central nervous system (CNS) pathogens are now becoming apparent with the demonstration that microglia and astrocytes express an array of pattern recognition receptors that include intracellular RNA an...